Press Release: Vetmeduni Vienna

Vetmeduni Vienna, January 25th 2021: Extension of “Monarchies and Hierarchies in Shaping Chromatin Landscapes” Special Research Programme funded by Austrian Science Fund FWF https://www.vetmeduni.ac.at/en/infoservice/press-releases/presseinformationen-2021/extension-of-monarchies-and-hierarchies-in-shaping-chromatin-landscapes-special-research-programme/   Second funding period (2021-2025) for SFB F61 approved in the FWF Board meeting from 23rd to 25th of November 2020.   Summary of the Research Program The STAT proteins are […]

Press Release: Joined seminar series of FWF Vienna DocFund with SFBs

In Q2 2021 a common seminar series of the FWF-funded Vienna Life Science Region research consortia of DocFund TissueHome (speakers Karl Kuchler & Birgit Strobl; https://tissuehome.meduniwien.ac.at), SFB HIT: HADCs – Immunomolulation – T cells (speaker Willfried Ellmeier; https://www-new.meduniwien.ac.at/HIT/) and the SFB JAK-STAT & Chromatin Landscapes (speakers Mathias Müller & Thomas Decker) will start. Please look […]

Press Release: Joined forces of FWF SFB with DFG TRR

Joined forces of FWF SFB with DFG TRR: the Viennese JAK-STAT consortium and the DFG funded Transregio (TRR) research consortium ‘Determinants and Dynamics of Elimination versus Persistence of Hepatitis Virus Infection’ (TRR179) coordinated by Ralf Bartenschlager (http://www.trr179.de/en/) initiated a collaboration with future researcher exchanges and lab visitations. Press Release

Thomas Krausgruber receives the Karl Landsteiner Award

Thomas Krausgruber receives the Karl Landsteiner Award for Immunological Basic Research of the Austrian Society for Allergology and Immunology (ÖGAI, www.oegai.org) handed over at the Virtual Congress Day December 4th 2020. The Award Committee of the ÖGAI supported by international reviewers selected Thomas Krausgruber from Christoph Bock’s lab for his work and widely recognized publication […]

Press Release: Vetmeduni Vienna

Vetmeduni Vienna, January 25th 2021: Extension of “Monarchies and Hierarchies in Shaping Chromatin Landscapes” Special Research Programme funded by Austrian Science Fund FWF https://www.vetmeduni.ac.at/en/infoservice/press-releases/presseinformationen-2021/extension-of-monarchies-and-hierarchies-in-shaping-chromatin-landscapes-special-research-programme/   Second funding period (2021-2025) for SFB F61 approved in the FWF Board meeting from 23rd to 25th of November 2020. Summary of the Research Program The STAT proteins are transcription […]

Tobias Suske receives Milstein Abstract Award for Cytokines 2020 Virtual Meeting

The Award Committee of the International Cytokine and Interferon Society (ICIS) selected the SFB PhD student Tobias Suske from Richard Moriggl’s lab for a Milstein Abstract Award in the amount of $500 in recognition of his presentation at Cytokines 2020 Virtual Meeting held at 1 – 4 November (https://seattle.cytokinesociety.org). The talk entitled “The Activating STAT5BN642H Driver […]

Molecular Pathology and TYK2 Activity During Endotoxin-induced Hyperinflammation

The SFB members Birgit Strobl, Mathias Müller and Richard Moriggl show in complex mouse models and human cells the pivotal role of TYK2 in the development of severe organ damage during endotoxemia. Mechanistically the TYK2-dependent pathology was driven by murine caspase-11 (CASP11) or the human homolog CASP5 activity and the subsequent release of IL-1ß and IL-18. […]

Distinct Functions of STAT1 Isoforms in NK Cell Maturation and Cytotoxicity

Using sophisticated genetically engineered mouse models the SFB members Birgit Strobl, Mathias Müller and Veronika Sexl further dissect the NK cell-intrinsic and -extrinsic requirements for STAT1a versus STAT1b in NK cell biology and tumor surveillance. Published in Frontiers in Immunology Kartin Meissl, Natalija Simonović, Lena Amenitsch, Agnieszka Witalisz-Siepracka, Klara Klein, Caroline Lassnig, Ana Puga, Claus […]

Therapeutic targeting of STAT3 by monobodies

Therapeutic targeting of STAT3 by monobodies An international consortium headed by the Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences ETH Lausanne collaborated with Veronika Sexl group members and developed the first monobodies targeted against STAT3. Monobodies are synthetic binding proteins engineered to selectively bind intracellular proteins – also those lacking an […]

Combining the predictive power of deep learning with the interpretability of cell signaling networks

Nikolaus Fortelny and Christoph Bock of CeMM showed the usefulness of knowledge-primed neural networks (KPNNs) for the interpretation of single-cell RNA-seq data. They expect that the use of deep learning on biological networks will also be relevant in other areas of biomedicine analysing big data sets, including metabolomics, proteomics and cellular or cognitive networks. Published […]