We think that the body of published results over a considerable period of time represents an important aspect of the visibility and impact of a given research team has in the field.
Here we present the publications, which are based on the research at least with partial funding from the current SFB-F61 “Hierarchies and Monarchies” and its predecessor, SFB-F28 “Jak-Stat Signalling: from Basics to Disease”. Due to the extensive time publications require to become published we manuscripts frequently become published beyond the lifetime of individual projects.
2024 Publications
| Moorlag, S., Folkman, L., Ter Horst, R., Krausgruber, T., Barreca, D., Schuster, L.C., Fife, V., Matzaraki, V., Li, W., Reichl, S., Mourits, V.P., Koeken, V., de Bree, L.C.J., Dijkstra, H., Lemmers, H., van Cranenbroek, B., van Rijssen, E., Koenen, H., Joosten, I., Xu, C.J., Li, Y., Joosten, L.A.B., van Crevel, R., Netea, M.G., and Bock, C. Multi-omics analysis of innate and adaptive responses to BCG vaccination reveals epigenetic cell states that predict trained immunity. DOI 10.1016/j.immuni.2023.12.005. |
| Redl, A., Doberer, K., Unterluggauer, L., Kleissl, L., Krall, C., Mayerhofer, C., Reininger, B., Stary, V., Zila, N., Weninger, W., Weichhart, T., Bock, C., Krausgruber, T., and Stary, G. Efficacy and safety of mTOR inhibition in cutaneous sarcoidosis: a single-centre trial. DOI 10.1016/S2665-9913(23)00302-8 |
| Zhang, D., Tang, W., Niu, H., Tse, W., Ruan, H.B., Dolznig, H., Knösel, T., Karl-Heinz, F., Themanns, M., Wang, J., Song, M., Denson, L., Kenner, L., Moriggl, R., Zheng, Y., and Han, X. Monogenic deficiency in murine intestinal Cdc42 leads to mucosal inflammation that induces crypt dysplasia. DOI 10.1016/j.gendis.2022.11.024 |
2023 Publications
| Brandstoetter, T., Schmoellerl, J., Grausenburger, R., Kollmann, S., Doma, E., Huuhtanen, J., Klampfl, T., Eder, T., Grebien, F., Hoermann, G., Zuber, J., Mustjoki, S., Maurer, B., and Sexl, V. SBNO2 is a critical mediator of STAT3-driven hematological malignancies. DOI 10.1182/blood.2022018494 |
| Cronin, S.J.F., Tejada, M.A., Song, R., Laval, K., Cikes, D., Ji, M., Brai, A., Stadlmann, J., Novatchikova, M., Perlot, T., Ali, O.H., Botta, L., Decker, T., Lazovic, J., Hagelkruys, A., Enquist, L., Rao, S., Koyuncu, O.O., and Penninger, J.M. Pseudorabies virus hijacks DDX3X, initiating an addictive "mad itch" and immune suppression, to facilitate viral spread. DOI 10.1101/2023.05.09.539956. |
| Fischer, K., Bradlerova, M., Decker, T., and Supper, V. V?9+V?2+?T cell control of Listeria monocytogenes growth in infected epithelial cells requires butyrophilin 3A genes DOI 10.1038/s41598-023-45587-1 |
| Krausgruber, T., Redl, A., Barreca, D., Doberer, K., Romanovskaia, D., Dobnikar, L., Guarini, M., Unterluggauer, L., Kleissl, L., Atzmüller, D., Mayerhofer, C., Kopf, A., Saluzzo, S., Lim, C.X., Rexie, P., Weichhart, T., Bock, C., and Stary, G. Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation. DOI 10.1016/j.immuni.2023.01.014. |
| Schwartz, I., Vunjak, M., Budroni, V., Cantoran García, A., Mastrovito, M., Soderholm, A., Hinterndorfer, M., de Almeida, M., Hacker, K., Wang, J., Froussios, K., Jude, J., Decker, T., Zuber, J., and Versteeg, G.A. SPOP targets the immune transcription factor IRF1 for proteasomal degradation. DOI 10.7554/eLife.89951 |
| Sukhbaatar, N., Schöller, M., Fritsch, S.D., Linke, M., Horer, S., Träger, M., Mazic, M., Forisch, S., Gonzales, K., Kahler, J.P., Binder, C., Lassnig, C., Strobl, B., Mueller, M., Scheiber-Mojdehkar, B., Gundacker, C., Dabsch, S., Kain, R., Hengstschläger, M., Verhelst, S., Weiss, S., Theurl, I., and Weichhart, T. Duodenal macrophages control dietary iron absorption via local degradation of transferrin. DOI 10.1182/blood.2022018494. |
| Woess, K., Macho-Maschler, S., Van Ingen Schenau, D.S., Butler, M., Lassnig, C., Valcanover, D., Poelzl, A., Meissl, K., Maurer, B., Brandstoetter, T., Vogl, C., Koren, A., Kubicek, S., Orlova, A., Moriggl, R., Strobl, B., Sexl, V., Van Leeuwen, F.N., Kuiper, R.P., and Mueller, M. Oncogenic TYK2(P760L) kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade. DOI doi.org/10.3324/haematol.2021.279848 |
2022 Publications
| Woess, K., Macho-Maschler, S., Van Ingen Schenau, D.S., Butler, M., Lassnig, C., Valcanover, D., Poelzl, A., Meissl, K., Maurer, B., Brandstoetter, T., Vogl, C., Koren, A., Kubicek, S., Orlova, A., Moriggl, R., Strobl, B., Sexl, V., Van Leeuwen, F.N., Kuiper, R.P., and Mueller, M. Oncogenic TYK2(P760L) kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade Haematologica 2022 Jan 13. doi: 10.3324/haematol.2021.279848 |
| Erdogan, F., Qadree, A.K., Radu, T.B., Orlova, A., de Araujo, E.D., Moriggl, R., and Gunning, P.T. Structural and mutational analysis of member-specific STAT functions Biochim Biophys Acta Gen Subj 1866, 130058. Doi: 10.1016/j.bbagen.2021.130058 |
| Gawish, R., Starkl, P., Pimenov, L., Hladik, A., Lakovits, K., Oberndorfer, F., Cronin, S.J., Ohradanova-Repic, A., Wirnsberger, G., Agerer, B., Endler, L., Capraz, T., Perthold, J.W., Cikes, D., Koglgruber, R., Hagelkruys, A., Montserrat, N., Mirazimi, A., Boon, L., Stockinger, H., Bergthaler, A., Oostenbrink, C., Penninger, J.M., and Knapp, S. ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology Elife 11, e74623. Doi: 10.7554/eLife.74623 |
| Bayer, N., Hausman, B., Pandey, R.V., Deckert, F., Gail, L.M., Strobl, J., Pjevac, P., Krall, C., Unterluggauer, L., Redl, A., Bachmayr, V., Kleissl, L., Nehr, M., Kirkegaard, R., Makristathis, A., Watzenboeck, M.L., Nica, R., Staud, C., Hammerl, L., Wohlfarth, P., Ecker, R.C., Knapp, S., Rabitsch, W., Berry, D., and Stary, G. Disturbances in microbial skin recolonization and cutaneous immune response following allogeneic stem cell transfer. Doi: 10.1038/s41375-022-01712-z |
| Boccuni, L., Podgorschek, E., Schmiedeberg, M., Platanitis, E., Traxler, P., Fischer, P., Schirripa, A., Novoszel, P., Nebreda, A.R., Arthur, J.S.C., Fortelny, N., Farlik, M., Sexl, V., Bock, C., Sibilia, M., Kovarik, P., Mueller, M., and Decker, T. Stress signaling boosts interferon-induced gene transcription in macrophages. DOI 10.1126/scisignal.abq5389 |
| Erdogan, F., Qadree, A.K., Radu, T.B., Orlova, A., de Araujo, E.D., Moriggl, R., and Gunning, P.T. Structural and mutational analysis of member-specific STAT functions DOI 10.1016/j.bbagen.2021.130058 |
| Erdogan, F., Radu, T.B., Orlova, A., Qadree, A.K., de Araujo, E.D., Israelian, J., Valent, P., Mustjoki, S.M., Herling, M., Moriggl, R., and Gunning, P.T. JAK-STAT core cancer pathway: An integrative cancer interactome analysis. DOI 10.1111/jcmm.17228 |
| Garcha, H.K., Nawar, N., Sorger, H., Erdogan, F., Aung, M.M.K., Sedighi, A., Manaswiyoungkul, P., Seo, H.S., Schönefeldt, S., Pölöske, D., Dhe-Paganon, S., Neubauer, H.A., Mustjoki, S.M., Herling, M., de Araujo, E.D., Moriggl, R., and Gunning, P.T. High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma. DOI 10.3390/ph15111321 |
| Gawish, R., Maier, B., Obermayer, G., Watzenboeck, M.L., Gorki, A.D., Quattrone, F., Farhat, A., Lakovits, K., Hladik, A., Korosec, A., Alimohammadi, A., Mesteri, I., Oberndorfer, F., Oakley, F., Brain, J., Boon, L., Lang, I., Binder, C.J., and Knapp, S. A neutrophil-B-cell axis impacts tissue damage control in a mouse model of intraabdominal bacterial infection via Cxcr4. DOI 10.7554/eLife.78291 |
| Gawish, R., Starkl, P., Pimenov, L., Hladik, A., Lakovits, K., Oberndorfer, F., Cronin, S.J., Ohradanova-Repic, A., Wirnsberger, G., Agerer, B., Endler, L., Capraz, T., Perthold, J.W., Cikes, D., Koglgruber, R., Hagelkruys, A., Montserrat, N., Mirazimi, A., Boon, L., Stockinger, H., Bergthaler, A., Oostenbrink, C., Penninger, J.M., and Knapp, S. ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFN?-driven immunopathology. DOI 10.7554/eLife.74623 |
| Goh, P.K., Wiede, F., Zeissig, M.N., Britt, K.L., Liang, S., Molloy, T., Goode, N., Xu, R., Loi, S., Muller, M., Humbert, P.O., McLean, C., and Tiganis, T. PTPN2 elicits cell autonomous and non-cell autonomous effects on antitumor immunity in triple-negative breast cancer. DOI 10.1111/jcmm.17228 |
| Hendrikx, T., Porsch, F., Kiss, M.G., Rajcic, D., Papac-Mili?evi?, N., Hoebinger, C., Göderle, L., Hladik, A., Shaw, L.E., Horstmann, H., Knapp, S., Derdak, S., Bilban, M., Heintz, L., Krawczyk, M., Paternostro, R., Trauner, M., Farlik, M., Wolf, D., and Binder, C.J. Soluble TREM2 levels reflect the recruitment and expansion of TREM2(+) macrophages that localize to fibrotic areas and limit NASH DOI 10.1016/j.jhep.2022.06.004. |
| Moritsch, S., Mödl, B., Scharf, I., Janker, L., Zwolanek, D., Timelthaler, G., Casanova, E., Sibilia, M., Mohr, T., Kenner, L., Herndler-Brandstetter, D., Gerner, C., Müller, M., Strobl, B., and Eferl, R. Tyk2 is a tumor suppressor in colorectal cancer. DOI 10.1080/2162402X.2022.2127271 |
| Platanitis, E., Gruener, S., Ravi Sundar Jose Geetha, A., Boccuni, L., Vogt, A., Novatchkova, M., Sommer, A., Barozzi, I., Müller, M., and Decker, T Interferons reshape the 3D conformation and accessibility of macrophage chromatin. DOI 10.1016/j.isci.2022.103840 |
| Sorger, H., Dey, S., Vieyra-Garcia, P.A., Pölöske, D., Teufelberger, A.R., de Araujo, E.D., Sedighi, A., Graf, R., Spiegl, B., Lazzeri, I., Braun, T., Garces de Los Fayos Alonso, I., Schlederer, M., Timelthaler, G., Kodajova, P., Pirker, C., Surbek, M., Machtinger, M., Graier, T., Perchthaler, I., Pan, Y., Fink-Puches, R., Cerroni, L., Ober, J., Otte, M., Albrecht, J.D., Tin, G., Abdeldayem, A., Manaswiyoungkul, P., Olaoye, O.O., Metzelder, M.L., Orlova, A., Berger, W., Wobser, M., Nicolay, J.P., André, F., Nguyen, V.A., Neubauer, H.A., Fleck, R., Merkel, O., Herling, M., Heitzer, E., Gunning, P.T., Kenner, L., Moriggl, R., and Wolf, P. Blocking STAT3/5 through direct or upstream kinase targeting in leukemic cutaneous T-cell lymphoma DOI 10.15252/emmm.202115200 |
| Zahalka, S., Starkl, P., Watzenboeck, M.L., Farhat, A., Radhouani, M., Deckert, F., Hladik, A., Lakovits, K., Oberndorfer, F., Lassnig, C., Strobl, B., Klavins, K., Matsushita, M., Sanin, D.E., Grzes, K.M., Pearce, E.J., Gorki, A., and Knapp, S. Trained immunity of alveolar macrophages requires metabolic rewiring and type 1 interferon signaling. DOI 10.1038/s41385-022-00528-5 |
2021 Publications
| Poelzl, A., Lassnig, C., Tangermann, S., Hromadová, D., Reichart, U., Gawish, R., Mueller, K., Moriggl, R., Linkermann, A., Glösmann, M., Kenner, L., Mueller, M., and Strobl, B., TYK2 licenses non-canonical inflammasome activation during endotoxemia Cell Death Diff 2020 Sep 14. doi: 10.1038/s41418-020-00621-x |
| Pezoldt, J., Wiechers, C., Erhard, F., Rand, U., Bulat, T., Beckstette, M., Brendolan, A., Huehn, J., Kalinke, U., Mueller, M., Strobl, B., Deplancke, B., ÄŒiÄin-Å ain, L., and Sitnik, K.M. Single-cell transcriptional profiling of splenic fibroblasts reveals subset-specific innate immune signatures in homeostasis and during viral infection Commun Biol 2021 Dec 4, 1355. doi: 10.1038/s42003-021-02882-9 |
| Jaggi, U., Matundan, H.H., Yu, J., Hirose, S., Mueller, M., Wormley, F.L., and Ghiasi, H. Essential role of M1 macrophages in blocking cytokine storm and pathology associated with murine HSV-1 infection PLoS Pathog 2021 Oct. 17, e100999. doi: 10.1371/journal.ppat.1009999 |
| De Vries, L. C. S., Ghiboub, M., van Hamersveld, P. H. P., Welting, O., Verseijden, C., Bell, M. J., Rioja, I., Prinjha, R. K., Koelink, P. J., Strobl, B., Mueller, M., D'Haens, G. R., Wildenberg, M. E., and De Jonge, W.J. Tyrosine Kinase 2 signalling drives pathogenic T-cells in colitis J Crohns Colitis 2021 Apr 15, 617-630. doi: 10.1093/ecco-jcc/jjaa199 |
| Demiroz, D., Platanitis, E., Bryant, M., Fischer, P., Prchal-Murphy, M., Lercher, A., Lassnig, C., Baccarini, M., Mueller, M., Bergthaler, A., Sexl, V., Dolezal, M., and Decker, T. Listeria monocytogenes infection rewires host metabolism with regulatory input from type I interferons PLoS Pathog 2021 Jul 8;17, e1009697. doi: 10.1371/journal.ppat.1009697 |
| Watzenboeck, M.L., Drobits, B., Zahalka, S., Gorki, A.D., Farhat, A., Quattrone, F., Hladik, A., Lakovits, K., Richard, G.M., Lederer, T., Strobl, B., Versteeg, G.A., Boon, L., Starkl, P., and Knapp, S. Lipocalin 2 modulates dendritic cell activity and shapes immunity to influenza in a microbiome dependent manner PLoS Pathog 17, e1009487. Doi: 10.1371/journal.ppat.1009487 |
| Schroeder, J.H., Roberts, L.B., Meissl, K., Lo, J.W., Hromadová, D., Hayes, K., Zabinski, T., Read, E., Moreira Heliodoro, C., Reis, R., Howard, J.K., Grencis, R.K., Neves, J.F., Strobl, B., and Lord, G.M. Sustained Post-Developmental T-Bet Expression Is Critical for the Maintenance of Type One Innate Lymphoid Cells In Vivo Front Immunol 12, 760198. Doi: 10.3389/fimmu.2021.760198 |
| Schroeder, J.-H., Meissl, K., Hromadová, D., Lo, J.W., Neves, J.F., Howard, J.K., Helmby, H., Powell, N., Strobl, B., and Lord, G.M. T-Bet Controls Cellularity of Intestinal Group 3 Innate Lymphoid Cells Front Immunol 11, 623324. Doi: 10.3389/fimmu.2020.623324 |
| Schnepf, D., Crotta, S., Thamamongood, T., Stanifer, M., Polcik, L., Ohnemus, A., Vier, J., Jakob, C., Llorian, M., Gad, H.H., Hartmann, R., Strobl, B., Kirschnek, S., Boulant, S., Schwemmle, M., Wack, A., and Staeheli, P. Selective Janus kinase inhibition preserves interferon-λ-mediated antiviral responses Sci Immunol 6, eabd5318. Doi: 10.1126/sciimmunol.abd5318 |
| Tripolt, S., Neubauer, H.A., Knab, V.M., Elmer, D.P., Aberger, F., Moriggl, R., and Fux, D.A. Opioids drive breast cancer metastasis through the δ-opioid receptor and oncogenic STAT3 Neoplasia 23, 270-279. Doi: 10.1016/j.neo.2020.12.011 |
| Toutah, K., Nawar, N., Timonen, S., Sorger, H., Raouf, Y.S., Bukhari, S., von Jan, J., Ianevski, A., Gawel, J.M., Olaoye, O.O., Geletu, M., Abdeldayem, A., Israelian, J., Radu, T.B., Sedighi, A., Bhatti, M.N., Hassan, M.M., Manaswiyoungkul, P., Shouksmith, A.E., Neubauer, H.A., de Araujo, E.D., Aittokallio, T., Krämer, O.H., Moriggl, R., Mustjoki, S., Herling, M., and Gunning, P.T. Development of HDAC Inhibitors Exhibiting Therapeutic Potential in T-Cell Prolymphocytic Leukemia J Med Chem 64, 8486-8509. doi: 10.1021/acs.jmedchem.1c00420 |
| Swoboda, A., Soukup, R., Eckel, O., Kinslechner, K., Wingelhofer, B., Schörghofer, D., Sternberg, C., Pham, H.T.T., Vallianou, M., Horvath, J., Stoiber, D., Kenner, L., Larue, L., Poli, V., Beermann, F., Yokota, T., Kubicek, S., Krausgruber, T., Rendeiro, A.F., Bock, C., Zenz, R., Kovacic, B., Aberger, F., Hengstschläger, M., Petzelbauer, P., Mikula, M., and Moriggl, R. STAT3 promotes melanoma metastasis by CEBP-induced repression of the MITF pathway Oncogene 40, 1091-1105. Doi: 10.1038/s41388-020-01584-6 |
| Surbek, M., Tse, W., Moriggl, R., and Han, X. A centric view of JAK/STAT5 in intestinal homeostasis, infection, and inflammation Cytokine 139, 155392. Doi: 10.1016/j.cyto.2020.155392 |
| Schönefeldt, S., Wais, T., Herling, M., Mustjoki, S., Bekiaris, V., Moriggl, R., and Neubauer, H.A. The Diverse Roles of γδ T Cells in Cancer: From Rapid Immunity to Aggressive Lymphoma Cancers (Basel) 13, 6212. Doi: 10.3390/cancers13246212 |
| Pons, M., Zeyn, Y., Zahn, S., Mahendrarajah, N., Page, B.D.G., Gunning, P.T., Moriggl, R., Brenner, W., Butter, F., and Krämer, O.H. Oncogenic Kinase Cascades Induce Molecular Mechanisms That Protect Leukemic Cell Models from Lethal Effects of De Novo dNTP Synthesis Inhibition Cancers 13, 3464. Doi: doi:10.3390/cancers13143464 |
| Kollmann, S., Grausenburger, R., Klampfl, T., Prchal-Murphy, M., Bastl, K., Pisa, H., Knab, V.M., Brandstoetter, T., Doma, E., Sperr, W.R., Lagger, S., Farlik, M., Moriggl, R.H., Valent, P., Halbritter, F., Kollmann, K., Heller, G., Maurer, B., and Sexl, V. A STAT5B-CD9 axis determines self-renewal in hematopoietic and leukemic stem cells Blood 138, 2347-2359. Doi: 10.1182/blood.2021010980 |
| Kim, D., Park, G., Huuhtanen, J., Ghimire, B., Rajala, H., Moriggl, R., Chan, W.C., Kankainen, M., Myllymäki, M., and Mustjoki, S. STAT3 activation in large granular lymphocyte leukemia is associated with cytokine signaling and DNA hypermethylation Leukemia 35, 3430-3443. Doi: 10.1038/s41375-021-01296-0 |
| Kieslinger, M., Swoboda, A., Kramer, N., Freund, P., Pratscher, B., Neubauer, H.A., Steinborn, R., Wolfesberger, B., Fuchs-Baumgartinger, A., Moriggl, R., and Burgener, I.A. A Recurrent STAT5B(N642H) Driver Mutation in Feline Alimentary T Cell Lymphoma Cancers (Basel) 13, 5238. Doi: 10.3390/cancers13205238 |
| Igelmann, S., Lessard, F., Uchenunu, O., Bouchard, J., Fernandez-Ruiz, A., Rowell, M.C., Lopes-Paciencia, S., Papadopoli, D., Fouillen, A., Ponce, K.J., Huot, G., Mignacca, L., Benfdil, M., Kalegari, P., Wahba, H.M., Pencik, J., Vuong, N., Quenneville, J., Guillon, J., Bourdeau, V., Hulea, L., Gagnon, E., Kenner, L., Moriggl, R., Nanci, A., Pollak, M.N., Omichinski, J.G., Topisirovic, I., and Ferbeyre, G. A hydride transfer complex reprograms NAD metabolism and bypasses senescence Mol Cell 81, 3848-3865.e3819. doi: 10.1016/j.molcel.2021.08.028 |
| Breitenecker, K., Homolya, M., Luca, A.C., Lang, V., Trenk, C., Petroczi, G., Mohrherr, J., Horvath, J., Moritsch, S., Haas, L., Kurnaeva, M., Eferl, R., Stoiber, D., Moriggl, R., Bilban, M., Obenauf, A.C., Ferran, C., Dome, B., Laszlo, V., Győrffy, B., Dezso, K., Moldvay, J., Casanova, E., and Moll, H.P. Down-regulation of A20 promotes immune escape of lung adenocarcinomas Sci Transl Med 13, eabv3911. Doi: 10.1126/scitranslmed.abc3911 |
| Bregante, J., Schönbichler, A., Pölöske, D., Degenfeld-Schonburg, L., Monzó Contreras, G., Hadzijusufovic, E., de Araujo, E.D., Valent, P., Moriggl, R., and Orlova, A. Efficacy and Synergy of Small Molecule Inhibitors Targeting FLT3-ITD(+) Acute Myeloid Leukemia Cancers (Basel) 13, 6381. Doi: 10.3390/cancers13246181 |
| Beghini, M., Wagner, T., Luca, A.C., Metz, M., Kaltenecker, D., Spirk, K., Hackl, M.T., Haybaeck, J., Moriggl, R., Kautzky-Willer, A., Scherer, T., and Fuernsinn, C. Adipocyte STAT5 deficiency does not affect blood glucose homeostasis in obese mice PLoS One 16, e0260501. Doi: 10.1371/journal.pone.0260501 |
| Klein, K., Witalisz-Siepracka, A., Gotthardt, D., Agerer, B., Locker, F., Grausenburger, R., Knab, V.M., Bergthaler, A., and Sexl, V. T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo Front Immunol 12, 650977. Doi: 10.3389/fimmu.2021.650977 |
| Gorki, A.D., Symmank, D., Zahalka, S., Lakovits, K., Hladik, A., Langer, B., Maurer, B., Sexl, V., Kain, R., and Knapp, S. Murine ex vivo Cultured Alveolar Macrophages Provide a Novel Tool to Study Tissue-Resident Macrophage Behavior and Function Am J Respir Cell Mol Biol 66, 64-75. Doi: 10.1165/rcmb.2021-0190OC |
| Maurer, B., Brandstoetter, T., Kollmann, S., Sexl, V., and Prchal-Murphy, M. Inducible deletion of CDK4 and CDK6 - deciphering CDK4/6 inhibitor effects in the hematopoietic system Haematologica 106, 2624-2632. Doi: 10.3324/haematol.2020.256313 |
| Esparza-Baquer, A., Labiano, I., Sharif, O., Agirre-Lizaso, A., Oakley, F., Rodrigues, P.M., Zhuravleva, E., O'Rourke, C.J., Hijona, E., Jimenez-Agueero, R., Riaño, I., Landa, A., La Casta, A., Zaki, M.Y.W., Munoz-Garrido, P., Azkargorta, M., Elortza, F., Vogel, A., Schabbauer, G., Aspichueta, P., Andersen, J.B., Knapp, S., Mann, D.A., Bujanda, L., Banales, J.M., and Perugorria, M.J. TREM-2 defends the liver against hepatocellular carcinoma through multifactorial protective mechanisms Gut 70, 1345-1361. doi: 10.1136/gutjnl-2019-319227 |
| Novoszel, P., Drobits, B., Holcmann, M., Fernandes, C.S., Tschismarov, R., Derdak, S., Decker, T., Wagner, E.F., and Sibilia, M. The AP-1 transcription factors c-Jun and JunB are essential for CD8α conventional dendritic cell identity Cell Death Differ 28, 2404-2420. doi: 10.1038/s41418-021-00765-4 |
| Decker, T. The early interferon catches the SARS-CoV-2 J Exp Med 218, e20211667. doi: 10.1084/jem.20211667 |
| Rindler, K., Jonak, C., Alkon, N., Thaler, F.M., Kurz, H., Shaw, L.E., Stingl, G., Weninger, W., Halbritter, F., Bauer, W.M., Farlik, M., and Brunner, P.M. Single-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma Mol Cancer 20, 124. Doi: 10.1186/s12943-021-01419-2 |
| Rindler, K., Bauer, W.M., Jonak, C., Wielscher, M., Shaw, L.E., Rojahn, T.B., Thaler, F.M., Porkert, S., Simonitsch-Klupp, I., Weninger, W., Mayerhoefer, M.E., Farlik, M., and Brunner, P.M. Single-Cell RNA Sequencing Reveals Tissue Compartment-Specific Plasticity of Mycosis Fungoides Tumor Cells Front Immunol 12, 666935. Doi: 10.3389/fimmu.2021.666935 |
| Jonak, C., Alkon, N., Rindler, K., Rojahn, T.B., Shaw, L.E., Porkert, S., Weninger, W., Trautinger, F., Stingl, G., Tschandl, P., Cerroni, L., Farlik, M., and Brunner, P.M. Single-cell RNAseq profiling in a patient with discordant primary cutaneous B and T cell lymphoma reveals micromilieu-driven immune skewing Br J Dermatol 185, 1013-1025. Doi: 10.1111/bjd.20512 |
| Datlinger, P., Rendeiro, A.F., Boenke, T., Senekowitsch, M., Krausgruber, T., Barreca, D., and Bock, C Ultra-high-throughput single-cell RNA sequencing and perturbation screening with combinatorial fluidic indexing Nat Methods 18, 635-642. Doi: 10.1038/s41592-021-01153-z |
2020 Publications
| Vargas-Hernandez, A., Witalisz-Siepracka, A., Prchal-Murphy, M., Klein, K., Mahapatra, S., Al-Herz, W., Mace, E. M., Carisey, A. F., Orange, J. S., Sexl, V. and Forbes, L. R. Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function J Allergy Clin Immunol. 2019 Oct 7. pii: S0091-6749(19)31252-7. doi: 10.1016/j.jaci.2019.09.016 |
| Unterleuthner, D., Neuhold, P., Schwarz, K., Janker, L., Neuditschko, B., Nivarthi, H., Crncec, I., Kramer, N., Unger, C., Hengstschlager, M., Eferl, R., Moriggl, R., Sommergruber, W., Gerner, C. and Dolznig, H. Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer Angiogenesis. 2019 Oct 30. pii: 10.1007/s10456-019-09688-8. doi: 10.1007/s10456-019-09688-8 |
| Schmoellerl, J., Barbosa, I. A. M., Eder, T., Brandstoetter, T., Schmidt, L., Maurer, B., Troester, S., Pham, H. T. T., Sagarajit, M., Ebner, J., Manhart, G., Aslan, E., Terlecki-Zaniewicz, S., Van der Veen, C., Hoermann, G., Duployez, N., Petit, A., Lapillonne, H., Puissant, A., Itzykson, R. A., Moriggl, R. H., Heuser, M., Meisel, R., Valent, P., Sexl, V., Zuber, J. and Grebien, F. CDK6 is an essential direct target of NUP98-fusion proteins in acute myeloid leukemia Blood. 2020 Apr 28. pii: 454667. doi: 10.1182/blood.2019003267 |
| Pedersen, M.S., Mueller, M., Ruelicke, T., Leitner, N., Kain, R., Regele, H., Wang, S., Groene, H.-J., Haller, H., Gueler, F., Rees, A.J. and Kerjaschki, D. Lymphangiogenesis in experimental renal transplant rejection extends life span of the recipients in a mouse model Kidney Int. 2019 Sept 3;97(1):89-94. doi: 10.1016/ j.kint.2019.07.027 |
| Maurer, B., Nivarthi, H., Wingelhofer, B., Pham, H. T. T., Schlederer, M., Suske, T., Grausenburger, R., Schiefer, A. I., Prchal-Murphy, M., Chen, D., Winkler, S., Merkel, O., Kornauth, C., Hofbauer, M., Hochgatterer, B., Hoermann, G., Hoelbl-Kovacic, A., Prochazkova, J., Lobello, C., Cumaraswamy, A. A., Latzka, J., Kitzwogerer, M., Chott, A., Janikova, A., Pospisilova, S., Loizou, J. I., Kubicek, S., Valent, P., Kolbe, T., Grebien, F., Kenner, L., Gunning, P. T., Kralovics, R., Herling, M., Muller, M., Rulicke, T., Sexl, V. and Moriggl, R. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia Haematologica. 2019 May 23. pii: haematol.2019.216986. doi: 10.3324/haematol.2019.216986 |
| Lehmann, F. M., von Burg, N., Ivanek, R., Teufel, C., Horvath, E., Peter, A., Turchinovich, G., Staehli, D., Eichlisberger, T., Gomez de Aguero, M., Coto-Llerena, M., Prchal-Murphy, M., Sexl, V., Bentires-Alj, M., Mueller, C. and Finke, D. Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation Nat Commun. 2020 Apr 14;11(1):1794. doi: 10.1038/s41467-020-15612-2 |
| Karjalainen, A., Shoebridge, S., Krunic, M., Simonovic, N., Tebb, G., Macho-Maschler, S., Strobl, B. and Mueller, M. TYK2 in Tumor Immunosurveillance Cancers (Basel). 2020 Jan 8; 12 (1):E150. 10.3390/cancers12010150 |
| Kadekar, D., Agerholm, R., Rizk, J., Neubauer, H. A., Suske, T., Maurer, B., Vinals, M. T., Comelli, E. M., Taibi, A., Moriggl, R. and Bekiaris, V. The neonatal microenvironment programs innate gammadelta T cells through the transcription factor STAT5 J Clin Invest. 2020 Apr 13. pii: 131241. doi: 10.1172/JCI131241 |
| Hadzijusufovic, E., Keller, A., Berger, D., Greiner, G., Wingelhofer, B., Witzeneder, N., Ivanov, D., Pecnard, E., Nivarthi, H., Schur, F. K. M., Filik, Y., Kornauth, C., Neubauer, H. A., Mullauer, L., Tin, G., Park, J., de Araujo, E. D., Gunning, P. T., Hoermann, G., Gouilleux, F., Kralovics, R., Moriggl, R. and Valent, P. STAT5 is Expressed in CD34(+)/CD38(-) Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms Cancers (Basel). 2020 Apr 21;12(4). pii: cancers12041021. doi: 10.3390/cancers12041021 |
| Gracey, E., Hromadova, D., Lim, M., Qaiyum, Z., Zeng, M., Yao, Y., Srinath, A., Baglaenko, Y., Yeremenko, N., Westlin, W., Masse, C., Muller, M., Strobl, B., Miao, W. and Inman, R. D. TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis J Clin Invest. 2020 Mar 9. pii: 126567. doi: 10.1172/JCI126567 |
| Abdeldayem, A., Raouf, Y. S., Constantinescu, S. N., Moriggl, R. and Gunning, P. T. Advances in covalent kinase inhibitors Chem Soc Rev. 2020 Mar 30. doi: 10.1039/c9cs00720b |
| Roewe, J., Stavrides, G., Strueve, M., Sharma, A., Marini, F., Mann, A., Smith, S.A., Kaya, Z., Strobl, B., Mueller, M., Reinhardt, C., Morrissey, J.H., and Bosmann, M. Bacterial polyphosphates interfere with the innate host defense to infection Nat Commun 11, 4035. Doi: 10.1038/s41467-020-17639-x |
| Pfluegler, S., Svinka, J., Scharf, I., Crncec, I., Filipits, M., Charoentong, P., Tschurtschenthaler, M., Kenner, L., Awad, M., Stift, J., Schernthanner, M., Bischl, R., Herndler-Brandstetter, D., Glitzner, E., Moll, H.P., Casanova, E., Timelthaler, G., Sibilia, M., Gnant, M., Lax, S., Thaler, J., Mueller, M., Strobl, B., Mohr, T., Kaser, A., Trajanoski, Z., Heller, G., and Eferl, R. IDO1+ Paneth cells promote immune escape of colorectal cancer Commun Biol 3, 252. Doi: 10.1038/s42003-020-0989-y |
| Meissl, K., Simonovic, N., Amenitsch, L., Witalisz-Siepracka, A., Klein, K., Lassnig, C., Puga, A., Vogl, C., Poelzl, A., Bosmann, M., Dohnal, A., Sexl, V., Mueller, M., and Strobl, B. STAT1 isoforms differentially regulate NK cell maturation and anti-tumour activity Front Immunol 11, 2189. Doi: 10.3389/fimmu.2020.02189 |
| Kaltenecker, D., Spirk, K., Ruge, F., Grebien, F., Herling, M., Rupprecht, A., Kenner, L., Pohl, E.E., Mueller, K.M., and Moriggl, R. STAT5 is required for lipid breakdown and beta-adrenergic responsiveness of brown adipose tissue Mol Metab 40, 101026. Doi: 10.1016/j.molmet.2020.101026 |
| de Araujo, E.D., Keserű, G.M., Gunning, P.T., and Moriggl, R. Targeting STAT3 and STAT5 in Cancer Cancers (Basel) 12, E2002. Doi: 10.3390/cancers12082002 |
| Aksoy, O., Pencik, J., Hartenbach, M., Moazzami, A.A., Schlederer, M., Balber, T., Varady, A., Philippe, C., Baltzer, P.A., Mazumder, B., Whitchurch, J.B., Roberts, C.J., Haitel, A., Herac, M., Susani, M., Mitterhauser, M., Marculescu, R., Stangl-Kremser, J., Hassler, M.R., Kramer, G., Shariat, S.F., Turner, S.D., Tichy, B., Oppelt, J., Pospisilova, S., Hartenbach, S., Tangermann, S., Egger, G., Neubauer, H.A., Moriggl, R., Culig, Z., Greiner, G., Hoermann, G., Hacker, M., Heery, D.M., Merkel, O., and Kenner, L. Thyroid and androgen receptor signaling are antagonized by CRYM in prostate cancer Int J Cancer 148, 731-747. Doi: 10.1002/ijc.33332 |
| La Sala, G., Michiels, C., Kuekenshöner, T., Brandstoetter, T., Maurer, B., Koide, A., Lau, K., Pojer, F., Koide, S., Sexl, V., Dumoutier, L., and Hantschel, O. Selective inhibition of STAT3 signaling using monobodies targeting the coiled-coil and N-terminal domains Nat Commun 11, 4115. Doi: 10.1038/s41467-020-17920-z |
| Fischer, K., Tschismarov, R., Pilz, A., Straubinger, S., Carotta, S., McDowell, A., and Decker, T. Cutibacterium acnes Infection Induces Type I Interferon Synthesis Through the cGAS-STING Pathway Front Immunol 11, 571334. doi: 10.3389/fimmu.2020.571334 |
| Romanov, R.A., Tretiakov, E.O., Kastriti, M.E., Zupancic, M., Häring, M., Korchynska, S., Popadin, K., Benevento, M., Rebernik, P., Lallemend, F., Nishimori, K., Clotman, F., Andrews, W.D., Parnavelas, J.G., Farlik, M., Bock, C., Adameyko, I., Hökfelt, T., Keimpema, E., and Harkany, T. Molecular design of hypothalamus development Nature 582, 246-252. Doi: 10.1038/s41586-020-2266-0 |
| Stary, V., Pandey, R.V., Strobl, J., Kleissl, L., Starlinger, P., Pereyra, D., Weninger, W., Fischer, G.F., Bock, C., Farlik, M., and Stary, G. A discrete subset of epigenetically primed human NK cells mediates antigen-specific immune responses Sci Immunol 5, eaba6232. Doi: 10.1126/sciimmunol.aba6232 |
| Marquina-Sanchez, B., Fortelny, N., Farlik, M., Vieira, A., Collombat, P., Bock, C., and Kubicek, S. Single-cell RNA-seq with spike-in cells enables accurate quantification of cell-specific drug effects in pancreatic islets Genome Biol 21, 106. Doi: 10.1186/s13059-020-02006-2 |
| Krausgruber, T., Fortelny, N., Fife-Gernedl, V., Senekowitsch, M., Schuster, L.C., Lercher, A., Nemc, A., Schmidl, C., Rendeiro, A.F., Bergthaler, A., and Bock, C. Structural cells are key regulators of organ-specific immune responses Nature 583, 296-302. Doi: 10.1038/s41586-020-2424-4 |
| Fortelny, N., and Bock, C. Knowledge-primed neural networks enable biologically interpretable deep learning on single-cell sequencing data Genome Biol 21, 190. Doi: 10.1186/s13059-020-02100-5 |
2019 Publications
| Gawish, R., Bulat, T., Biaggio, M., Lassnig, C., Bago-Horvath, Z., Macho-Maschler, S., Poelzl, A., Simonovic, N., Prchal-Murphy, M., Rom, R., Amenitsch, L., Ferrarese, L., Kornhoff, J., Lederer, T., Svinka, J., Eferl, R., Bosmann, M., Kalinke, U., Stoiber, D., Sexl, V., Krmpotic, A., Jonjic, S., Muller, M. and Strobl, B. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1 Cell Rep. 2019 Feb 26;26(9):2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017 |
| Kollmann, S., Grundschober, E., Maurer, B., Warsch, W., Grausenburger, R., Edlinger, L., Huuhtanen, J., Lagger, S., Hennighausen, L., Valent, P., Decker, T., Strobl, B., Mueller, M., Mustjoki, S., Hoelbl-Kovacic, A. and Sexl, V. Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia Leukemia. 2019 Jan 24. pii: 10.1038/s41375-018-0369-5. doi: 10.1038/s41375-018-0369-5 |
| Kosack, L., Wingelhofer, B., Popa, A., Orlova, A., Agerer, B., Vilagos, B., Majek, P., Parapatics, K., Lercher, A., Ringler, A., Klughammer, J., Smyth, M., Khamina, K., Baazim, H., de Araujo, E. D., Rosa, D. A., Park, J., Tin, G., Ahmar, S., Gunning, P. T., Bock, C., Siddle, H. V., Woods, G. M., Kubicek, S., Murchison, E. P., Bennett, K. L., Moriggl, R. and Bergthaler, A. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease Cancer Cell. 2019 Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018 |
| Rauth, M., Freund, P., Orlova, A., Grunert, S., Tasic, N., Han, X., Ruan, H. B., Neubauer, H. A. and Moriggl, R. Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival Int J Mol Sci. 2019 Feb 27;20(5). pii: ijms20051028. doi: 10.3390/ijms20051028 |
| Simonovic, N., Witalisz-Siepracka, A., Meissl, K., Lassnig, C., Reichart, U., Kolbe, T., Farlik, M., Bock, C., Sexl, V., Mueller, M. and Strobl, B. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity J Immunol. 2019 Feb 4. pii: jimmunol.1701649. doi: 10.4049/jimmunol.1701649 |
| Witalisz-Siepracka, A., Klein, K., Ptinz, D., Leidenfrost, N., Schabbauer, G., Dohnal, A. and Sexl, V. Loss of JAK1 Drives Innate Immune Deficiency Front Immunol. 2019; 9(3108). doi:10.3389/fimmu.2018.03108 |
| Liu, R., Moriggl, R., Zhang, D., Li, H., Karns, R., Ruan, H. B., Niu, H., Mayhew, C., Watson, C., Bangar, H., Cha, S. W., Haslam, D., Zhang, T., Gilbert, S., Li, N., Helmrath, M., Wells, J., Denson, L. and Han, X. Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis Life Sci Alliance. 2019 Apr 4;2(2). pii: 2/2/e201900296. doi: 10.26508/lsa.201900296 |
| Klein, K., Witalisz-Siepracka, A., Maurer, B., Prinz, D., Heller, G., Leidenfrost, N., Prchal-Murphy, M., Suske, T., Moriggl, R. and Sexl, V. STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia Leukemia. 2019 Apr 9. pii: 10.1038/s41375-019-0471-3. doi: 10.1038/s41375-019-0471-3 |
| de Araujo, E. D., Erdogan, F., Neubauer, H. A., Meneksedag-Erol, D., Manaswiyoungkul, P., Eram, M. S., Seo, H. S., Qadree, A. K., Israelian, J., Orlova, A., Suske, T., Pham, H. T. T., Boersma, A., Tangermann, S., Kenner, L., Rulicke, T., Dong, A., Ravichandran, M., Brown, P. J., Audette, G. F., Rauscher, S., Dhe-Paganon, S., Moriggl, R. and Gunning, P. T. Structural and functional consequences of the STAT5B(N642H) driver mutation Nat Commun. 2019 Jun 7;10(1):2517. doi: 10.1038/s41467-019-10422-7 |
| Maurer, B., Nivarthi, H., Wingelhofer, B., Pham, H. T. T., Schlederer, M., Suske, T., Grausenburger, R., Schiefer, A. I., Prchal-Murphy, M., Chen, D., Winkler, S., Merkel, O., Kornauth, C., Hofbauer, M., Hochgatterer, B., Hoermann, G., Hoelbl-Kovacic, A., Prochazkova, J., Lobello, C., Cumaraswamy, A. A., Latzka, J., Kitzwogerer, M., Chott, A., Janikova, A., Pospisilova, S., Loizou, J. I., Kubicek, S., Valent, P., Kolbe, T., Grebien, F., Kenner, L., Gunning, P. T., Kralovics, R., Herling, M., Muller, M., Rulicke, T., Sexl, V. and Moriggl, R. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia Haematologica. 2019 May 23. pii: haematol.2019.216986. doi: 10.3324/haematol.2019.216986 |
| Menzl, I., Witalisz-Siepracka, A. and Sexl, V. CDK8-Novel Therapeutic Opportunities Pharmaceuticals (Basel). 2019 Jun 19;12(2). pii: ph12020092. doi: 10.3390/ph12020092 |
| Platanitis, E., Demiroz, D., Schneller, A., Fischer, K., Capelle, C., Hartl, M., Gossenreiter, T., Muller, M., Novatchkova, M. and Decker, T. A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription Nat Commun. 2019 Jul 2;10(1):2921. doi: 10.1038/s41467-019-10970-y |
| Aigner, P., Mizutani, T., Horvath, J., Eder, T., Heber, S., Lind, K., Just, V., Moll, H. P., Yeroslaviz, A., Fischer, M. J. M., Kenner, L., Gyorffy, B., Sill, H., Grebien, F., Moriggl, R., Casanova, E. and Stoiber, D. STAT3beta is a tumor suppressor in acute myeloid leukemia Blood Adv. 2019 Jul 9;3(13):1989-2002. doi: 10.1182/bloodadvances.2018026385 |
| Boutillon, F., Pigat, N., Sala, L. S., Reyes-Gomez, E., Moriggl, R., Guidotti, J. E. and Goffin, V. STAT5a/b Deficiency Delays, but does not Prevent, Prolactin-Driven Prostate Tumorigenesis in Mice Cancers (Basel). 2019 Jul 2;11(7). pii: cancers11070929. doi: 10.3390/cancers11070929 |
| Prutsch, N., Gurnhofer, E., Suske, T., Liang, H. C., Schlederer, M., Roos, S., Wu, L. C., Simonitsch-Klupp, I., Alvarez-Hernandez, A., Kornauth, C., Leone, D. A., Svinka, J., Eferl, R., Limberger, T., Aufinger, A., Shirsath, N., Wolf, P., Hielscher, T., Aberger, F., Schmoellerl, J., Stoiber, D., Strobl, B., Jager, U., Staber, P. B., Grebien, F., Moriggl, R., Muller, M., Inghirami, G. G., Sanda, T., Look, A. T., Turner, S. D., Kenner, L. and Merkel, O. Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma Leukemia. 2018 Aug 21. pii: 10.1038/s41375-018-0239-1. doi: 10.1038/s41375-018-0239-1 |
| Orlova, A., Neubauer, H. A. and Moriggl, R. The stromal microenvironment provides an escape route from FLT3 inhibitors through the GAS6-AXL-STAT5 axis Haematologica. 2019 Oct;104(10):1907-1909. doi: 10.3324/haematol.2019.225862 |
| Klein, K., Witalisz-Siepracka, A., Maurer, B., Prinz, D., Heller, G., Leidenfrost, N., Prchal-Murphy, M., Suske, T., Moriggl, R. and Sexl, V. STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia Leukemia. 2019 Apr 9. pii: 10.1038/s41375-019-0471-3. doi: 10.1038/s41375-019-0471-3 |
| Orlova, A., Wagner, C., de Araujo, E. D., Bajusz, D., Neubauer, H. A., Herling, M., Gunning, P. T., Keseru, G. M. and Moriggl, R. Direct Targeting Options for STAT3 and STAT5 in Cancer Cancers (Basel). 2019 Dec 3;11(12). pii: cancers11121930. doi: 10.3390/cancers11121930 |
| Menzl, I., Zhang, T., Berger-Becvar, A., Grausenburger, R., Heller, G., Prchal-Murphy, M., Edlinger, L., Knab, V. M., Uras, I. Z., Grundschober, E., Bauer, K., Roth, M., Skucha, A., Liu, Y., Hatcher, J. M., Liang, Y., Kwiatkowski, N. P., Fux, D., Hoelbl-Kovacic, A., Kubicek, S., Melo, J. V., Valent, P., Weichhart, T., Grebien, F., Zuber, J., Gray, N. S. and Sexl, V. A kinase-independent role for CDK8 in BCR-ABL1(+) leukemia Nat Commun. 2019 Oct 18;10(1):4741. doi: 10.1038/s41467-019-12656-x |
| Kaltenecker, D., Themanns, M., Mueller, K.M., Spirk, K., Suske, T., Merkel, O., Kenner, L., LuÃs, A., Kozlov, A., Haybaeck, J., Mueller, M., Han, X. and Moriggl, R. Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression Cytokine 2019 Oct 30;124:154569. doi: 10.1016/j.cyto.2018.10.010 |
| Halbritter, F., Farlik, M., Schwentner, R., Jug, G., Fortelny, N., Schnoller, T., Pisa, H., Schuster, L. C., Reinprecht, A., Czech, T., Gojo, J., Holter, W., Minkov, M., Bauer, W. M., Simonitsch-Klupp, I., Bock, C. and Hutter, C. Epigenomics and Single-cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis Journal: Cancer Discov Cancer Discov. 2019 Jul 25. pii: 2159-8290.CD-19-0138. doi: 10.1158/2159-8290.CD-19-0138 |
| Gotthardt, D., Trifinopoulos, J., Sexl, V. and Putz, E. M. JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation Front Immunol. 2019 Nov 12;10:2590. doi: 10.3389/fimmu.2019.02590. eCollection 2019 |
| de Araujo, E. D., Orlova, A., Neubauer, H. A., Bajusz, D., Seo, H. S., Dhe-Paganon, S., Keseru, G. M., Moriggl, R. and Gunning, P. T. Structural Implications of STAT3 and STAT5 SH2 Domain Mutations Cancers (Basel). 2019 Nov 8;11(11). pii: cancers11111757. doi: 10.3390/cancers11111757 |
2018 Publications
| Crncec, I., Modak, M., Gordziel, C., Svinka, J., Scharf, I., Moritsch, S., Pathria, P., Schlederer, M., Kenner, L., Timelthaler, G., Muller, M., Strobl, B., Casanova, E., Bayer, E., Mohr, T., Stockl, J., Friedrich, K., and Eferl, R. (2018). Stat1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer. Mol Oncol 10.1002/1878-0261.12178 |
| Glasner, A., Levi, A., Enk, J., Isaacson, B., Viukov, S., Orlanski, S., Scope, A., Neuman, T., Enk, C.D., Hanna, J.H., Sexl, V., Jonjic, S., Seliger, B., Zitvogel, L., and Mandelboim, O. (2018). NKp46 Receptor-Mediated Interferon-gamma Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Immunity 10.1016/j.immuni.2017.12.007 |
| Orlova, A., Wingelhofer, B., Neubauer, H.A., Maurer, B., Berger-Becvar, A., Keseru, G.M., Gunning, P.T., Valent, P., and Moriggl, R. (2018). Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas. Expert Opin Ther Targets 22, 45-57. doi: 10.1080/14728222.2018.1406924 |
| Pham, H.T.T., Maurer, B., Prchal-Murphy, M., Grausenburger, R., Grundschober, E., Javaheri, T., Nivarthi, H., Boersma, A., Kolbe, T., Elabd, M., Halbritter, F., Pencik, J., Kazemi, Z., Grebien, F., Hengstschlager, M., Kenner, L., Kubicek, S., Farlik, M., Bock, C., Valent, P., Muller, M., Rulicke, T., Sexl, V., and Moriggl, R. (2018). STAT5BN642H is a driver mutation for T cell neoplasia. J Clin Invest 128, 387-401 |
| Schrader, A., Crispatzu, G., Oberbeck, S., Mayer, P., Putzer, S., von Jan, J., Vasyutina, E., Warner, K., Weit, N., Pflug, N., Braun, T., Andersson, E.I., Yadav, B., Riabinska, A., Maurer, B., Ventura Ferreira, M.S., Beier, F., Altmuller, J., Lanasa, M., Herling, C.D., Haferlach, T., Stilgenbauer, S., Hopfinger, G., Peifer, M., Brummendorf, T.H., Nurnberg, P., Elenitoba-Johnson, K.S.J., Zha, S., Hallek, M., Moriggl, R., Reinhardt, H.C., Stern, M.H., Mustjoki, S., Newrzela, S., Frommolt, P., and Herling, M. (2018). Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL. Nat Commun 9, 697 |
| Wingelhofer, B., Maurer, B., Heyes, E.C., Cumaraswamy, A.A., Berger-Becvar, A., de Araujo, E.D., Orlova, A., Freund, P., Ruge, F., Park, J., Tin, G., Ahmar, S., Lardeau, C.H., Sadovnik, I., Bajusz, D., Keseru, G.M., Grebien, F., Kubicek, S., Valent, P., Gunning, P.T., and Moriggl, R. (2018). Pharmacologic inhibition of STAT5 in acute myeloid leukemia. Leukemia 10.1038/s41375-017-0005-9 |
| Baumgartner, C., Toifl, S., Farlik, M., Halbritter, F., Scheicher, R., Fischer, I., Sexl, V., Bock, C. and Baccarini, M. (2018) An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion Cell Stem Cell. 2018 May 17. pii: S1934-5909(18)30221-2. doi: 10.1016/j.stem.2018.05.003 |
| Cohen, M., Giladi, A., Gorki, A. D., Solodkin, D. G., Zada, M., Hladik, A., Miklosi, A., Salame, T. M., Halpern, K. B., David, E., Itzkovitz, S., Harkany, T., Knapp, S. and Amit, I. Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting Cell. 2018 Sep 28. pii: S0092-8674(18)31181-4. doi: 10.1016/j.cell.2018.09.009 |
| Grohmann, M., Wiede, F., Dodd, G.T., Gurzov, E.N., Ooi, G.J., Butt, T., Rasmiena, A.A., Kaur, S., Gulati, T., Goh, P.K., Treloar, A.E., Archer, S., Brown, W.A., Muller, M., Watt, M.J., Ohara, O., McLean, C.A. and Tiganis, T. Obesity drives STAT-1-dependent NASH and STAT-3-dependent HCC Cell. 2018 Nov 15;175(5):1289-1306.e20. doi: 10.1016/j.cell.2018.09.053. Epub 2018 Oct 25 |
| Kaltenecker, D., Themanns, M., Mueller, K. M., Spirk, K., Golob-Schwarzl, N., Friedbichler, K., Kenner, L., Haybaeck, J. and Moriggl, R. STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice Cytokine. 2018 Oct 27. pii: S1043-4666(18)30402-2. doi: 10.1016/j.cyto.2018.10.014 |
| Kaltenecker, D., Themanns, M., Mueller, K.M., Spirk, K., Suske, T., Merkel, O., Kenner, L., LuÃs, A., Kozlov, A., Haybaeck, J., Mueller, M., Han, X. and Moriggl, R. Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression Cytokine.2018 Oct 30. doi: 10.1016/j.cyto.2018.10.010 |
| Moll, H. P., Pranz, K., Musteanu, M., Grabner, B., Hruschka, N., Mohrherr, J., Aigner, P., Stiedl, P., Brcic, L., Laszlo, V., Schramek, D., Moriggl, R., Eferl, R., Moldvay, J., Dezso, K., Lopez-Casas, P. P., Stoiber, D., Hidalgo, M., Penninger, J., Sibilia, M., Gyorffy, B., Barbacid, M., Dome, B., Popper, H. and Casanova, E. Afatinib restrains K-RAS-driven lung tumorigenesis Sci Transl Med. 2018 Jun 20;10(446). pii: 10/446/eaao2301. doi: 10.1126/scitranslmed.aao2301 |
| Parrini, M., Meissl, K., Ola, M.J., Lederer, T., Puga, A., Wienerroither, S., Kovarik, P., Decker, T., Mueller, M. and Strobl, B. The C-terminal transactivation domain of STAT1 has a gene-specific role in transactivation and cofactor recruitment Front Immunol. 2018 Dec 6;9(2879). doi: 10.3389/fimmu.2018.02879 |
| Pham, H. T. T., Hengstschlager, M. and Moriggl, R. A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia Mol Cell Oncol. 2018 Mar 28;5(3):e1435181. doi: 10.1080/23723556.2018.1435181. eCollection 2018. |
| Platanitis, E. and Decker, T. Regulatory networks involving STATs, IRFs, and NFkB in inflammation Front Immunol. 2018 Nov 13;9:2542. doi: 10.3389/fimmu.2018.02542. eCollection 2018 |
| Porpaczy, E., Tripolt, S., Hoelbl-Kovacic, A., Gisslinger, B., Bago-Horvath, Z., Casanova-Hevia, E., Clappier, E., Decker, T., Fajmann, S., Fux, D. A., Greiner, G., Gueltekin, S., Heller, G., Herkner, H., Hoermann, G., Kiladjian, J. J., Kolbe, T., Kornauth, C., Krauth, M. T., Kralovics, R., Muellauer, L., Mueller, M., Prchal-Murphy, M., Putz, E. M., Raffoux, E., Schiefer, A. I., Schmetterer, K., Schneckenleithner, C., Simonitsch-Klupp, I., Skrabs, C., Sperr, W. R., Staber, P. B., Strobl, B., Valent, P., Jaeger, U., Gisslinger, H. and Sexl, V. Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy Blood. 2018 Jun 14. pii: blood-2017-10-810739. doi: 10.1182/blood-2017-10-810739 |
| Prutsch, N., Gurnhofer, E., Suske, T., Liang, H. C., Schlederer, M., Roos, S., Wu, L. C., Simonitsch-Klupp, I., Alvarez-Hernandez, A., Kornauth, C., Leone, D. A., Svinka, J., Eferl, R., Limberger, T., Aufinger, A., Shirsath, N., Wolf, P., Hielscher, T., Aberger, F., Schmoellerl, J., Stoiber, D., Strobl, B., Jager, U., Staber, P. B., Grebien, F., Moriggl, R., Muller, M., Inghirami, G. G., Sanda, T., Look, A. T., Turner, S. D., Kenner, L. and Merkel, O. Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma Leukemia. 2018 Aug 21. pii: 10.1038/s41375-018-0239-1. doi: 10.1038/s41375-018-0239-1 |
| Sternberg, C., Gruber, W., Eberl, M., Tesanovic, S., Stadler, M., Elmer, D. P., Schlederer, M., Grund, S., Roos, S., Wolff, F., Kaur, S., Mangelberger, D., Lehrach, H., Hache, H., Wierling, C., Laimer, J., Lackner, P., Wiederstein, M., Kasper, M., Risch, A., Petzelbauer, P., Moriggl, R., Kenner, L. and Aberger, F. Synergistic Cross-Talk of Hedgehog and Interleukin-6 Signaling Drives Growth of Basal Cell Carcinoma Int J Cancer. 2018 Jul 10. doi: 10.1002/ijc.31724 |
| Szappanos, D., Tschismarov, R., Perlot, T., Westermayer, S., Fischer, K., Platanitis, E., Kallinger, F., Novatchkova, M., Lassnig, C., Mueller, M., Sexl, V., Bennett, K.L., Foong-Sobis, M., Penninger, J. and Decker, T. The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity PLoS Pathog. 2018 Nov 26;14(11):e1007397. doi: 10.1371/journal.ppat.1007397 |
| Willmann, M., Hadzijusufovic, E., Hermine, O., Dacasto, M., Marcanto, L., Bauer, K., Peter, B., Gamperl, S., Eisenwort, G., Jensen-Jarolim, E., Mueller, M., Arock, M., Vail, D.M. and Valent, P. Comparative Oncology: the Paradigmatic Example of Canine and Human Mast Cell Neoplasms Vet Comp Oncol. 2018. doi:10.1111/vco.12440 |
| Wingelhofer, B., Neubauer, H.A., Valent, P., Han, X., Constantinescu, S., Gunning, P.T., Mueller, M. and Moriggl, R. Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer Leukemia. 2018 March 27. doi:10.1038/s41375-018-0117-x |
2017 Publications
| Boidol, B., Kornauth, C., van der Kouwe, E., Prutsch, N., Kazianka, L., Gultekin, S., Hoermann, G., Mayerhoefer, M.E., Hopfinger, G., Hauswirth, A., Panny, M., Aretin, M.B., Hilgarth, B., Sperr, W.R., Valent, P., Simonitsch-Klupp, I., Moriggl, R., Merkel, O., Kenner, L., Jager, U., Kubicek, S., and Staber, P.B. (2017). First in human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia. Blood 10.1182/blood-2017-05-785683 |
| Eigner, K., Filik, Y., Mark, F., Schutz, B., Klambauer, G., Moriggl, R., Hengstschlager, M., Stangl, H., Mikula, M., and Rohrl, C. (2017). The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone. Sci Rep 7, 17498 |
| Fragiadaki, M., Lannoy, M., Themanns, M., Maurer, B., Leonhard, W.N., Peters, D.J., Moriggl, R., and Ong, A.C. (2017). STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease. Kidney Int 10.1016/j.kint.2016.10.039 |
| Freund, P., Kerenyi, M.A., Hager, M., Wagner, T., Wingelhofer, B., Pham, H.T., Elabd, M., Han, X., Valent, P., Gouilleux, F., Sexl, V., Kramer, O.H., Groner, B., and Moriggl, R. (2017). O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies. Leukemia 10.1038/leu.2017.4 |
| Friedrich, K., Dolznig, H., Han, X., and Moriggl, R. (2017). Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3. Biosci Trends 10.5582/bst.2016.01250 |
| Ghanem, S., Friedbichler, K., Boudot, C., Bourgeais, J., Gouilleux-Gruart, V., Regnier, A., Herault, O., Moriggl, R., and Gouilleux, F. (2017). STAT5A/5B-specific expansion and transformation of hematopoietic stem cells. Blood Cancer J 7, e514 |
| Kaltenecker, D., Mueller, K.M., Benedikt, P., Feiler, U., Themanns, M., Schlederer, M., Kenner, L., Schweiger, M., Haemmerle, G., and Moriggl, R. (2017). Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice. Diabetologia 60, 296-305 |
| Keller, A., Wingelhofer, B., Peter, B., Bauer, K., Berger, D., Gamperl, S., Reifinger, M., Cerny-Reiterer, S., Moriggl, R., Willmann, M., Valent, P., and Hadzijusufovic, E. (2017). The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. Vet Comp Oncol 10.1111/vco.12311 |
| Linke, M., Pham, H.T., Katholnig, K., Schnoller, T., Miller, A., Demel, F., Schutz, B., Rosner, M., Kovacic, B., Sukhbaatar, N., Niederreiter, B., Bluml, S., Kuess, P., Sexl, V., Muller, M., Mikula, M., Weckwerth, W., Haschemi, A., Susani, M., Hengstschlager, M., Gambello, M.J., and Weichhart, T. (2017). Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nat Immunol 10.1038/ni.3655 |
| Majoros, A., Platanitis, E., Kernbauer-Holzl, E., Rosebrock, F., Muller, M., and Decker, T. (2017). Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses. Front Immunol 8, 29 |
| Martins, R., and Knapp, S. (2017). Heme and hemolysis in innate immunity: adding insult to injury. Curr Opin Immunol 50, 14-20 |
| Maurer, B., Farlik, M., and Sexl, V. (2017). It is a differentiation game: STAT5 in a new role. Cell Death Differ 10.1038/cdd.2017.71, 953-954 |
| Mueller, K.M., Hartmann, K., Kaltenecker, D., Vettorazzi, S., Bauer, M., Mauser, L., Amann, S., Jall, S., Fischer, K., Esterbauer, H., Muller, T.D., Tschop, M.H., Magnes, C., Haybaeck, J., Scherer, T., Bordag, N., Tuckermann, J.P., and Moriggl, R. (2017). Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and Hfd-Induced Obesity, and Impairs the Feeding-Fasting Transition. Diabetes 66, 272-286 |
2016 Publications
| Balligand, T., Achouri, Y., Pecquet, C., Chachoua, I., Nivarthi, H., Marty, C., Vainchenker, W., Plo, I., Kralovics, R., and Constantinescu, S.N. (2016). Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin. Leukemia 10.1038/leu.2016.47 |
| Bottos, A., Gotthardt, D., Gill, J.W., Gattelli, A., Frei, A., Tzankov, A., Sexl, V., Wodnar-Filipowicz, A., and Hynes, N.E. (2016). Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nat Commun 7, 12258. |
| Bourgeais, J., Ishac, N., Medrzycki, M., Brachet-Botineau, M., Desbourdes, L., Gouilleux-Gruart, V., Pecnard, E., Rouleux-Bonnin, F., Gyan, E., Domenech, J., Mazurier, F., Moriggl, R., Bunting, K.D., Herault, O., and Gouilleux, F. (2016). Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses. Oncotarget 10.18632/oncotarget.11480 |
| Castiglia, V., Piersigilli, A., Ebner, F., Janos, M., Goldmann, O., Dambock, U., Kroger, A., Weiss, S., Knapp, S., Jamieson, A.M., Kirschning, C., Kalinke, U., Strobl, B., Muller, M., Stoiber, D., Lienenklaus, S., and Kovarik, P. (2016). Type I Interferon Signaling Prevents IL-1beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue. Cell Host Microbe 19, 375-387 |
| Chachoua, I., Pecquet, C., El-Khoury, M., Nivarthi, H., Albu, R.I., Marty, C., Gryshkova, V., Defour, J.P., Vertenoeil, G., Ngo, A., Koay, A., Raslova, H., Courtoy, P.J., Choong, M.L., Plo, I., Vainchenker, W., Kralovics, R., and Constantinescu, S.N. (2016). Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. Blood 127, 1325-1335 |
| Decker, T. (2016). Emancipation from transcriptional latency: unphosphorylated STAT5 as guardian of hematopoietic differentiation. The EMBO journal 35, 555-557 |
| Floss, D.M., Klocker, T., Schroder, J., Lamertz, L., Mrotzek, S., Strobl, B., Hermanns, H., and Scheller, J. (2016). Defining the functional binding sites of Interleukin 12 receptor beta1 and Interleukin 23 receptor to Janus kinases. Molecular biology of the cell 27, 2301-2316 |
| Gotthardt, D., Putz, E.M., Grundschober, E., Prchal-Murphy, M., Straka, E., Kudweis, P., Heller, G., Bago-Horvath, Z., Witalisz-Siepracka, A., Cumaraswamy, A.A., Gunning, P.T., Strobl, B., Muller, M., Moriggl, R., Stockmann, C., and Sexl, V. (2016). STAT5 is a key regulator in NK cells and acts as molecular switch from tumor surveillance to tumor promotion. Cancer discovery 6, 414-429 |
| Harutyunyan, A.S., Giambruno, R., Krendl, C., Stukalov, A., Klampfl, T., Berg, T., Chen, D., Milosevic Feenstra, J.D., Jager, R., Gisslinger, B., Gisslinger, H., Rumi, E., Passamonti, F., Pietra, D., Muller, A.C., Parapatics, K., Breitwieser, F.P., Herrmann, R., Colinge, J., Bennett, K.L., Superti-Furga, G., Cazzola, M., Hammond, E., and Kralovics, R. (2016). Germline RBBP6 mutations in familial myeloproliferative neoplasms. Blood 127, 362-365 |
| Javaheri, T., Kazemi, Z., Pencik, J., Pham, H.T., Kauer, M., Noorizadeh, R., Sax, B., Nivarthi, H., Schlederer, M., Maurer, B., Hofbauer, M., Aryee, D.N., Wiedner, M., Tomazou, E.M., Logan, M., Hartmann, C., Tuckermann, J.P., Kenner, L., Mikula, M., Dolznig, H., Uren, A., Richter, G.H., Grebien, F., Kovar, H., and Moriggl, R. (2016). Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation. Cell Death Dis 7, e2419 |
| Klose, R., Krzywinska, E., Castells, M., Gotthardt, D., Putz, E.M., Kantari-Mimoun, C., Chikdene, N., Meinecke, A.K., Schrodter, K., Helfrich, I., Fandrey, J., Sexl, V., and Stockmann, C. (2016). Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia. Nat Commun 7, 12528 |
| Maier, B.B., Hladik, A., Lakovits, K., Korosec, A., Martins, R., Kral, J.B., Mesteri, I., Strobl, B., Muller, M., Kalinke, U., Merad, M., and Knapp, S. (2016). Type I interferon promotes alveolar epithelial type II cell survival during pulmonary S. pneumoniae infection and sterile lung injury in mice. European journal of immunology 10.1002/eji.201546201 |
| Majoros, A., Platanitis, E., Szappanos, D., Cheoan, H.J., Vogl, C., Shukla, P., Stark, G.R., Sexl, V., Schreiber, R.D., Schindler, C., Mueller, M., and Decker, T. (2016). Response to interferons and antibacterial innate immunity in absence of tyrosine-phosphorylated STAT1. EMBO Rep 17, 367-382 |
| Marty, C., Pecquet, C., Nivarthi, H., El-Khoury, M., Chachoua, I., Tulliez, M., Villeval, J.L., Raslova, H., Kralovics, R., Constantinescu, S.N., Plo, I., and Vainchenker, W. (2016). Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis. Blood 127, 1317-1324 |
| Milosevic Feenstra, J.D., Nivarthi, H., Gisslinger, H., Leroy, E., Rumi, E., Chachoua, I., Bagienski, K., Kubesova, B., Pietra, D., Gisslinger, B., Milanesi, C., Jager, R., Chen, D., Berg, T., Schalling, M., Schuster, M., Bock, C., Constantinescu, S.N., Cazzola, M., and Kralovics, R. (2016). Whole exome sequencing identifies novel MPL and JAK2 mutations in triple negative myeloproliferative neoplasms. Blood 127, 325-332 |
| Nivarthi, H., Chen, D., Cleary, C., Kubesova, B., Jaeger, R., Bogner, E., Marty, C., Pecquet, C., Vainchenker, W., Constantinescu, S.N., and Kralovics, R. (2016). Thrombopoietin receptor is required for the oncogenic function of CALR mutants. Leukemia 10.1038/leu.2016.32 |
| Nivarthi, H., Gordziel, C., Themanns, M., Kramer, N., Eberl, M., Rabe, B., Schlederer, M., Rose-John, S., Knosel, T., Kenner, L., Freund, P., Aberger, F., Han, X., Kralovics, R., Dolznig, H., Jennek, S., Friedrich, K., and Moriggl, R. (2016). The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. Oncotarget 10.18632/oncotarget.9315 |
| Park, J., Kim, S., Joh, J., Remick, S.C., Miller, D.M., Yan, J., Kanaan, Z., Chao, J.H., Krem, M.M., Basu, S.K., Hagiwara, S., Kenner, L., Moriggl, R., Bunting, K.D., and Tse, W. (2016). MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling. Oncotarget 10.18632/oncotarget.9759 |
| Pencik, J., Pham, H.T., Schmoellerl, J., Javaheri, T., Schlederer, M., Culig, Z., Merkel, O., Moriggl, R., Grebien, F., and Kenner, L. (2016). JAK-STAT signaling in cancer: From cytokines to non-coding genome. Cytokine 10.1016/j.cyto.2016.06.017 |
| Putz, E.M., Majoros, A., Gotthart, D., Prchal-Murphy, M., Zebedin-Brandl, E., Fux, D.A., Schlattl, A., Schreiber, R.D., Carotta, S., Mueller, M., Gerner, C., Decker, T., and Sexl, V. (2016). Novel non-Âcanonical role of STAT1 in Natural Killer cell cytotoxicity. OncoImmunology 10.1080/2162402X.2016.1186314. |
| Themanns, M., Mueller, K.M., Kessler, S.M., Golob-Schwarzl, N., Mohr, T., Kaltenecker, D., Bourgeais, J., Paier-Pourani, J., Friedbichler, K., Schneller, D., Schlederer, M., Zebedin-Brandl, E., Terracciano, L.M., Han, X., Kenner, L., Wagner, K.U., Mikulits, W., Kozlov, A.V., Heim, M.H., Gouilleux, F., Haybaeck, J., and Moriggl, R. (2016). Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice. Sci Rep 6, 34719 |
| Zotz, J.S., Wölbing, F., Lassnig, C., Kauffmann, M., Schulte, U., Kolb, A., Whitelaw, B., Mueller, M., Biedermann, T., and Huber, M. (2016). CD13/aminopeptidase N is a negative regulator of mast cell activation. FASEB J 30, 2225-2235 |
2015 Publications
| Gilbert*, S., Nivarthi*, H., Mayhew*, C.N., Lo, Y.H., Noah, T.K., Vallance, J., Rulicke, T., Mueller, M., Jegga, A.G., Tang, W., Zhang, D., Helmrath, M., Shroyer, N., Moriggl, R., and Han, X. (2015). *equal contribution Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration. Stem Cell Rep 4: 209-225. doi: 10.1016/j.stemcr.2014.12.004 |
| Nivarthi, H., Prchal-Murphy, M., Swoboda, A., Hager, M., Schlederer, M., Kenner, L., Tuckermann, J., Sexl, V., Moriggl, R., and Ermakova, O. (2015). Stat5 gene dosage in T cells modulates CD8 T cell homeostasis and attenuates contact hypersensitivity response in mice. Allergy 70: 67-79. doi: 10.1111/all.12535 |
| Pathria*, P., Gotthardt*, D., Prchal-Murphy*, M., Putz*, E.M., Holcmann, M., Schlederer, M., Grabner, B., Crncec, I., Svinka, J., Musteanu, M., Hoffmann, T., Filipits, M., Berger, W., Poli, V., Kenner, L., Bilban, M., Casanova, E., Mueller, M., Strobl, B., Bayer, E., Mohr, T., Sexl, V., and Eferl§, R. (2015). *equal contribution §SFB member of the 1st and 2nd funding period Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice. Oncoimmunology 4(4):e998529. doi: 10.1080/2162402X.2014.998529 |
| Prchal-Murphy, M., Witalisz-Siepracka, A., Bednarik, K.T., Putz, E.M., Gotthardt, D., Meissl, K., Sexl, V., Mueller, M., and Strobl, B. (2015). In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity. Oncoimmunology. doi: 10.1080/2162402X.2015.1047579 |
| Rauch, I., Rosebrock, F., Hainzl, E., Heider, S., Majoros, A., Wienerroither, S., Strobl, B., Stockinger, S., Mueller, M., Kenner, L., and Decker, T. (2015). Noncanonical effects of IRF9 in intestinal inflammation: more than type I and type III interferons. Mol Cell Biol 35: 2332-2343 doi: 10.1128/MCB.01498-14 |
| Wienerroither, S., Shukla, P., Farlik, M., Majoros, A., Stych, B., Vogl, C., Cheon, H., Stark, G.R., Strobl, B., Mueller, M., and Decker, T. (2015). Cooperative transcriptional activation of antimicrobial genes by STAT and NFκB pathways through concerted recruitment of the mediator complex. Cell Reports 12: 1-13. doi: http://dx.doi.org/10.1016/j.celrep.2015.06.021 |
| Bakiri, L., Macho-Maschler, S., Custic, I., Niemiec, J., Guio-Carrion, A., Hasenfuss, S.C., Eger, A., Mueller, M., Beug†, H., and Wagner, E.F. (2015). †1945-2011, SFB member of the 1st funding period; associated with coordination project Fra-1/AP-1 induces mammary epithelial cell EMT by modulating Zeb1/2 and TGFbeta expression. Cell Death Differ 22: 336-350. doi: 10.1038/cdd.2014.157 |
| Abdul-Sater, A.A., Majoros, A., Plumlee, C.R., Perry, S., Gu, A.D., Lee, C., Shresta, S., Decker, T., and Schindler, C. (2015). Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs. J Immunol May 27. pii: 1401139. [Epub ahead of print] doi: 10.4049/jimmunol.1401139 |
| Pencik, J., Schlederer, M., Gruber, W., Unger, C., Walker, S.M., Chalaris, A., Marié, I.J., Hassler, M.R., Javaheri, T., Aksoy, O., Blayney, J.K., Prutsch, N., Skucha, A., Herac, M., Krämer, O.H., Mazal, P., Grebien, F., Egger, G., Poli, V., Mikulits§, W., Eferl§, R., Esterbauer, H., Kennedy, R., Fend, F., Scharpf, M., Braun, M., Perner, S., Levy, D.E., Malcolm, T., Turner, S.D., Haitel, A., Susani, M., Moazzami, A., Rose-John, S., Aberger, F., Merkel, O., Moriggl, R., Culig, Z., Dolznig, H., and Kenner, L. (2015). §SFB member of the 1st and 2nd funding period STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun. 6:7736. doi: 10.1038/ncomms8736 |
| Schutz, A., Roser, K., Klitzsch, J., Lieder, F., Aberger, F., Gruber, W., Mueller, K.M., Pupyshev, A., Moriggl, R., and Friedrich, K. (2015). Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation. Transl Oncol 8: 97-105. doi: dx.doi.org/10.1016/j.tranon.2015.02.002 |
| Girardot, M., Pecquet, C., Chachoua, I., Van Hees, J., Guibert, S., Ferrant, A., Knoops, L., Baxter, E.J., Beer, P.A., Giraudier, S., Moriggl, R., Vainchenker, W., Green, A.R., and Constantinescu, S.N. (2015). Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene 34:1323-1332. doi: 10.1038/onc.2014.60 |
| Merkel, O., Hamacher, F., Griessl, R., Grabner, L., Schiefer, A.I., Prutsch, N., Baer, C., Egger, G., Schlederer, M., William Krenn, P., Nicole Hartmann, T., Simonitsch-Klupp, I., Plass, C., Staber, P., Moriggl, R., Turner, S.D., Greil, R., and Kenner, L. (2015). Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation. J Pathol Mar 26. [Epub ahead of print] doi: 10.1002/path.4539 |
| Park, J., Schlederer, M., Schreiber, M., Ice, R., Merkel, O., Bilban, M., Hofbauer, S., Kim, S., Addison, J., Zou, J., Ji, C., Bunting, S.T., Wang, Z., Shoham, M., Huang, G., Bago-Horvath, Z., Gibson, L.F., Rojanasakul, Y., Remick, S., Ivanov, A., Pugacheva, E., Bunting, K.D., Moriggl, R., Kenner, L., and Tse, W. (2015). AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. Oncotarget. Online ISSN: 1949-2553 |
| Stiedl, P., McMahon, R., Blaas, L., Stanek, V., Svinka, J., Grabner, B., Zollner, G., Kessler, S.M., Claudel, T., Mueller, M., Mikulits§, W., Bilban, M., Esterbauer, H., Eferl§, R., Haybaeck, J., Trauner, M., and Casanova, E. (2015). §SFB member of the 1st and 2nd funding period Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology 61: 613-626. doi: 10.1002/hep.27408 |
| Ustun, S., Lassnig, C., Preitschopf, A., Mikula, M., Mueller, M., Hengstschlager, M., and Weichhart, T. (2015). Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transplant immunology. [Epub ahead of print] doi: 10.1016/j.trim.2015.06.001 |
| Schneckenleithner, C., Hoelbl-Kovacic, A., and Sexl, V. (2015). Modeling BCR/ABL-Driven Malignancies in the Mouse. Methods in Mol Biol 1267: 263-282. [review] doi: 10.1007/978-1-4939-2297-0_12 |
| Wiesauer, I., Gaumannmuller, C., Steinparzer, I., Strobl, B., and Kovarik§, P. (2015). §SFB member of the 1st funding period Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription. Mol Cell Biol 35: 716-727. doi: 10.1128/MCB.01097-14 |
| Bauer, E., Witalisz, A., Strobl, B., and Stoiber, D. (2015). Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice. Methods Mol Biol 1267: 439-456. [review] doi: 10.1007/978-1-4939-2297-0_22 |
| Them, N.C., Bagienski, K., Berg, T., Gisslinger, B., Schalling, M., Chen, D., Buxhofer-Ausch, V., Thaler, J., Schloegl, E., Gastl, G.A., Wolf, D., Strecker, K., Egle, A., Melchardt, T., Burgstaller, S., Willenbacher, E., Zagrijtschuk, O., Klade, C., Greil, R., Gisslinger, H., and Kralovics, R. (2015). Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b. Am J Hematol 90: 288-294 doi: 10.1002/ajh.23928 |
| Berry, D., Kuzyk, O., Rauch, I., Heider, S., Schwab, C., Hainzl, E., Decker, T., Mueller, M., Strobl, B., Schleper, C., Urich, T., Wagner, M., Kenner, L., and Loy, A. (2015). Intestinal microbiota signatures associated with inflammation history in mice experiencing recurring colitis Front Microbiol. 2015; 6: 1408. doi: 10.3389/fmicb.2015.01408 |
| Hainzl, E., Stockinger, S., Rauch, I., Heider, S., Berry, D., Lassnig, C., Schwab, C., Rosebrock, F., Milinovich, G., Schlederer, M., Wagner, M., Schleper, C., Loy, A., Urich, T., Kenner, L., Han, X., Decker, T., Strobl, B., and Muller, M. (2015). Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis. Journal of immunology 195, 5011-5024. Journal of immunology 195, 5011-5024 |
| Leitner, N.R., Witalisz-Siepracka, A., Strobl, B., and Muller, M. (2015). Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene. Cytokine 10.1016/j.cyto.2015.10.015 |
| Leopold Wager, C.M., Hole, C.R., Wozniak, K.L., Olszewski, M.A., Mueller, M., and Wormley, F.L., Jr. (2015). STAT1 Signaling within Macrophages is Required for Anti-fungal Activity against Cryptococcus neoformans. . Infection and immunity 10.1128/IAI.00935-15. |
| Minas, T.Z., Han, J., Javaheri, T., Hong, S.H., Schlederer, M., Saygideger-Kont, Y., Celik, H., Mueller, K.M., Temel, I., Ozdemirli, M., Kovar, H., Erkizan, H.V., Toretsky, J., Kenner, L., Moriggl, R., and Uren, A. (2015). YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. Oncotarget 6, 37678-37694 |
| Shukla, P., Vogl, C., Wallner, B., Rigler, D., Mueller, M., and Macho-Maschler, S. (2015). High-Throughput mRNA and miRNA Profiling of Epithelial-Mesenchymal Transition in MDCK cells. BMC Genomics 16, 944 |
2014 Publications
| Berger*, A., Hoelbl-Kovacic*, A., Bourgeais, J., Hoefling, L., Warsch, W., Grundschober, E., Uras, I.Z., Menzl, I., Putz, E.M., Hoermann, G., Schuster, C., Fajmann, S., Leitner, E., Kubicek, S., Moriggl, R., Gouilleux, F., and Sexl, V. (2014). *equal contribution PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28: 629-641. doi: 10.1038/leu.2013.351 |
| Berger, A., Sexl, V., Valent, P., and Moriggl, R. (2014). Inhibition of STAT5: A therapeutic option in BCR-ABL1-driven leukemia. Oncotarget 5: 9564-9576. Online ISSN: 1949-2553 |
| Bosmann, M., Russkamp, N.F., Strobl, B., Roewe, J., Balouzian, L., Pache, F., Radsak, M.P., van Rooijen, N., Zetoune, F.S., Sarma, J.V., Núnez, G., Mueller, M., Murray, P.J., and Ward, P.A. (2014). Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. J Immunol 193: 5668-5677. doi: 10.4049/jimmunol.1302280 |
| Bosmann, M., Strobl, B., Kichler, N., Pache, F., Murray, P.J., Mueller, M., and Ward, P.A. (2014). Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol. 96: 123-131. doi: 10.1189/jlb.3A1013-541R |
| Gotthardt, D., Putz, E.M., Straka, E., Kudweis, P., Biaggio, M., Poli, V., Strobl, B., Mueller, M., and Sexl, V. (2014). Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance. Blood 124: 2370-2379. doi: http://dx.doi.org/10.1182/blood-2014-03-564450 |
| Grunert, T., Monahan, A., Lassnig, C., Vogl, C., Strobl, B., Mueller, M., and Ehling-Schulz, M. (2014). Deciphering host genotype-specific impacts on the metabolic fingerprint of Listeria monocytogenes by FTIR spectroscopy. PLoS One 9: e115959. doi: 10.1371/journal.pone.0115959 |
| Keil, E., Finkenstädt, D., Wufka, C., Trilling, M., Liebfried, P., Strobl, B., Mueller, M., and Pfeffer, K. (2014). Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation loop mutation. Blood 123: 520-529. doi: http://dx.doi.org/10.1182/blood-2013-03-492157 |
| Kovacic, B., Hoelbl-Kovacic, A., Fischhuber, K.M., Leitner, N.R., Gotthardt, D., Casanova, E., Sexl, V., and Mueller, M. (2014). Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells. Haematologica 99: 1006-1015. doi: 10.3324/haematol.2013.097154 |
| Leitner, N.R., Lassnig, C., Rom, R., Heider, S., Bago-Horvath, Z., Eferl§, R., Mueller, S., Kolbe, T., Kenner, L., Ruelicke, T., Strobl, B., and Mueller, M. (2014). §SFB member of the 1st and 2nd funding period Inducible, dose-adjustable and time-restricted reconstitution of Stat1 deficiency in vivo. PLoS One 9: e86608. doi: 10.1371/journal.pone.0086608 |
| Liehl, P., Zuzarte-LuÃs, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K.K., Carret, C., Lassnig, C., Mueller, M., Kalinke, U., Saeed, M., Ferreira Chora, A., Golenbock, D.T., Strobl, B., Prudencio, M., Coelho, L.P., Kappe, S.H., Superti-Furga, J., Pichlmair, A., Vigário, A.M., Rice, C.M., Fitzgerald, K.A., Barchert, W., and Mota, M.M. (2014). Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 20: 47-53. doi: 10.1038/nm.342 |
| Semper, C., Leitner, N.R., Lassnig, C., Parrini, M., Mahlakoiv, T., Rammerstorfer, M., Lorenz, K., Rigler, D., Mueller, S., Kolbe, T., Vogl, C., Ruelicke, T., Staeheli, P., Decker, T., Mueller, M., and Strobl, B. (2014). STAT1β is not dominant negative and is capable of contributing to IFNγ-dependent innate immunity. Mol Cell Biol 34: 2235-2248. doi: 10.1128/MCB.00295-14 |
| Vielnascher, R.M., Hainzl, E., Leitner, N.R., Rammerstorfer, M., Popp, D., Witalisz, A., Rom, R., Karaghiosoff, M., Kolbe, T., Mueller, S., Ruelicke, T., Lassnig, C., Strobl, B., and Mueller, M. (2014). Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance. Transgenic Res. 23: 519-529. doi: 10.1007/s11248-014-9795-y |
| Wienerroither, S., Rauch, I., Rosebrock, F., Jamieson, A.M., Bradner, J., Muhar, M., Zuber, J., Mueller, M., and Decker, T. (2014). Regulation of NO synthesis, local inflammation and innate immunity to pathogens by BET family proteins. Mol Cell Biol 34: 415-427. doi: 10.1128/MCB.01353-13 |
| Strobl, B., and Moriggl, R. (2014). Editorial: Recovery from chemotherapy depends on STAT1 for replenishment of B lymphopoiesis. J Leukocyte Biol 95: 849-851. [editorial review] doi: 10.1189/jlb.0114051 |
| Csiszar, A., Kutay, B., Wirth, S., Schmidt, U., Macho-Maschler, S., Schreiber, M., Alacakaptan, M., Vogel, G.F., Aumayr, K., Huber, L.A., and Beug, H.†(2014). †1945-2011, SFB member of the 1st funding period; associated with coordination project Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen inverted question mark urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression. Breast Cancer Res 16: 433. doi: 10.1186/s13058-014-0433-7 |
| Begitt, A., Droescher, M., Meyer, T., Schmid, C.D., Baker, M., Antunes, F., Owen, M.R., Naumann, R., Decker, T., and Vinkemeier, U. (2014). STAT1-cooperative DNA binding distinguishes type-1 from type-2 interferon signaling. Nat Immunol 15: 168-176. doi: 10.1038/ni.2794 |
| Schlederer, M., Mueller, K.M., Haybaeck, J., Heider, S., Huttary, N., Rosner, M., Hengstschlager, M., Moriggl, R., Dolznig, H., and Kenner, L. (2014). Reliable Quantification of Protein Expression and Cellular Localization in Histological Sections. PLoS One 9: e100822. doi: 10.1371/journal.pone.0100822 |
| Bibi, S., Arslanhan, M.D., Langenfeld, F., Jeanningros, S., Cerny-Reiterer, S., Hadzijusufovic, E., Tchertanov, L., Moriggl, R., Valent, P., and Arock, M. (2014). Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy. Haematologica 99: 417-429. [review] doi: 10.3324/haematol.2013.098442 |
| Gotthardt, D., Prchal-Murphy, M., Seillet, C., Glasner, A., Mandelboim, O., Carotta, S., Sexl, V., and Putz, E.M. (2014). NK cell development in bone marrow and liver: site matters. Genes Immun 15: 584-587. doi: 10.1038/gene.2014.55 |
| Grundschober, E., Hoelbl-Kovacic, A., Bhagwat, N., Kovacic, B., Scheicher, R., Eckelhart, E., Kollmann, K., Keller, M., Grebien, F., Wagner, K.U., Levine, R.L., and Sexl, V. (2014). Acceleration of Bcr-Abl leukemia induced by deletion of JAK2. Leukemia 28: 1918-1922. doi: 10.1038/leu.2014.152 |
| Putz, E.M., Hoelzl, M.A., Baeck, J., Bago-Horvath, Z., Schuster, C., Reichholf, B., Kern, D., Aberger, F., Sexl, V., and Hoelbl-Kovacic, A. (2014). Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance. Cancers 6: 193-210. doi: 10.3390/cancers6010193 |
| Klose, C.S., Flach, M., Mohle, L., Rogell, L., Hoyler, T., Ebert, K., Fabiunke, C., Pfeifer, D., Sexl, V., Fonseca-Pereira, D., Domingues, R.G., Veiga-Fernandes, H., Arnold, S.J., Busslinger, M., Dunay, I.R., Tanriver, Y., and Diefenbach, A. (2014). Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages. Cell 157: 340-356. |
| Jager, R., Harutyunyan, A.S., Rumi, E., Pietra, D., Berg, T., Olcaydu, D., Houlston, R.S., Cazzola, M., and Kralovics, R. (2014). Common germline variation at the TERT locus contributes to familial clustering of myeloproliferative neoplasms. Am J Hematol 89: 1107-1110. doi: 10.1002/ajh.23842 |
2013 Publications
| Rauch, I., Mueller, M., and Decker, T. (2013). The regulation of inflammation by interferons and their STATs. JAK-STAT 2:1, e23820. [review] doi: 10.4161/jkst.23820 |
| Kernbauer*, E., Maier*, V., Rauch, I., Mueller, M. and Decker, T. (2013). *equal contribution Route of infection determines the impact of type I interferons on innate immunity to Listeria monocytogenes. PLoS One 8: e65007. doi: 10.1371/journal.pone.0065007 |
| Kollmann, K., Heller, G., Schneckenleitner, C., Warsch, W., Scheicher, R., Ott, R.G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Mueller, S., Kerjaschki, D., Bock, C., LKenner, L., Hoefler, G., Freissmuth, M., Green, A.R., Moriggl, R., Busslinger, M., Malumbres, M., and Sexl, V. (2013). A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis. Cancer Cell 24: 167-181. doi: dx.doi.org/10.1016/j.ccr.2013.07.012 |
| Köpruelue, A.D., Kastner, R., Wienerroither, S., Lassnig, C., Putz, E.-M., Majer, O., Reutterer, B., Sexl, V., Kuchler, K., Mueller, M., Decker, T., and Ellmeier, W. (2013). The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. PLoS One 8: e60476. doi: 10.1371/journal.pone.0060476 |
| Putz, E.M., Gotthardt, D., Hoermann, G., Csiszar, A., Wirth, S., Berger, A., Straka, E., Rigler, D., Wallner, B., Jamieson, A.M., Pickl, W.F., Zebedin-Brandl, E.M., Mueller, M., Decker, T., and Sexl, V. (2013). CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance. Cell Rep 15: 437-444. doi: 10.1016/j.celrep.2013.07.012 |
| Sanda, T., Tyner, J.W., Gutierrez, A., Ngo, V.N., Glover, J., Chang, B.H., Yost, A., Ma, W., Fleischman, A.G., Zhou, W., Yang, Y., Kleppe, M., Ahn, Y., Tatarek, J., Kelliher, M., Neuberg, D., Levine, R.L., Moriggl, R., Mueller, M., Gray, N.S., Jamieson, C.H., Weng, A.P., Staudt, L.M., Druker, B.J., and Look, A.T. (2013). TYK2-STAT1-BCL2 Pathway Dependence in T-Cell Acute Lymphoblastic Leukemia. Cancer Discov 3: 564-577. doi: 10.1158/2159-8290.CD-12-0504 |
| Warszawska, J.M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., Fuhrmann, V., Strobl, B., Mueller, M., Schenk, P., Weiss, G., and Knapp, S. (2013). Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest 123: 3363-3372. doi: 10.1172/JCI67911 |
| Bancerek, J., Poss, Z.C., Steinparzer, I., Sedlyarov, V., Pfaffenwimmer, T., Mikulic, I., Dölken, L., Strobl, B., Mueller, M., Taatjes, D.J., and Kovarik§, P. (2013). §SFB member of the 1st funding period CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity 38: 250-262. doi: 10.1016/j.immuni.2012.10.017 |
| Chatain, N., Ziegler, P., Fahrenkamp, D., Jost, E., Moriggl, R., Schmitz-Van de Leur, H., and Mueller-Newen, G. (2013). Scr family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene 32: 3587-3597. doi: 10.1038/onc.2012.369 |
| Gordziel, C., Bratsch, J., Moriggl, R., Knosel, T. and Friedrich. K. (2013). Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. Br J Cancer 109: 138-146. doi: 10.1038/bjc.2013.274 |
| McGuckin, C.P., Jurga, M., Miller, A.M., Sarnowska, A., Wiedner, M., Boyle, N.T., Lynch, M.A., Jablonska, A., Drela, K., Lukomska, B., Domanska-Janik, K., Kenner, L., Moriggl, R., Degoul, O., Perruisseau-Carrier, C., and Forraz, N. (2013). Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction. Arch Biochem Biophys. 534: 88-97. doi: 10.1016/j.abb.2013.02.005 |
| Katholnig, K., Kaltenecker, C.C., Hayakawa, H., Rosner, M., Lassnig, C., Zlabinger, G.J., Gaesetl, M., Mueller, M., Hengstschläger, M., Hörl, W.H., Park, J.-M., Säemann, M.D., and Weichart, T. (2013). p38α Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin. J Immunol 190: 1519-1527. doi: 10.4049/jimmunol.1202683 |
| Hannesdottir, L., Tymoszuk, P., Parajuli, N., Wasmer, M.H., Philipp, S., Daschil, N., Datta, S., Koller, J.B., Tripp, C.H., Stoitzner, P., Muller-Holzner, E., Wiegers, G.J., Sexl, V., Villunger, A., and Doppler, W. (2013). Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur J Immunol. 43: 2718-2729. doi: 10.1002/eji.201242505 |
| Kantner*, H.P., Warsch*, W., Delogu, A., Bauer, E., Esterbauer, H., Casanova, E., Sexl, V., and Stoiber, D. (2013). *equal contribution ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells. Neoplasia 15: 1292-1300. doi: 10.1593/neo.131310 |
| Richter, K., Perriard, G., Behrendt, R., Schwendener, R.A., Sexl, V., Dunn, R., Kamanaka, M., Flavell, R.A., Roers, A., and Oxenius, A. (2013). Macrophage and T cell produced IL-10 promotes vrial chronicity. PLoS Pathog 9: e1003735. doi: 10.1371/journal.ppat.1003735 |
| Warsch, W., Grundschober, E., and Sexl, V. (2013). Adding a new facet to STAT5 in CML: Multitasking for leukemic cells. Cell Cycle 12: 1813-1814. [editorial feature] doi: 10.4161/cc.25116 |
| Warsch, W., Walz, C., and Sexl, V. (2013). JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia. Blood 122: 2167-2175. doi: dx.doi.org/10.1182/blood-2013-02-485573 |
| Koromilas, A.E., and Sexl, V. (2013). The tumor suppressor function of STAT1 in breast cancer. JAK-STAT 2:2, 1-5. [review] doi: 10.4161/jkst.23353 |
2012 Publications
| Laimer, D., Dolznig, H., Kollmann, K., Vesely, P.W., Schlederer, M., Merkel, O., Schiefer, A.-I., Hassler, M.R., Heider, S., Amenitsch, L., Thallinger, C., Staber, P.B., Simonitsch-Klupp, I., Artaker, M., Lagger, S., Pileri, S., Piccaluga, P.P., Valent, P., Messana, K., Landra, I., Weichhart, T., Knapp, S., Shehata, M., Todaro, M., Sexl, V., Höfler, G., Piva, R., Medico, E., Riggeri, B.A., Cheng, M., Eferl, R., Egger, G., Penninger, J.M., Jaeger, U., Moriggl, R., Inghirami, G., and Kenner, L. (2012). PDGFR blockade is a rational and effective therapy for NPM-ALK–driven lymphomas. Nat Med 18: 1699-1704. doi: 10.1038/nm.2966 |
| Putz*, E.M., Prchal-Murphy*, M., Simma, O.A., Forster, F., Koenig, X., Stockinger, H., Piekorz, R.P., Freissmuth, M., Mueller, M., Sexl, V., and Zebedin-Brandl, E. (2012). *equal contribution PI3Kδ Is Essential for Tumor Clearance Mediated by Cytotoxic T Lymphocytes. PLoS One 7: e40852. doi: 10.1371/journal.pone.0040852 |
| Warsch, W., Grundschober, E., Berger, A., Gille, L., Cerny-Reiterer, S., Tigan, A.-S., Hoelbl-Kovacic, A., Valent, P., Moriggl, R., and Sexl, V. (2012). STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia. Oncotarget 3: 1669-1687. online ISSN: 1949-2553 |
| Friedbichler, K., Themanns, M., Mueller, K.M., Schlederer, M., Kornfeld, J.-W., Terracciano, L.M., Kozlov, A.V., Haindl, S., Kenner, L., Kolbe, T., Mueller, M., Snibson, K., Heim, M.H., and Moriggl, R. (2012). Growth hormone-induced STAT5 signaling causes gigantism, inflammation and premature death but protects mice from aggressive liver cancer. Hepatology 55: 941-952. doi: 10.1002/hep.24765 |
| Kernbauer, E., Maier, V., Stoiber, D., Strobl, B., Schneckenleithner, C., Sexl, V., Reichart, U., Kalinke, U., Reizis, B., Jamieson, A., Mueller, M., and Decker, T. (2012). Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog 8: e1002763. doi: 10.1371/journal.ppat.1002763 |
| Kovacic, B., Hoelbl, A., Litos, G., Alacakaptan, M., Schuster, C., Fischhuber, K.M., Kerenyi, M.A., Stengl, G., Moriggl, R., Sexl, V., and Beug†, H. (2012). †1945-2011, SFB member of the 1st funding period; associated with coordination project Diverging fates of cells of origin in acute and chronic leukaemia. EMBO Mol Med 4: 283-297. doi: 10.1002/emmm.201100208 |
| Mizutani*, T., Neugebauer*, N., Putz*, E.M., Moritz, N., Simma, O., Zebedin-Brandl, E., Gotthardt, D., Warsch, W., Eckelhart, E., Kantner, H.-P., Kalinke, U., Lienenklaus, S., Weiss, S., Strobl, B., Mueller, M., Sexl, V., and Stoiber, D. (2012). *equal contribution Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology 1: 1027-1037. doi: 10.4161/onci.21284 |
| Musteanu, M., Blaas, L., Zenz, R., Svinka, J., Hoffmann, T., Grabner, B., Schramek, D., Kantner, H.P., Mueller, M., Kolbe, T., Ruelicke, T., Moriggl, R., Kenner, L., Stoiber, D., Penninger, J., Popper, H., Casanova, E., and Eferl, R. (2012). A mouse model to identify cooperating signaling pathways in cancer. Nat Methods 9: 897-900. doi: 10.1038/nmeth.2130 |
| Prchal-Murphy, M., Semper, C., Lassnig, C., Wallner, B., Gausterer, C., Teppner-Klymiuk, I., Kobolak, J., Mueller, S., Kolbe, T., Karaghiosoff, M., Dinnyes, A., Ruelicke, T., Leitner, N.R., Strobl, B., and Mueller, M. (2012). TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo. PLoS One 7: e39141. doi: 10.1371/journal.pone.0039141 |
| Wallner*, B., Leitner*, N.R., Vielnascher, R.M., Kernbauer, E., Kolbe, T., Karaghiosoff, M., Ruelicke, T., Decker, T., and Mueller, M. (2012). *equal contribution Generation of mice with a conditional Stat1 null allele. Transgenic Res 21: 217-224. doi: 10.1007/s11248-011-9519-5 |
| Decker, T., and Mueller, M. (2012). Jak-Stat Signaling: From Basics to Disease. Jak-Stat Signaling: From Basics to Disease. Springer Wien Heidelberg New York Dordrecht London. 448 p. 45 illus. [book] doi: 10.1007/978-3-7091-0891-8_1 ISBN: 978-3-7091-0890-1 |
| Decker, T., and Mueller, M. (2012) The Continuing Fascination with Jaks and Stats: An Introduction. Jak-Stat Signaling: From Basics to Disease. Springer Wien Heidelberg New York Dordrecht London. pp. 1-4. [book chapter] doi: 10.1007/978-3-7091-0891-8_1 |
| Vogl, C., Shukla, P., and Ebersberger, I. (2012). Evolution of Jak and Stat Proteins. Jak-Stat Signaling: From Basics to Disease. Springer Wien Heidelberg New York Dordrecht London. pp. 99-114. [book chapter] doi: 10.1007/978-3-7091-0891-8_1 |
| Allegra, M., Zaragkoulias, A., Vorgia, E., Ioannou, M., Litos, G., Beug†, H., and Mavrothalassitis, G. (2012). †1945-2011, SFB member of the 1st funding period; associated with coordination project Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells. Mol Biol Cell 23: 3873-3881. doi: 10.1091/mbc.E12-04-0276 |
| Rohr-Udilova, N., Sieghart, W., Eferl, R., Stoiber, D., Bjorkhem-Bergman, L., L, C.E., Stolze, K., Hayden, H., Keppler, B., Sagmeister, S., Grasl-Kraupp, B., Schulte-Hermann, R., and Peck-Radosavljevic, M. (2012). Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma. Hepatology 55: 1112-1121. doi: 10.1002/hep.24808 |
| Rampetsreiter, P. and Eferl, R. (2012). STAT1 and STAT3 Transcription Factors in Inflammation-Associated Colon Cancer. In Jak-Stat Signaling: From Basics to Disease. (Decker, T. and Mueller, M. Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 289-304. [book chapter] doi: 10.1007/978-3-7091-0891-8_16 ISBN: 978-3-7091-0890-1 |
| Petz, M., Them, N.C., Huber, H., and Mikulits, W. (2012). PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition. Nucleic Acids Res 40: 9738-9749. doi: 10.1093/nar/gks760 |
| Petz, M., Them, N., Huber, H., Beug†, H., and Mikulits, W. (2012). †1945-2011, SFB member of the 1st funding period; associated with coordination project La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition. Nucleic Acids Res 40: 290-302. doi: 10.1093/nar/gkr717 |
| Aubry*, C., Corr*, S.C., Wienerroither*, S., Goulard, C., Jones, R., Jamieson, A.M., Decker, T., O'Neill, L.A., Dussurget, O., and Cossart, P. (2012). *equal contribution Both TLR2 and TRIF Contribute to Interferon-beta Production during Listeria Infection. PLoS One 7: e33299. doi: 10.1371/journal.pone.0033299 |
| Aubry*, C., Corrd*, S., Wienerroither*, S., Goulard, C., Jones, R., Jamieson, A., Decker, T., O'Neill, T., Dussurget, O. and P. Cossart (2012). *equal contribution A TLR2, TLR3 and TRIF-dependent interferon-β response to bacterial infection. PLoS One 7: e33299. doi: 10.1371/journal.pone.0033299 |
| Farlik, M., Rapp, B., Marie, I., Levy, D.E., Jamieson, A.M., and Decker, T. (2012). Contribution of a TBK1-IRF7 pathway to IFN-gamma-induced gene expression. Mol Cell Biol 32: 1032-1043 doi: 10.1128/MCB.06021-11 |
| Jamieson, A., Farlik, M., and Decker, T. (2012). How Stats Interact with the Molecular Machinery of Transcriptional Activation. In Jak-Stat Signaling: From Basics to Disease. (Decker, T. and Mueller, M., Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 65-90. [book chapter] doi: 10.1007/978-3-7091-0891-8_5 ISBN: 978-3-7091-0890-1 |
| Gilbert, S., Zhang, R., Denson, L., Moriggl, R., Steinbrecher, K., Shroyer, N., Lin, J., and Han, X. (2012). Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation. EMBO Mol Med 4: 109-124. doi: 10.1002/emmm.201100192 |
| Nivarthi, H., Friedbichler, K., and Moriggl, R. (2012). Stat5 as a Hematopoietic Master Regulator for Differentiation and Neoplasia Development. In Jak-Stat Signaling: From Basics to Disease. (Decker, T. and Mueller, M., Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 153-168. [book chapter] doi: 10.1007/978-3-7091-0891-8_10 ISBN: 978-3-7091-0890-1 |
| Mueller, K.M., Themanns, M., Friedbichler, K., Kornfeld, J.W., Esterbauer, H., Tuckermann, J.P., and Moriggl, R. (2012). Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol 361: 1-11. [review] doi: 10.1016/j.mce.2012.03.026 |
| Derecka, M., Gornicka, A., Koralov, S.B., Szczepanek, K., Morgan, M., Raje, V., Sisler, J., Zhang, Q., Otero, D., Cichy, J., Rajewsky, K., Shimoda, K., Poli, V., Strobl, B., Pellegini, S., Harris, T.E., Seale, P., Russell, A.P., McAinch, A.J., O'Brien, P.E., Keller, S., Croniger, C.M., Kordula, T., and Larner, A.C. (2012). Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity. Cell Metab 16: 814-824. doi: 10.1016/j.cmet.2012.11.005 |
| Majer, O., Bourgeois, C., Zwolanek, F., Lassnig, C., Kerjaschiki, D., Mack, M., Mueller, M., and Kuchler, K. (2012). Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections. PLoS Pathog 8: e1002811. doi: 10.1371/journal.ppat.1002811 |
| Strobl, B., Leitner, N.R., and Mueller, M. (2012). Multifaceted Antiviral Actions of Interferon-Stimulated Gene Products. In Jak-Stat Signaling: From Basics to Disease. (Decker, T. and Mueller, M., Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 387-424. [book chapter] doi: 10.1007/978-3-7091-0891-8_21 ISBN: 978-3-7091-0890-1 |
| Hantschel*, O., Warsch*, W., Eckelhart, E., Kaupe, I., Grebien, F., Wagner, K.U., Superti-Furga, G., and Sexl, V. (2012). *equal contribution BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol 8: 285-293. doi: 10.1038/nchembio.775 |
| Putz, E.M., Zebedin, E., and Sexl, V. (2012). STAT Transcription Factors: Controlling All Aspects of NK Cell Biology. In Jak-Stat Signaling: From Basics to Disease (Decker, T. and Mueller, M., Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 187-204. [book chapter] doi: 10.1007/978-3-7091-0891-8_12 ISBN: 978-3-7091-0890-1 |
2011 Publications
| Bourgeois, C., Majer, O., Frohner, I.E., Lesiak-Markowicz, I., Hildering, K.S., Glaser, W., Stockinger, S., Decker, T., Akira, S., Mueller, M., and Kuchler, K. (2011). Conventional dendritic cells mount a type I interferone response against Candida spp requiring novel phagosomal TLR7 mediated IFN-β signaling. J Immunol 186, 3104-3112. doi: 10.4049/jimmunol.1002599 |
| Eckelhart, E., Warsch, W., Zebedin, E., Simma, O., Stoiber, D., Kolbe, T., Rulicke, T., Mueller, M., Casanova, E., and Sexl, V. (2011). A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK cell survival and development. Blood 117: 1565-1573. doi: dx.doi.org/10.1182/blood-2010-06-291633 |
| Kornfeld, J.W., Isaacs, A., Vitart, V., Pospisilik, J.A., Meitinger, T., Gyllensten, U., Wilson, J.F., Rudan, I., Campbell, H., Penninger, J.M., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, P.P., and Hicks, A.A. (2011). Variants in STAT5B Associate with Serum TC and LDL-C Levels. J Clin Endocrinol Metab. 96: E1496-501. doi: dx.doi.org/10.1210/jc.2011-0322 |
| Mueller, K.M., Kornfeld, J.W., Friedbichler, K., Blaas, L., Egger, G., Esterbauer, H., Hasselblatt, P., Schlederer, M., Haindl, S., Wagner, K.U., Engblom, D., Haemmerle, G., Kratky, D., Sexl, V., Kenner, L., Kozlov, A.V., Terracciano, L., Zechner, R., Schuetz, G., Casanova, E., Pospisilik, J.A., Heim, M.H., and Moriggl, R. (2011). Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology 54: 1398-1409. doi: 10.1002/hep.24509 |
| Schneckenleithner, C., Bago-Horvath, Z., Dolznig, H., Neugebauer, N., Kollmann, K., Kolbe, T., Decker, T., Kerjaschki, D., Wagner, K.-U., Mueller, M., Stoiber, D., and Sexl, V. (2011). Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias. Oncotarget 2: 1043-1054. online ISSN: 1949-2553 |
| Schneller*, D., Machat*, G., Sousek*, A., Proell, V., van Zijl, F., Zulehner, G., Huber, H., Mair, M., Muellner, M.K., Nijman, S.M., Eferl, R., Moriggl, R., and Mikulits, W. (2011). *equal contribution p19(ARF) /p14(ARF) controls oncogenic functions of Stat3 in hepatocellular carcinoma. Hepatology 54: 164-172. doi: 10.1002/hep.24329 |
| Schuster*, C., Berger*, A., Hoelzl, M.A., Putz, E.M., Frenzel, A., Simma, O., Moritz, N., Hoelbl, A., Kovacic, B., Freissmuth, M., Mueller, M., Villunger, A., Mullauer, L., Schmatz, A.I., Streubel, B., Porpaczy, E., Jager, U., Stoiber, D., and Sexl, V. (2011). *equal contribution The cooperating mutation or "second hit" determines the immunological visibility towards MYC-induced murine lymphomas. Blood 118: 4635-4645. doi: http://dx.doi.org/10.1182/blood-2010-10-313098 |
| Warsch, W., Kollmann, K., Eckelhart, E., Fajmann, S., Cerny-Reiterer, S., Holbl, A., Gleixner, K.V., Dworzak, M., Mayerhofer, M., Hoermann, G., Herrmann, H., Sillaber, C., Egger, G., Valent, P., Moriggl, R., and Sexl, V. (2011). High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia. Blood 117: 3409-3420. doi: http://dx.doi.org/10.1182/blood-2009-10-248211 |
| Friedbichler, K., Hoelbl, A., Li, G., Bunting, K.D., Sexl, V., Gouilleux, F., and Moriggl, R. (2011). Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation. Front Biosci 17: 3043-3056. [review] doi: http://dx.doi.org/10.2741/3897 |
| Strobl, B., Stoiber, D., Sexl, V., and Mueller, M. (2011). Tyrosine kinase 2 (Tyk2) in cytokine signalling and host immunity. Front Biosci 17: 3224-3232. [review] doi: http://dx.doi.org/10.2741/3908 |
| Gratz, N., Hartweger, H., Matt, U., Kratochwill, F., Janos, M., Sigel, S., Drobits, B., Li, X.-D., Knapp, S., and Kovarik§, P. (2011). §SFB member of the 1st funding period Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection. PLoS Pathog 7: e1001345. doi: 10.1371/journal.ppat.1001345 |
| Kratochvill, F., Machacek, C., Vogl, C., Ebner, F., Sedlyarov, V., Gruber, A.R., Hartweger, H., Vielnascher, R., Karaghiosoff, M., Ruelicke, T., Mueller, M., Hofacker, I., Lang, R., and Kovarik§, P. (2011). §SFB member of the 1st funding period Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation. Mol Sys Biol 7: 560. doi: 10.1038/msb.2011.93 |
| Roetzer, A., Klopf, E., Gratz, N., Marcet-Houben, M., Hiller, E., Rupp, S., Gabaldon, T., Kovarik§, P., and Schuller, C. (2011). §SFB member of the 1st funding period Regulation of Candida glabrata oxidative stress resistance is adapted to host environment. FEBS Lett 585: 319-327. doi: 10.1016/j.febslet.2010.12.006 |
| Mair, M., Blaas, L., Osterreicher, C.H., Casanova, E., and Eferl, R. (2011). JAK-STAT signaling in hepatic fibrosis. Front Biosci 17: 2794-2811. [review] doi: http://dx.doi.org/10.2741/3886 |
| Rampetsreiter, P., Casanova, E., and Eferl, R. (2011). Genetically modified mouse models of cancer invasion and metastasis. Drug Discov Today Dis Models 8: 67-74. [review] doi: 10.1016/j.ddmod.2011.05.003 |
| van Zijl*, F., Mall*, S., Machat, G., Pirker, C., Zeilinger, R., Weinhaeusel, A., Bilban, M., Berger, W., and Mikulits, W. (2011). *equal contribution A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression. Mol Cancer Ther 10: 850-860. doi: 10.1158/1535-7163.MCT-10-0917 |
| van Zijl, F., Krupitza, G., and Mikulits, W. (2011). Initial steps of metastasis: Cell invasion and endothelial transmigration. Mutat Res 728: 23-34. [review] doi: 10.1016/j.mrrev.2011.05.002 |
| Ermakova, O., Piszczek, L., Luciani, L., Cavalli, F.M., Ferreira, T., Farley, D., Rizzo, S., Paolicelli, R.C., Al-Banchaabouchi, M., Nerlov, C., Moriggl, R., Luscombe, N.M., and Gross, C. (2011). Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med 3: 50-66. doi: 10.1002/emmm.201000112 |
| Ferbeyre, G., and Moriggl, R. (2011). The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 1815: 104-114. [review] doi: 10.1016/j.bbcan.2010.10.004 |
| Blanc, M., Hsieh, W., Robertson, K., Watterson, S., Shui, G., Lacaze, P., Khondoker, M., Dickinson, P., Sing, G., Rodriguez-Martin, S., Phelan, P., Forster, T., Strobl, B., Mueller, M., Riemersma, R., Osborne, T., Wenk, M.R., Angulo, A., and Ghazal, P. (2011). Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis. PLoS Biol 9: e1000598. doi: 10.1371/journal.pbio.1000598 |
| Grunert, T., Leitner, N.R., Marchett-Deschmann, M., Miller, I., Wallner, B., Radwan, M., Vogl, C., Kolbe, T., Kratky, D., Gemeiner, M., Allmaier, G., Mueller, M., and Strobl, B. (2011). A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C). J Proteomics 74: 2866-2880. doi: 10.1016/j.jprot.2011.07.006 |
| Kropp, K.A., Robertson, K.A., Sing, G., Rodriguez-Martin, S., Blanc, M., Lacaze, P., Noor Hassim, M.F.B., Khondoker, M.R., Busche, A., Dickinson, P., Forster, T., Strobl, B., Mueller, M., Jonjic, S., Angulo, A., and Ghazal, P. (2011). Reversible inhibition of MCMV replication by IFN{gamma} in primary macrophages involves a primed type I IFN signaling sub-network for full establishment of an immediate-early antiviral-state. J Virol 85: 10286-10299. doi: 10.1128/JVI.00373-11 |
| Pichlmair, A., Lassnig, C., Eberle, C.-A., Górna, M.W., Baumann, C.L., Burkard, T.R., Buerckstuemmer, T., Stefanovic, A., Krieger, S., Bennet, K.L., Ruelicke, T., Weber, F., Colinge, J., Mueller, M., and Superti-Furga, G. (2011). IFIT1 is an antiviral protein that recognizes 5’-triphosphate RNA. Nat Immunol 12: 624-630. doi: 10.1038/ni.2048 |
| Todoric, J., Strobl, B., Jais, A., Boucheron, N., Bayer, M., Amman, S., Lindroos, J., Teperino, R., Prager, G., Bilban, M., Ellmeier, W., Krempler, F., Mueller, M., Wagner, O., Patsch, W., Pospsilik, J.A., and Esterbauer, H. (2011). Cross-Talk Between Interferon-{gamma} and Hedgehog Signaling Regulates Adipogenesis. Diabetes 60: 1668-1676. doi: 10.2337/db10-1628 |
| Weichhart, T., Haidinger, M., Katholnig, K., Kopecky, C., Poglitsch, M., Lassnig, C., Rosner, M., Zlabinger, G.J., Hengstschläger, M., Mueller, M., Hörl, W., and Säemann, M.D. (2011). Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 117: 4273-4283. doi: http://dx.doi.org/10.1182/blood-2010-09-310888 |
| Hofmann, E., Reichart, U., Gausterer, C., Guelly, C., Meijer, D., Mueller, M., and Strobl, B. (2010). Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses. BMC Cell Biol 11: 61. doi: 10.1186/1471-2121-11-61 |
| Kollmann, K., Heller, G., Ott, R.G., Scheicher, R., Zebedin-Brandl, E., Schneckenleithner, C., Simma, O., Warsch, W., Eckelhart, E., Hoelbl, A., Bilban, M., Zochbauer-Muller, S., Malumbres, M., and Sexl, V. (2011). C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6. Blood 117: 4065-4075. doi: dx.doi.org/10.1182/blood-2010-07-299644 |
2010 Publications
| Zulehner, G., Mikula, M., Schneller, D., van Zijl, F., Huber, H., Sieghart, W., Grasl-Kraupp, B., Waldhor, T., Peck-Radosavljevic, M., Beug, H., and Mikulits, W. (2010). Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence. Am J Pathol 176: 472-481. doi: 10.2353/ajpath.2010.090300 |
| Blaas*, L., Kornfeld*, J.W., Schramek, D., Musteanu, M., Zollner, G., Gumhold, J., van Zijl, F., Schneller, D., Esterbauer, H., Egger, G., Mair, M., Kenner, L., Mikulits, W., Eferl, R., Moriggl, R., Penninger, J., Trauner, M., and Casanova, E. (2010). *equal contribution Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology 51: 1319-1326. doi: 10.1002/hep.23469 |
| Farlik, M., Reutterer, B., Schindler, C., Greten, F., Vogl, C., Mueller, M., and Decker, T. (2010). Nonconventional Initiation Complex Assembly by STAT and NF-kappaB Transcription Factors Regulates Nitric Oxide Synthase Expression. Immunity 33: 25-34. doi: 10.1016/j.immuni.2010.07.001 |
| Friedbichler, K., Kerenyi, M.A., Kovacic, B., Li, G., Hoelbl, A., Yahiaoui, S., Sexl, V., Mullner§, E.W., Fajmann, S., Cerny-Reiterer, S., Valent, P., Beug†, H., Gouilleux, F., Bunting, K.D., and Moriggl, R. (2010). §SFB member of the 1st funding period †1945-2011, SFB member of the 1st funding period; associated with coordination project Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation. Blood 116: 1548-1558. doi: 10.1182/blood-2009-12-258913 |
| Hoelbl*, A., Schuster*, C., Kovacic, B., Zhu, B., Wickre, M., Hoelzl, M.A., Fajmann, S., Grebien, F., Warsch, W., Stengl, G., Hennighausen, L., Poli, V., Beug†, H., Moriggl, R., and Sexl, V. (2010). *equal contribution †1945-2011, SFB member of the 1st funding period; associated with coordination project Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia. EMBO Mol Med 2: 98-110. doi: 10.1002/emmm.201000062 |
| Mair, M., Zollner, G., Schneller, D., Musteanu, M., Fickert, P., Gumhold, J., Schuster, C., Fuchsbichler, A., Bilban, M., Tauber, S., Esterbauer, H., Kenner, L., Poli, V., Blaas, L., Kornfeld, J.W., Casanova, E., Mikulits, W., Trauner, M., and Eferl, R. (2010). Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology 138: 2499-2508. doi: 10.1053/j.gastro.2010.02.049 |
| Musteanu, M., Blaas, L., Mair, M., Schlederer, M., Bilban, M., Tauber, S., Esterbauer, H., Mueller, M., Casanova, E., Kenner, L., Poli, V., and Eferl, R. (2010). Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology 138: 1003-1011. doi: 10.1053/j.gastro.2009.11.049 |
| Maier, H.J., Schmidt-Strassburger, U., Huber, M.A., Wiedemann, E.M., Beug†, H., and Wirth, T. (2010). †1945-2011, SFB member of the 1st funding period; associated with coordination project NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett 295: 214-228. doi: 10.1016/j.canlet.2010.03.003 |
| Maschler, S., Gebeshuber, C.A., Wiedemann, E.M., Alacakaptan, M., Schreiber, M., Custic, I., and Beug†, H. (2010). †1945-2011, SFB member of the 1st funding period; associated with coordination project Annexin A1 attenuates EMT and metastatic potential in breast cancer. EMBO Mol Med 2: 401-414. doi: 10.1002/emmm.201000095 |
| Roetzer, A., Gratz, N., Kovarik, P., and Schuller, C. (2010). Autophagy supports Candida glabrata survival during phagocytosis. Cell Microbiol 12: 199-216. doi: 10.1111/j.1462-5822.2009.01391.x |
| Khan, M., Giessrigl, B., Vonach, C., Madlener, S., Prinz, S., Herbaceck, I., Holzl, C., Bauer, S., Viola, K., Mikulits, W., Quereshi, R.A., Knasmuller, S., Grusch, M., Kopp, B., and Krupitza, G. (2010). Berberine and a Berberis lycium extract inactivate Cdc25A and induce alpha-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mutat Res 683: 123-130. doi: 10.1016/j.mrfmmm.2009.11.001 |
| van Zijl, F., and Mikulits, W. (2010). Hepatospheres: Three dimensional cell cultures resemble physiological conditions of the liver. World J Hepatol 2: 1-7. [review] doi: 10.4254/wjh.v2.i1.1 |
| Li, G., Miskimen, K.L., Wang, Z., Xie, X.Y., Brenzovich, J., Ryan, J.J., Tse, W., Moriggl, R., and Bunting, K.D. (2010). STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. Blood 115: 1416-1424. doi: 10.1182/blood-2009-07-234963 |
| Madlener, S., Saiko, P., Vonach, C., Viola, K., Huttary, N., Stark, N., Popescu, R., Gridling, M., Vo, N.T., Herbacek, I., Davidovits, A., Giessrigl, B., Venkateswarlu, S., Geleff, S., Jager, W., Grusch, M., Kerjaschki, D., Mikulits, W., Golakoti, T., Fritzer-Szekeres, M., Szekeres, T., and Krupitza, G. (2010). Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro. Br J Cancer 102: 1361-1370. doi: 10.1038/sj.bjc.6605656 |
| Grusch, M., Petz, M., Metzner, T., Ozturk, D., Schneller, D., and Mikulits, W. (2010). The Crosstalk of RAS with the TGF-beta Family during Carcinoma Progression and its Implications for Targeted Cancer Therapy. Curr Cancer Drug Targets 10: 849-857. [review] doi: 10.2174/156800910793357943 |
| Creamer, B.A., Sakamoto, K., Schmidt, J.W., Triplett, A.A., Moriggl, R., and Wagner, K.U. (2010). Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1. Mol Cell Biol 30: 2957-2970. doi: 10.1128/MCB.00851-09 |
| Li, G., Miskimen, K.L., Wang, Z., Xie, X.Y., Tse, W., Gouilleux, F., Moriggl, R., and Bunting, K.D. (2010). Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin. Leukemia 24: 1397-1405. doi: 10.1038/leu.2010.131 |
| Radwan*, M., Stiefvater*, R., Grunert, T., Sharif, O., Miller, I., Marchetti-Deschmann, M., Allmaier, G., Gemeiner, M., Knapp, S., Kovarik§, P., Mueller, M., and Strobl, B. (2010). *equal contribution §SFB member of the 1st funding period Tyrosine kinase 2 controls IL-1beta production at the translational level. J Immunol 185: 3544-3553. doi: 10.4049/jimmunol.0904000 |
| Vogl, C., Flatt, T., Fuhrmann, B., Hofmann, E., Wallner, B., Stiefvater, R., Kovarik, P., Strobl, B., and Mueller, M. (2010). Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes. BMC Genomics 11: 199. doi: 10.1186/1471-2164-11-199 |
| Beer-Hammer, S., Zebedin, E., von Holleben, M., Alferink, J., Reis, B., Dresing, P., Degrandi, D., Scheu, S., Hirsch, E., Sexl, V., Pfeffer, K., Nurnberg, B., and Piekorz, R.P. (2010). The catalytic PI3K isoforms F28110gamma and F28110delta contribute to B cell development and maintenance, transformation, and proliferation. J Leukoc Biol 87: 1083-1095. doi: 10.1189/jlb.0809585 |
2009 Publications
| Lahsnig, C., Mikula, M., Petz, M., Zulehner, G., Schneller, D., van Zijl, F., Huber, H., Csiszar, A., Beug, H. and Mikulits, W. (2009). ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene 28:638-50. doi: 10.1038/onc.2008.418 |
| Pilz, A., Kratky, W., Stockinger, S., Simma, O., Kalinke, U., Lingnau, K., von Gabain, A., Stoiber, D., Sexl, V., Kolbe, T., Rulicke, T., Mueller, M. and Decker, T. (2009). Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183:2286-93. doi: 10.4049/jimmunol.0901383 |
| Prchal, M, Pilz, A., Simma, O., Lingnau, K., von Gabain, A., Strobl, B., Mueller, M., and Decker, T. (2009). Type I interferons as mediators of immune adjuvants for T- and B cell- dependent acquired immunity. Vaccine 27 Suppl 6, G17-20. doi: 10.1016/j.vaccine.2009.10.016 |
| Schaljo, B., Kratochvill, F., Gratz, N., Sadzak, I., Sauer, I., Hammer, M., Vogl, C., Strobl, B., Mueller, M., Blackshear, P.J., Poli, V., Lang, R., Murray, P.J. and Kovarik, P. (2009). Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 183:1197-206. doi: 10.4049/jimmunol.0803883 |
| Simma, O., Zebedin, E., Neugebauer, N., Schellack, C., Pilz, A., Chang-Rodriguez, S., Lingnau, K., Weisz, E., Putz, E.M., Pickl, W.F., Felzmann, T., Mueller, M., Decker, T., Sexl, V. and Stoiber, D. (2009). Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance. Cancer Res 69:203-11. doi: 10.1158/0008-5472.CAN-08-1705 |
| Stockinger, S., Kastner, R., Kernbauer, E., Pilz, A., Westermayer, S., Reutterer, B., Soulat, D., Stengl, G., Vogl, C., Frenz, T., Waibler, Z., Taniguchi, T., Rulicke, T., Kalinke, U., Mueller, M. and Decker, T. (2009). Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes. PLoS Pathog 5, e1000355. doi: 10.1371/journal.ppat.1000355 |
| van Zijl, F., Mair, M., Csiszar, A., Schneller, D., Zulehner, G., Huber, H., Eferl, R., Beug, H., Dolznig, H., and Mikulits, W. (2009). Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 28: 4022-4033. doi: 10.1038/onc.2009.253 |
| Ecker, A., Simma, O., Hoelbl, A., Kenner, L., Beug, H., Moriggl, R. and Sexl, V. (2009). The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor. Front Biosci 14:2944-58. [review] doi: dx.doi.org/10.2741/3425 |
| Friedbichler, K., Kerenyi, M.A., Muellner, E.W. and Moriggl, R. (2009). Stat5 as hematopoietic gatekeeper and oncogene upon tyrosine kinase-induced transformation. In JAK-STAT Pathways in Disease (Stephanou, A., Ed.). Landes Biosci, Austin, TX. pp. 131-150. [book chapter] ISBN-13: 978-1587063152 |
| Aly, S., Mages, J., Reiling, N., Kalinke, U., Decker, T., Lang, R. and Ehlers, S. (2009). Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med 13:2069-2082. doi: 10.1111/j.1582-4934.2008.00470.x |
| Grundtner, P., Gruber, S., Murray, S.S., Vermeire, S., Rutgeerts, P., Decker, T., Lakatos, P.L. and Gasche, C. (2009). The IL10R1 S138G loss-of-function allele and ulcerative colitis. Genes Immun 10:84-92. doi: 10.1038/gene.2008.72 |
| Maldonado, R.A., Soriano, M.A., Perdomo, C., Sigrist, K., Irvine, D.J., Decker, T. and Glimcher, L.H. (2009). Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med 206(4):877-92. doi: 10.1084/jem.20082900 |
| Plumlee, C.R., Lee, C., Song, L., Prince, A., Beg, A., Decker, T., Shuman, H.A. and. Schindler, C. (2009). Interferons direct an effective innate response to Legionella pneumophila infection. J Biol Chem 284:30058-30066. doi: 10.1074/jbc.M109.018283 |
| Stockinger, S. and Decker, T. (2009). STATs and infection. In JAK-STAT Pathways in Disease (Stephanou, A., Ed.). Landes Biosci, Austin, TX. pp. 43-57. [book chapter] ISBN-13: 978-1587063152 |
| Blaas, L., Musteanu, M., Eferl, R., Bauer, A. and Casanova, E. (2009). Bacterial artificial chromosomes improve recombinant protein production in mammalian cells. BMC Biotechnol 9:3. doi: 10.1186/1472-6750-9-3 |
| Lahsnig, C., Mikula, M., Petz, M., Zulehner, G., Schneller, D., van Zijl, F., Huber, H., Csiszar, A., Beug, H., and Mikulits, W. (2009). ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene 28: 638-650. doi: 10.1038/onc.2008.418 |
| Macheiner, D., Gauglhofer, C., Rodgarkia-Dara, C., Grusch, M., Brachner, A., Bichler, C., Kandioler, D., Sutterluty, H., Mikulits, W., Schulte-Hermann, R., and Grasl-Kraupp, B. (2009). NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A. Cancer Res 69: 235-242. doi: 10.1158/0008-5472.CAN-08-2144 |
| van Zijl, F., Zulehner, G., Petz, M., Schneller, D., Kornauth, C., Hau, M., Machat, G., Grubinger, M., Huber, H. and Mikulits, W. (2009). Epithelial to mesenchymal transition in hepatocellular carcinoma. Fut Oncol 5(8): 1169-79. [review] doi: 10.2217/fon.09.91 |
| Baumgartner, C., Sonneck, K., Mayerhofer, M., Gleixner, K., Fritz, R., Cerny-Reiterer, S., Kerenyi, M., Kornfeld, J.W., Sillaber, C., Moriggl, R. and Valent, P. (2009). Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V. American J Pathol 75(6):2416-29. doi: 10.2353/ajpath.2009.080953 |
| Pflegerl, P., Vesely, P., Hantusch, B., Schlederer, M., Zenz, R., Janig, E., Steiner, G., Meixner, A., Petzelbauer, P., Wolf, P., Soleiman, A., Egger, G., Moriggl, R., Kishimoto, T., Wagner, E.F., and Kenner, L. (2009). Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proc Natl Acad Sci USA 106: 20423-20428. doi: 10.1073/pnas.0910371106 |
| Schnidar, H., Eberl, M., Klingler, S., Mangelberger, D., Kasper, M., Hauser-Kronberger, C., Regl, G., Kroismayr, R., Moriggl, R., Sibilia, M. and Aberger, F. (2009). Epidermal growth factor receptor signaling synergizes with hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res 69:1284-92. doi: 10.1158/0008-5472.CAN-08-2331 |
2008 Publications
| Grebien, F., Kerenyi, M.A., Kovacic, B., Kolbe, T., Becker, V., Dolznig, H., Pfeffer, K., Klingmuller, U., Mueller, M., Beug, H., Muellner*, E.W. and Moriggl*, R. (2008). *equal contribution and equal correspondence Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood 111:4511-22. doi: http://dx.doi.org/10.1182/blood-2007-07-102848 |
| Grech, G., Blazquez-Domingo, M., Kolbus, A., Bakker, W.J., Muellner, E.W., Beug, H. and von Lindern, M. (2008). Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation. Blood 112:2750-60. doi: http://dx.doi.org/10.1182/blood-2008-01-133140 |
| Kerenyi*, M.A., Grebien*, F., Gehart, H., Schifrer, M., Artaker, M., Kovacic, B., Beug, H., Moriggl, R. and Muellner, E.W. (2008). *equal contribution Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood 112:3878-88. doi: 10.1182/blood-2008-02-138339 |
| Mayerhofer, M., Gleixner, K.V., Hoelbl, A., Florian, S., Hoermann, G., Aichberger, K.J., Bilban, M., Esterbauer, H., Krauth, M.T., Sperr, W.R., Longley, J.B., Kralovic, R., Moriggl, R., Zappulla, J., Liblau, R.S., Schwarzinger, I., Sexl, V., Sillaber, C. and Valent, P. (2008). Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens. J Immunol 180:5466-76. doi: 10.4049/jimmunol.180.8.5466 |
| Reutterer, B., Stockinger, S., Pilz, A., Soulat, S., Kastner, R., Westermayer, S., Ruelicke, T., Mueller, M. and Decker, T. (2008). Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence. Cell Microbiol 10:1116-29. doi: 10.1111/j.1462-5822.2007.01114.x |
| Schuster, C., Mueller, M., Freissmuth, M., Sexl, V. and Stoiber, D. (2008). Commentary on H.Ide et al: “Tyk2 expression and its signaling enhances invasiveness of prostate cancer cellsâ€. Biochem Biophys Res Commun 366:869-70. doi: 10.1016/j.bbrc.2007.12.017 |
| Kornfeld, J.W., Grebien, F., Kerenyi, M.A., Friedbichler, K., Kovacic, B., Zankl, B., Hoelbl, A., Nivarti, H., Beug, H., Sexl, V., Mueller, M., Kenner, L., Muellner, E.W., Gouilleux, F. and Moriggl, R. (2008). The different functions of Stat5 and chromatin alteration through Stat5 proteins. Front Biosci 13:6237-54. [review] doi: dx.doi.org/10.2741/3151 |
| Gal, A., Sjöblom, T., Fedorova, L., Imreh, S., Beug, H., and Moustakas, A. (2008). Sustained TGFbeta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene 27: 1218-1230. doi: 10.1038/sj.onc.1210741 |
| Huber, M., Steinwald, V., Guralnik, A., Bruestle, A., Kleemann, P., Rosenplänter, C., Decker, T. and Lohoff, M. (2008). IL-27 inhibits the development of regulatory T cells via STAT3. Int Immunol 20:223-34. doi: 10.1093/intimm/dxm139 |
| Soulat, D., Buerckstuemmer, T., Westermayer, S., Goncalves, A., Bauch, A., Preradovic, A., Hantschel, O., Bennett, K.L., Decker*, T. and Superti-Furga*, G. (2008). *corresponding authors The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J 27:2135-46. doi: 10.1038/emboj.2008.126 |
| Zwaferink, H., Stockinger, S., Hazemi, P., Lemmens-Gruber, R. and Decker, T. (2008). IFNβ increases Listeriolysin O-induced membrane permeabilisation and death of macrophages. J Immunol 180:4116-23. doi: 10.4049/jimmunol.180.6.4116 |
| Zwaferink, H., Stockinger, S., Reipert, S. and Decker, T. (2008). Stimulation of inducible nitric oxide synthase expression by interferon beta increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect Immun 76:1649-56. doi: 10.1128/IAI.01251-07 |
| von Gabain, A., Nagy, E. and Decker, T. (2008). Novel paradigms in vaccine development: from small pox eradication to therapeutic vaccines. Biol Chem 389:455-6. [commentary] doi: 10.1515/BC.2008.067 |
| Stockinger, S. and Decker, T. (2008). New functions of type I interferons revealed by infection studies with Listeria monocytogenes. Immunobiol 213:889-97. [review] doi: 10.1016/j.imbio.2008.07.020 |
| Eferl, R., Hasselblatt, P., Rath, M., Popper, H., Zenz, R., Komnenovic, V., Idarraga, M.H., Kenner, L. and Wagner, E.F. (2008). Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. Proc Natl Acad Sci USA 105:10525-30. doi: 10.1073/pnas.0801414105 |
| Zenz, R., Eferl, R., Scheinecker, C., Redlich, K., Smolen, J., Schonthaler, H.B., Kenner, L., Tschachler, E. and Wagner, E.F. (2008). Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease. Arthritis Res Ther 10:201. doi: 10.1186/ar2338 |
| Sadzak, I., Schiff, M., Gattermeier, I., Glinitzer, R., Sauer, I., Saalmuller, A., Yang, E., Schaljo, B. and Kovarik, P. (2008). Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci USA 105:8944-9. (selected by the Faculty 1000 Biology) doi: 10.1073/pnas.0801794105 |
| Gratz, N., Siller, M., Schaljo, B., Pirzada, Z.A., Gattermeier, I., Vojtek, I., Kirschning, C.J., Wagner, H., Akira, S., Charpentier, E. and Kovarik, P. (2008). Group A streptococcus activates type I interferon Production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9. J Biol Chem 283:19879-87. doi: 10.1074/jbc.M802848200 |
| Harir, N., Boudot, C., Friedbichler, K., Sonneck, K., Kondo, R., Martin-Lanneree, S., Kenner, L., Kerenyi, M., Yahiaoui, S., Gouilleux-Gruart, V., Gondry, J., Benit, L., Dusanter-Fourt, I., Lassoued, K., Valent, P., Moriggl*, R. and Gouilleux* F. (2008). *equal contribution and equal correspondence Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade. Blood 112:2463-73. doi: 10.1182/blood-2007-09-115477 |
| Tsyrulnyk, A. and Moriggl, R. (2008). A detailed protocol for bacterial artificial chromosome recombineering to study essential genes in stem cells. Hematopoietic Stem Cell Protocols. Methods in Molecular BiologyTM, Humana Press. 430:269-293. [book chapter] doi: 10.1007/978-1-59745-182-6_19 Online ISBN: 978-1-59745-182-6 |
| Costantino, G., Egerbacher, M., Kolbe, T., Karaghiosoff, M., Strobl§, B., Vogl, C., Helmreich, M. and Mueller, M. (2008). §SFB member of the 2nd and 3rd funding period Tyk2 and signal transducer and activator of transcription 1 contribute to intestinal I/R injury. Shock 29:238-44. doi: 10.1097/shk.0b013e3180cab252 |
| Grunert, T., Marchetti-Deschmann, M., Miller, I., Mueller, M. and Allmaier, G. (2008). Comparing the applicability of CGE-on-the-chip and SDS-PAGE for fast pre-screening of mouse serum samples prior to proteomics analysis. Electrophoresis 29:4332-40. doi: 10.1002/elps.200800035 |
| Radwan, M., Miller, I., Grunert, T., Marchetti-Deschmann, M., Vogl, C., O'Donoghue, N., Dunn, M. J., Kolbe, T., Allmaier, G., Gemeiner, M., Mueller, M. and Strobl§, B. (2008). §SFB member of the 2nd and 3rd funding period The impact of tyrosine kinase 2 (Tyk2) on the proteome of murine macrophages and their response to lipopolysaccharide (LPS). Proteomics 8:3469-85. doi: 10.1002/pmic.200800260 |
| Schneider, A., Reichart, U., Gerner, W., Kolbe, T., Saalmueller, A. and Mueller, M. (2008). Selective contribution of Tyk2 to cell activation by lipopolysaccharide. FEBS Lett 582:3681-6. doi: 10.1016/j.febslet.2008.09.053 |
| Weichhart, T., Costantino, G., Poglitsch, M., Rosner, M., Zeyda, M., Stuhlmeier, K.M., Kolbe, T., Stulnig, T.M., Horl, W.H., Hengstschlager, M., Mueller, M. and Saemann, M.D. (2008). The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29:565-77. doi: http://dx.doi.org/10.1016/j.immuni.2008.08.012 |
| Mayerhofer, M., Gleixner, K.V., Mayerhofer, J., Hoermann, G., Jaeger, E., Aichberger, K.J., Ott, R.G., Greish, K., Nakamura, H., Derdak, S., Samorapoompichit, P., Pickl, W.F., Sexl, V., Esterbauer, H., Schwarzinger, I., Sillaber, C., Maeda, H. and Valent, P. (2008). Targeting of heat shock protein 32 (Hsp 32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myleoid leukemia. A novel approach to overcome resistance against imatinib. Blood 111:2200-14. doi: http://dx.doi.org/10.1182/blood-2006-11-055723 |
| Zebedin, E., Simma, O., Schuster, C., Putz, E.M., Fajmann, S., Warsch, W., Eckelhart, E., Stoiber, D., Weisz, E., Schmid, J.A., Pickl, W.F., Baumgartner, C., Valent, P., Piekorz, R.P., Freissmuth, M. and Sexl, V. (2008). Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance. Blood 112:4655-64. doi: 10.1182/blood-2008-02-139105 |
2007 Publications
| Aigner, K, Descovich, L, Mikula, M, Sultan, A, Dampier, B, Bonne, S, van Roy, F, Mikulits, W, Schreiber, M, Brabletz, T, Sommergruber, W, Schweifer, N, Wernitznig, A, Beug, H, Foisner, R, and Eger, A (2007). The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS Lett 581: 1617-1624. doi: 10.1016/j.febslet.2007.03.026 |
| Aigner, K, Dampier, B, Descovich, L, Mikula, M, Sultan, A, Schreiber, M, Mikulits, W, Brabletz, T, Strand, D, Obrist, P, Sommergruber, W, Schweifer, N, Wernitznig, A, Beug, H, Foisner, R, and Eger, A (2007). The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 26: 3395-3405. doi: 10.1038/sj.onc.1210508 |
| Engblom, D., Kornfeld, J.W., Schwake, L., Tronche, F., Reimann, A., Beug, H., Hennighausen, L., Moriggl*, R. and Schuetz*, G. (2007). *equal contribution and equal correspondence Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev 21:1157-62. doi: 10.1101/gad.426007 |
| Fischer, A.N., Fuchs, E., Mikula, M., Huber, H., Beug, H. and Mikulits, W. (2007). PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene 26 (23):3395-405. doi: 10.1038/sj.onc.1210121 |
| Harir, N., Pecquet, C., Kerenyi, M., Sonneck, K., Kovacic, B., Nyga, R., Brevet, M., Dhennin, I., Gouilleux-Gruart, V., Beug, H., Valent, P., Lassoued, K., Moriggl, R. and Gouilleux, F. (2007). Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood 109:1678-86. doi: http://dx.doi.org/10.1182/blood-2006-01-029918 |
| Mikula, M., Lahsnig, C., Fischer, A.N.M., Proell, V., Huber, H., Fuchs, E., Eger, A., Beug, H. and Mikulits, W. (2007). Epithelial plasticity of hepatocytes during liver tumor progression. (Bilko, N.M., et al., Eds.), Stem Cells and their Potential for Clinical Application, 123–135, Springer. [book chapter] doi: 10.1007/978-1-4020-6469-2_9 ISBN 978-1-4020-6468-5 |
| Hui, L., Bakiri, L., Mairhorfer, A., Schweifer, N., Haslinger, C., Kenner, L., Komnenovic, V., Scheuch, H., Beug, H., and Wagner, E. F. (2007). p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Genet 39:741-9. doi: 10.1038/ng2033 |
| Ramsauer, K., Farlik, M., Zupkovitz, G., Seiser, C., Kröger, A., Hauser, H.J. and Decker, T. (2007). Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-γ-inducible gbp2 gene. Proc Natl Acad Sci USA 104:2849-54. doi: 10.1073/pnas.0610944104 |
| Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K.A., Irvine, K.M., Burrows, A.D., Ravasi, T., Weighardt, H., Stacey, K.J., Decker, T., Hume, D.A., Dalpke, A.H. and Sweet, M.J. (2007). Differential effects of CpG DNA on IFNβ induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates toll-like receptor signalling in macrophages. J Immunol 179(6):3495-503. doi: 10.4049/jimmunol.179.6.3495 |
| Werts, C., Le Bourhis, L., Liu, J., Magalhaes, J.G., Fritz, J.H., Stockinger, S., Decker, T., Philpott, D., Ma, X. and Girardin, S.E. (2007). Nod1 and Nod2 induce CCL5/RANTES through the NFκB pathway. Eur J Immunol 37(9):2499-508. doi: 10.1002/eji.200737069 |
| Blaas, L., Musteanu, M., Zenz, R., Eferl, R. and Casanova, E. (2007). PhiC31-mediated cassette exchange into a bacterial artificial chromosome. BioTechniques 43:659-64. doi: 10.2144/000112592 |
| Bakiri, L., Takada, Y., Radolf, M., Eferl, R., Yaniv, M., Wagner, E.F. and Matsuo, K. (2007). Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation. Bone 40:867-75. doi: http://dx.doi.org/10.1016/j.bone.2006.11.005 |
| Eferl, R., Zenz, R., Theussl, H.C. and Wagner, E.F. (2007). Simultaneous generation of fra-2 conditional and fra-2 knock-out mice. Genesis 45:447-51. doi: 10.1002/dvg.20311 |
| Piskacek, S., Gregor, M., Nemethova, M., Grabner, M., Kovarik, P.* and Piskacek, M.* (2007). *corresponding authors Nine-amino-acid transactivation domain: establishment and prediction utilities. Genomics 89:756-68. doi: 10.1016/j.ygeno.2007.02.003 |
| Kovarik, P., Sauer, I. and Schaljo, B. (2007). Molecular mechanisms of the anti-inflammatory functions of interferons. Immunobiol 212: 895-901. [review] doi: 10.1016/j.imbio.2007.09.011 |
| Li, G., Wang, Z., Zhang, Y., Kang, Z., Haviernikova, E., Cui, Y., Hennighausen, L., Moriggl, R., Wang, D., Tse, W. and Bunting, K.D. (2007). STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output. Exp Hematol 35:1684-94. doi: 10.1016/j.exphem.2007.08.026 |
| Tsareva, S., Moriggl, R., Corvinus, F., Wiederanders, B., Schuetz, A., Kovacic, B., Friedrich, K. (2007). STAT3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 9:279-91. doi: 10.1593/neo.06820 |
| Tuckermann, J.P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B.E., Stride, B., Forster, I., Habenicht, A.J., Reichardt, H.M., Tronche, F., Schmid, W. and Schutz, G. (2007). Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest 117:1381-90. doi: 10.1172/JCI28034 |
| Yao, Z., Kanno, Y., Kerenyi, M., Stephens, G., Durant, L., Watford, W.T., Laurence, A., Robinson, G.W., Shevach, E.M., Moriggl, R., Hennighausen, L., Wu, C. and O'Shea, J.J. (2007). Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109:4368-75. doi: 10.1182/blood-2006-11-055756 |
| Gausterer, C., Mueller, M., and Strobl§, B. (2007). §SFB member of the 2nd and 3rd funding period In vivo target validation: Methodology and Case Studies on the Janus kinase Tyk2. Anti-Inflammatory & Anti-Allergy Agents in Medical Chemistry 6, 29-45. doi: 10.2174/187152307779939697 |
| Painz, R., Walter, I., Kolbe, T., Rigler, D., Vogl, C., Steinborn, R., Ruelicke, T., Helmreich, M., Karaghiosoff, M. and Mueller, M. (2007). Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo. Immunobiol 212:863-75. doi: 10.1016/j.imbio.2007.09.017 |
| del Prete, M.J., Vernal, R., Dolznig, H., Mullner, E.W. and Garcia-Sanz, J.A. (2007). Isolation of polysome-bound mRNA from solid tissues amenable for RT-PCR and profiling experiments. RNA 13:414-21. doi: 10.1261/rna.79407 |
| Infante, A.A., Infante, D., Chan, M.C., How, P.C., Kutschera, W., Linhartova, I., Muellner, E.W., Wiche, G. and Propst, F. (2007). Ferritin associates with marginal band microtubules. Exp Cell Res 313:1602-14. doi: 10.1016/j.yexcr.2007.02.021 |
| Ott, R.G., Simma, O., Kollmann, K., Weisz, E., Zebedin, E.M., Schorpp-Kistner, M., Heller, G., Zochbauer, S., Wagner, E.F., Freissmuth, M. and Sexl, V. (2007). Jun B is a gatekeeper for B-lymphoid leukemia. Oncogene 26:4863-71. doi: 10.1038/sj.onc.1210285 |
| Staber, P.B., Vesely, P., Haq, N., Ott, R.G., Funato, K., Bambach, I., Fuchs, C., Schauer, S., Linkesch, W., Hrzenjak, A., Dirks, W.G., Sexl, V., Bergler, H., Kadin, M.E., Sternberg, D.W., Kenner, L. and Hoefler, G. (2007). The oncoprotein NPM-ALK of anaplastic large cell lymphoma induces JUNB transcription via ERK1/2 abd JunB translation via mTOR signaling. Blood 110:3374-83. doi: http://dx.doi.org/10.1182/blood-2007-02-071258 |
2006 Publications
| Dolznig*, H., Grebien*, F., Deiner*, E.M., Stangl, K., Kolbus, A., Habermann, B., Kerenyi, M.A., Kieslinger, M., Moriggl, R., Beug§, H. and Muellner§, E.W. (2006). *equal contribution §equal contribution and equal correspondence Erythroid progenitor renewal versus differentiation: genetic evidence for cell autonomous, essential functions of EpoR, Stat5 and the GR. Oncogene 25:2890-900. doi: 10.1038/sj.onc.1209308 |
| Hoelbl, A., Kovacic, B., Kerenyi, M.A., Simma, O., Warsch, W., Cui, Y., Beug, H., Hennighausen, L., Moriggl, R. and Sexl, V. (2006). Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation. Blood 107:4898-906. doi: 10.1182/blood-2005-09-3596 |
| Jechlinger, M., Sommer, A., Moriggl, R., Seither, P., Kraut, N., Capodiecci, P., Donovan, M., Cordon-Cardo, C., Beug, H. and Grunert, S. (2006). Autocrine PDGFR signaling promotes mammary cancer metastasis. J Clin Invest 116:1561-70. doi: 10.1172/JCI24652 |
| Kovacic, B., Stoiber, D., Moriggl, R., Weisz, E., Ott, R. G., Kreibich, R., Levy, D.E., Beug, H., Freissmuth, M., and Sexl, V. (2006). STAT1 acts as a tumor promoter for leukemia development. Cancer Cell 10:77-87. |
| Sauer, I., Schaljo, B., Vogl, C., Gattermeier, I., Kolbe, T., Mueller, M., Blackshear, P.J. and Kovarik, P. (2006). Interferons limit inflammatory responses by induction of tristetraprolin. Blood 107:4790-7. doi: http://dx.doi.org/10.1182/blood-2005-07-3058 |
| Schranzhofer, M., Schifrer, M., Cabrera, J.A., Kopp, S., Chiba, P., Beug, H. and Muellner, E.W. (2006). Remodeling the regulation of iron metabolism during erythroid differentiation to ensure efficient heme biosynthesis. Blood 107:4159-67. doi: http://dx.doi.org/10.1182/blood-2005-05-1809 |
| Waerner*, T., Alacakaptan*, M., Tamir, I., Oberauer, R., Gal, A., Brabletz, T., Schreiber, M., Jechlinger, M. and Beug, H. (2006). *equal contribution ILEI: a cytokine essential for EMT, tumor formation, and late events in metastasis in epithelial cells. Cancer Cell 10:227-39. doi: http://dx.doi.org/10.1016/j.ccr.2006.07.020 |
| Stepniak*, E., Ricci*, R., Eferl*, R., Sumara, G., Sumara, I., Rath, M., Hui, L. and Wagner, E. F. (2006). *equal contribution c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 20: 2306-14. doi: 10.1101/gad.390506 |
| Mikula, M., Proell, V., Fischer, A.N.M. and Mikulits, W. (2006). Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-ï¢ dependent fashion. J Cell Physiol 209:560-7. doi: 10.1002/jcp.20772 |
| Leitner, N.R., Strobl§, B., Bokor, M., Painz, R., Kolbe, T., Ruelicke, T., Mueller, M. and Karaghiosoff, M. (2006). §SFB member of the 2nd and 3rd funding period A time- and dose-dependent STAT1 expression system. BMC Biotechnol 6:48. doi: 10.1186/1472-6750-6-48 |
| Mikhael, M., Kim, S.F., Schranzhofer, M., Soe-Lin, S., Sheftel, A.D., Muellner, E.W. and Ponka, P. (2006). Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide. FEBS J 273:3828-36. doi: 10.1111/j.1742-4658.2006.05390.x |