Molecular Pathology and TYK2 Activity During Endotoxin-induced Hyperinflammation

The SFB members Birgit Strobl, Mathias Müller and Richard Moriggl show in complex mouse models and human cells the pivotal role of TYK2 in the development of severe organ damage during endotoxemia. Mechanistically the TYK2-dependent pathology was driven by murine caspase-11 (CASP11) or the human homolog CASP5 activity and the subsequent release of IL-1ß and IL-18. […]

Distinct Functions of STAT1 Isoforms in NK Cell Maturation and Cytotoxicity

Using sophisticated genetically engineered mouse models the SFB members Birgit Strobl, Mathias Müller and Veronika Sexl further dissect the NK cell-intrinsic and -extrinsic requirements for STAT1a versus STAT1b in NK cell biology and tumor surveillance. Published in Frontiers in Immunology Kartin Meissl, Natalija Simonović, Lena Amenitsch, Agnieszka Witalisz-Siepracka, Klara Klein, Caroline Lassnig, Ana Puga, Claus […]

Therapeutic targeting of STAT3 by monobodies

Therapeutic targeting of STAT3 by monobodies An international consortium headed by the Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences ETH Lausanne collaborated with Veronika Sexl group members and developed the first monobodies targeted against STAT3. Monobodies are synthetic binding proteins engineered to selectively bind intracellular proteins – also those lacking an […]

Combining the predictive power of deep learning with the interpretability of cell signaling networks

Nikolaus Fortelny and Christoph Bock of CeMM showed the usefulness of knowledge-primed neural networks (KPNNs) for the interpretation of single-cell RNA-seq data. They expect that the use of deep learning on biological networks will also be relevant in other areas of biomedicine analysing big data sets, including metabolomics, proteomics and cellular or cognitive networks. Published […]

Special Issue ‚Targeting STAT3 and STAT5 in Cancer’

Special Issue ‚Targeting STAT3 and STAT5 in Cancer’ with Guest Editors Richard Moriggl (Vienna, AT), Patrick Gunning (Toronto, CA) and György Miklós Keserü (Budapest, HU). The Editorial of this Special Issue of Cancers (Basel) is now published: https://www.mdpi.com/2072-6694/12/8/2002. The Special Issue contains various contributions of SFB members and associate members: https://www.mdpi.com/journal/cancers/special_issues/STAT_cancers

Comprehensive Analysis of the Chromatin Landscapes of Structural Non-Haematopoietic Cells

The mammalian immune system implements a remarkably effective set of mechanisms for fighting pathogens. Its main components are haematopoietic immune cells, including myeloid cells that control innate immunity, and lymphoid cells that constitute adaptive immunity. However, immune functions are not unique to haematopoietic cells, and many other cell types display basic mechanisms of pathogen defence. […]

New therapy for aggressive leukemia with poor prognosis

Acute myeloid leukemia (AML) is an aggressive form of blood cancer that affects children and adults. In cases with particularly poor prognosis, this cancer is triggered by oncogenic fusion proteins, the formation of which involves the Nucleoporin 98 (NUP98) gene. A study published in the journal Blood results from a collaborative effort, including the groups of Richard […]

Vetmeduni Vienna establishes the research platform "PeptAIDes"

The Science Fund FWF supports promising research projects with a total volume of 8.6 million euros, in collaboration with the Austrian Academy of Sciences (ÖAW). This is intended to promote the innovative and interdisciplinary collaboration of outstanding postdoc teams from Austrian universities. One of the approved “Zukunftskollegs” will be carried out by member of the Vetmeduni Vienna in the field of […]

New findings that are relevant for the treatment of human diseases

New findings from researchers at the Department for Functional Cancer Genomics at the Vetmeduni Vienna, in cooperation with the Technical University of Denmark (DTU), provide insights into mechanisms of immune cells that could affect future therapies for human diseases. The study called “The neonatal microenvironment programs innate γδ T cells through the transcription factor STAT5“ includes the participation of […]

Klara Klein receives DOC scholarship from the ÖAW

Klara Klein from the Institute of Pharmacology and Toxicology at the Vetmeduni in Vienna received the DOC grant from the Austrian Academy of Sciences to develop her project “Oncogenic mechanisms of mutant STAT5B in natural killer cells” over the next two years. With the funding program “DOC”, the Austrian Academy of Sciences (ÖAW) supports highly […]