SFB granted in 2016 – endeavour of the integrative data analysis going far beyond the current state-of-the-art for JAK-STAT signalling analyses published in 2024 CEMM | VETMEDUNI | MPL DOI: 10.1038/s41590-024-01804-1 The integrative efforts of all SFB members have produced the following deliverables and often surprising insights into JAK-STAT biology: Transcriptome and epigenome variability in homeostasis […]
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive immature T cell cancer. A research team led by Prof. Richard Moriggl at the University of Veterinary Medicine Vienna has studied the most frequent and clinically challenging STAT5BN642H driver in T cell development and immature T cell cancer onset in genetically modified mice. Supported by SFB […]
The SFB Jak-Stat subproject leader Richard Moriggl took the full professorship Biochemistry and Metabolism Research at the Department of Biosciences & Medical Biology of the Paris Lodron University Salzburg in March 2024. The SFB member congratulate Richard to this career step. Richard will remain an associate member of the SFB. Mathias Müller – the coordinator […]
Bacillus Calmette-Guérin (BCG) is one of the world’s oldest and most widely used vaccines. It was developed in the early 20th century to provide protection from tuberculosis. Surprisingly, this vaccine protects not only against tuberculosis but also reduces the risk for various other infections, through a mechanism called trained immunity. A new study led by SFB […]
Myint Aung (group Heidi Neubauer) and Jonatan Kendler (group Richard Moriggl) were each awarded one of the coveted DOC scholarships of the Austrian Academy of Sciences (ÖAW, https://stipendien.oeaw.ac.at/en/fellowships/doc). The scholarships are awarded to outstanding young scientists in a highly competitive selection process. Myint will use preclinical mouse modelst o investigate the oncogenic STAT5B-driven disease mechanisms […]
On 16 May 2023 Sylvia Knapp, Professor of Infection Biology at the Medical University of Vienna and PI of SFB F61, was awarded the Prize of the City of Vienna in the category Medical Sciences. The awards for outstanding achievements in culture and science were presented by the City Councillor for Culture and Science, Veronica […]
The SFB members Anna Orlova and Richard Moriggl are co-founders of the pharmaceutical start-up RIANA Therapeutics spun out of Vetmeduni Vienna in February 2023. RIANA Therapeutics focuses on developing novel anti-cancer treatments with hope to improve life of cancer patients. For further information see https://www.vetmeduni.ac.at/en/universitaet/infoservice/presseinformationen/presseinformationen-2023/riana-viennese-start-up-develops-novel-precise-anti-cancer-drugs
The SFB Jak-Stat subproject leader Veronika Sexl took the lead of the University of Innsbruck (https://www.uibk.ac.at/en/) in March 2023. Veronika was appointed head of the rectorate in an international selection process for a period of four years. The SFB members congratulate Veronika to this highly responsible and prestigious position. We will miss Veronika’s scientific excellence […]
Interferons (IFNs) activate cell-intrinsic defence mechanisms to fight infections. The innate immune response to infections overlaps and cooperates with cellular stress signalling governed by the mitogen-activated protein kinase (MAPK) p38. Laura Boccuni in the group of Thomas Decker unravelled the molecular mechanism how macrophages merge the IFN JAK-STAT and the stress p38 MAPK pathways to […]
The JAK-STAT signaling pioneers James E Darnell, John J O‘Shea and George R Stark and former or current co-workers in their labs co-author a comprehensive review on the current knowledge on the cellular and systemic activities of JAKs and STATs and possibilities of their therapeutic targeting in disease settings (see https://doi.org/10.1016/j.cell.2022.09.023). The Viennese JAK-STAT community […]
