The main output of curiosity driven research are the publications in peer-reviewed journals. While journal metrics have been criticized as a quality measure for research output, nevertheless the body of published results over an extensive period of time represents an important aspect of the recognition research teams have in the field.
Here we present the publications, which are based on the research at least with partial funding from the current SFB-F61 “Hierarchies and Monarchies” and its predecessor, SFB-F28 “Jak-Stat Signalling: from Basics to Disease”. Due to the extensive time publications require to become published we manuscripts frequently become published beyond the lifetime of individual projects.
2020 Publications
| Abdeldayem, A., Raouf, Y. S., Constantinescu, S. N., Moriggl, R. and Gunning, P. T. Advances in covalent kinase inhibitors Chem Soc Rev. 2020 Mar 30. doi: 10.1039/c9cs00720b |
| Gracey, E., Hromadova, D., Lim, M., Qaiyum, Z., Zeng, M., Yao, Y., Srinath, A., Baglaenko, Y., Yeremenko, N., Westlin, W., Masse, C., Muller, M., Strobl, B., Miao, W. and Inman, R. D. TYK2 inhibition reduces type 3 immunity and modifies disease progression in murine spondyloarthritis J Clin Invest. 2020 Mar 9. pii: 126567. doi: 10.1172/JCI126567 |
| Hadzijusufovic, E., Keller, A., Berger, D., Greiner, G., Wingelhofer, B., Witzeneder, N., Ivanov, D., Pecnard, E., Nivarthi, H., Schur, F. K. M., Filik, Y., Kornauth, C., Neubauer, H. A., Mullauer, L., Tin, G., Park, J., de Araujo, E. D., Gunning, P. T., Hoermann, G., Gouilleux, F., Kralovics, R., Moriggl, R. and Valent, P. STAT5 is Expressed in CD34(+)/CD38(-) Stem Cells and Serves as a Potential Molecular Target in Ph-Negative Myeloproliferative Neoplasms Cancers (Basel). 2020 Apr 21;12(4). pii: cancers12041021. doi: 10.3390/cancers12041021 |
| Kadekar, D., Agerholm, R., Rizk, J., Neubauer, H. A., Suske, T., Maurer, B., Vinals, M. T., Comelli, E. M., Taibi, A., Moriggl, R. and Bekiaris, V. The neonatal microenvironment programs innate gammadelta T cells through the transcription factor STAT5 J Clin Invest. 2020 Apr 13. pii: 131241. doi: 10.1172/JCI131241 |
| Karjalainen, A., Shoebridge, S., Krunic, M., Simonovic, N., Tebb, G., Macho-Maschler, S., Strobl, B. and Müller, M. TYK2 in Tumor Immunosurveillance Cancers (Basel). 2020 Jan 8; 12 (1):E150. 10.3390/cancers12010150 |
| Lehmann, F. M., von Burg, N., Ivanek, R., Teufel, C., Horvath, E., Peter, A., Turchinovich, G., Staehli, D., Eichlisberger, T., Gomez de Aguero, M., Coto-Llerena, M., Prchal-Murphy, M., Sexl, V., Bentires-Alj, M., Mueller, C. and Finke, D. Microbiota-induced tissue signals regulate ILC3-mediated antigen presentation Nat Commun. 2020 Apr 14;11(1):1794. doi: 10.1038/s41467-020-15612-2 |
| Maurer, B., Nivarthi, H., Wingelhofer, B., Pham, H. T. T., Schlederer, M., Suske, T., Grausenburger, R., Schiefer, A. I., Prchal-Murphy, M., Chen, D., Winkler, S., Merkel, O., Kornauth, C., Hofbauer, M., Hochgatterer, B., Hoermann, G., Hoelbl-Kovacic, A., Prochazkova, J., Lobello, C., Cumaraswamy, A. A., Latzka, J., Kitzwogerer, M., Chott, A., Janikova, A., Pospisilova, S., Loizou, J. I., Kubicek, S., Valent, P., Kolbe, T., Grebien, F., Kenner, L., Gunning, P. T., Kralovics, R., Herling, M., Muller, M., Rulicke, T., Sexl, V. and Moriggl, R. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia Haematologica. 2019 May 23. pii: haematol.2019.216986. doi: 10.3324/haematol.2019.216986 |
| Pedersen, M.S., Müller, M., Rülicke, T., Leitner, N., Kain, R., Regele, H., Wang, S., Groene, H.-J., Haller, H., Gueler, F., Rees, A.J. and Kerjaschki, D. Lymphangiogenesis in experimental renal transplant rejection extends life span of the recipients in a mouse model Kidney Int. 2019 Sept 3;97(1):89-94. doi: 10.1016/ j.kint.2019.07.027 |
| Schmoellerl, J., Barbosa, I. A. M., Eder, T., Brandstoetter, T., Schmidt, L., Maurer, B., Troester, S., Pham, H. T. T., Sagarajit, M., Ebner, J., Manhart, G., Aslan, E., Terlecki-Zaniewicz, S., Van der Veen, C., Hoermann, G., Duployez, N., Petit, A., Lapillonne, H., Puissant, A., Itzykson, R. A., Moriggl, R. H., Heuser, M., Meisel, R., Valent, P., Sexl, V., Zuber, J. and Grebien, F. CDK6 is an essential direct target of NUP98-fusion proteins in acute myeloid leukemia Blood. 2020 Apr 28. pii: 454667. doi: 10.1182/blood.2019003267 |
| Unterleuthner, D., Neuhold, P., Schwarz, K., Janker, L., Neuditschko, B., Nivarthi, H., Crncec, I., Kramer, N., Unger, C., Hengstschlager, M., Eferl, R., Moriggl, R., Sommergruber, W., Gerner, C. and Dolznig, H. Cancer-associated fibroblast-derived WNT2 increases tumor angiogenesis in colon cancer Angiogenesis. 2019 Oct 30. pii: 10.1007/s10456-019-09688-8. doi: 10.1007/s10456-019-09688-8 |
| Vargas-Hernandez, A., Witalisz-Siepracka, A., Prchal-Murphy, M., Klein, K., Mahapatra, S., Al-Herz, W., Mace, E. M., Carisey, A. F., Orange, J. S., Sexl, V. and Forbes, L. R. Human STAT5b mutation causes dysregulated human natural killer cell maturation and impaired lytic function J Allergy Clin Immunol. 2019 Oct 7. pii: S0091-6749(19)31252-7. doi: 10.1016/j.jaci.2019.09.016 |
2019 Publications
| de Araujo, E. D., Orlova, A., Neubauer, H. A., Bajusz, D., Seo, H. S., Dhe-Paganon, S., Keseru, G. M., Moriggl, R. and Gunning, P. T. Structural Implications of STAT3 and STAT5 SH2 Domain Mutations Cancers (Basel). 2019 Nov 8;11(11). pii: cancers11111757. doi: 10.3390/cancers11111757 |
| Gotthardt, D., Trifinopoulos, J., Sexl, V. and Putz, E. M. JAK/STAT Cytokine Signaling at the Crossroad of NK Cell Development and Maturation Front Immunol. 2019 Nov 12;10:2590. doi: 10.3389/fimmu.2019.02590. eCollection 2019 |
| Halbritter, F., Farlik, M., Schwentner, R., Jug, G., Fortelny, N., Schnoller, T., Pisa, H., Schuster, L. C., Reinprecht, A., Czech, T., Gojo, J., Holter, W., Minkov, M., Bauer, W. M., Simonitsch-Klupp, I., Bock, C. and Hutter, C. Epigenomics and Single-cell Sequencing Define a Developmental Hierarchy in Langerhans Cell Histiocytosis Journal: Cancer Discov Cancer Discov. 2019 Jul 25. pii: 2159-8290.CD-19-0138. doi: 10.1158/2159-8290.CD-19-0138 |
| Kaltenecker, D., Themanns, M., Mueller, K.M., Spirk, K., Suske, T., Merkel, O., Kenner, L., Luís, A., Kozlov, A., Haybaeck, J., Müller, M., Han, X. and Moriggl, R. Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression Cytokine 2019 Oct 30;124:154569. doi: 10.1016/j.cyto.2018.10.010 |
| Menzl, I., Zhang, T., Berger-Becvar, A., Grausenburger, R., Heller, G., Prchal-Murphy, M., Edlinger, L., Knab, V. M., Uras, I. Z., Grundschober, E., Bauer, K., Roth, M., Skucha, A., Liu, Y., Hatcher, J. M., Liang, Y., Kwiatkowski, N. P., Fux, D., Hoelbl-Kovacic, A., Kubicek, S., Melo, J. V., Valent, P., Weichhart, T., Grebien, F., Zuber, J., Gray, N. S. and Sexl, V. A kinase-independent role for CDK8 in BCR-ABL1(+) leukemia Nat Commun. 2019 Oct 18;10(1):4741. doi: 10.1038/s41467-019-12656-x |
| Orlova, A., Wagner, C., de Araujo, E. D., Bajusz, D., Neubauer, H. A., Herling, M., Gunning, P. T., Keseru, G. M. and Moriggl, R. Direct Targeting Options for STAT3 and STAT5 in Cancer Cancers (Basel). 2019 Dec 3;11(12). pii: cancers11121930. doi: 10.3390/cancers11121930 |
| Klein, K., Witalisz-Siepracka, A., Maurer, B., Prinz, D., Heller, G., Leidenfrost, N., Prchal-Murphy, M., Suske, T., Moriggl, R. and Sexl, V. STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia Leukemia. 2019 Apr 9. pii: 10.1038/s41375-019-0471-3. doi: 10.1038/s41375-019-0471-3 |
| Orlova, A., Neubauer, H. A. and Moriggl, R. The stromal microenvironment provides an escape route from FLT3 inhibitors through the GAS6-AXL-STAT5 axis Haematologica. 2019 Oct;104(10):1907-1909. doi: 10.3324/haematol.2019.225862 |
| Prutsch, N., Gurnhofer, E., Suske, T., Liang, H. C., Schlederer, M., Roos, S., Wu, L. C., Simonitsch-Klupp, I., Alvarez-Hernandez, A., Kornauth, C., Leone, D. A., Svinka, J., Eferl, R., Limberger, T., Aufinger, A., Shirsath, N., Wolf, P., Hielscher, T., Aberger, F., Schmoellerl, J., Stoiber, D., Strobl, B., Jager, U., Staber, P. B., Grebien, F., Moriggl, R., Muller, M., Inghirami, G. G., Sanda, T., Look, A. T., Turner, S. D., Kenner, L. and Merkel, O. Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma Leukemia. 2018 Aug 21. pii: 10.1038/s41375-018-0239-1. doi: 10.1038/s41375-018-0239-1 |
| Boutillon, F., Pigat, N., Sala, L. S., Reyes-Gomez, E., Moriggl, R., Guidotti, J. E. and Goffin, V. STAT5a/b Deficiency Delays, but does not Prevent, Prolactin-Driven Prostate Tumorigenesis in Mice Cancers (Basel). 2019 Jul 2;11(7). pii: cancers11070929. doi: 10.3390/cancers11070929 |
| Aigner, P., Mizutani, T., Horvath, J., Eder, T., Heber, S., Lind, K., Just, V., Moll, H. P., Yeroslaviz, A., Fischer, M. J. M., Kenner, L., Gyorffy, B., Sill, H., Grebien, F., Moriggl, R., Casanova, E. and Stoiber, D. STAT3beta is a tumor suppressor in acute myeloid leukemia Blood Adv. 2019 Jul 9;3(13):1989-2002. doi: 10.1182/bloodadvances.2018026385 |
| Platanitis, E., Demiroz, D., Schneller, A., Fischer, K., Capelle, C., Hartl, M., Gossenreiter, T., Muller, M., Novatchkova, M. and Decker, T. A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription Nat Commun. 2019 Jul 2;10(1):2921. doi: 10.1038/s41467-019-10970-y |
| Menzl, I., Witalisz-Siepracka, A. and Sexl, V. CDK8-Novel Therapeutic Opportunities Pharmaceuticals (Basel). 2019 Jun 19;12(2). pii: ph12020092. doi: 10.3390/ph12020092 |
| Maurer, B., Nivarthi, H., Wingelhofer, B., Pham, H. T. T., Schlederer, M., Suske, T., Grausenburger, R., Schiefer, A. I., Prchal-Murphy, M., Chen, D., Winkler, S., Merkel, O., Kornauth, C., Hofbauer, M., Hochgatterer, B., Hoermann, G., Hoelbl-Kovacic, A., Prochazkova, J., Lobello, C., Cumaraswamy, A. A., Latzka, J., Kitzwogerer, M., Chott, A., Janikova, A., Pospisilova, S., Loizou, J. I., Kubicek, S., Valent, P., Kolbe, T., Grebien, F., Kenner, L., Gunning, P. T., Kralovics, R., Herling, M., Muller, M., Rulicke, T., Sexl, V. and Moriggl, R. High activation of STAT5A drives peripheral T-cell lymphoma and leukemia Haematologica. 2019 May 23. pii: haematol.2019.216986. doi: 10.3324/haematol.2019.216986 |
| de Araujo, E. D., Erdogan, F., Neubauer, H. A., Meneksedag-Erol, D., Manaswiyoungkul, P., Eram, M. S., Seo, H. S., Qadree, A. K., Israelian, J., Orlova, A., Suske, T., Pham, H. T. T., Boersma, A., Tangermann, S., Kenner, L., Rulicke, T., Dong, A., Ravichandran, M., Brown, P. J., Audette, G. F., Rauscher, S., Dhe-Paganon, S., Moriggl, R. and Gunning, P. T. Structural and functional consequences of the STAT5B(N642H) driver mutation Nat Commun. 2019 Jun 7;10(1):2517. doi: 10.1038/s41467-019-10422-7 |
| Klein, K., Witalisz-Siepracka, A., Maurer, B., Prinz, D., Heller, G., Leidenfrost, N., Prchal-Murphy, M., Suske, T., Moriggl, R. and Sexl, V. STAT5B(N642H) drives transformation of NKT cells: a novel mouse model for CD56(+) T-LGL leukemia Leukemia. 2019 Apr 9. pii: 10.1038/s41375-019-0471-3. doi: 10.1038/s41375-019-0471-3 |
| Liu, R., Moriggl, R., Zhang, D., Li, H., Karns, R., Ruan, H. B., Niu, H., Mayhew, C., Watson, C., Bangar, H., Cha, S. W., Haslam, D., Zhang, T., Gilbert, S., Li, N., Helmrath, M., Wells, J., Denson, L. and Han, X. Constitutive STAT5 activation regulates Paneth and Paneth-like cells to control Clostridium difficile colitis Life Sci Alliance. 2019 Apr 4;2(2). pii: 2/2/e201900296. doi: 10.26508/lsa.201900296 |
| Witalisz-Siepracka, A., Klein, K., Ptinz, D., Leidenfrost, N., Schabbauer, G., Dohnal, A. and Sexl, V. Loss of JAK1 Drives Innate Immune Deficiency Front Immunol. 2019; 9(3108). doi:10.3389/fimmu.2018.03108 |
| Simonovic, N., Witalisz-Siepracka, A., Meissl, K., Lassnig, C., Reichart, U., Kolbe, T., Farlik, M., Bock, C., Sexl, V., Müller, M. and Strobl, B. NK Cells Require Cell-Extrinsic and -Intrinsic TYK2 for Full Functionality in Tumor Surveillance and Antibacterial Immunity J Immunol. 2019 Feb 4. pii: jimmunol.1701649. doi: 10.4049/jimmunol.1701649 |
| Rauth, M., Freund, P., Orlova, A., Grunert, S., Tasic, N., Han, X., Ruan, H. B., Neubauer, H. A. and Moriggl, R. Cell Metabolism Control Through O-GlcNAcylation of STAT5: A Full or Empty Fuel Tank Makes a Big Difference for Cancer Cell Growth and Survival Int J Mol Sci. 2019 Feb 27;20(5). pii: ijms20051028. doi: 10.3390/ijms20051028 |
| Kosack, L., Wingelhofer, B., Popa, A., Orlova, A., Agerer, B., Vilagos, B., Majek, P., Parapatics, K., Lercher, A., Ringler, A., Klughammer, J., Smyth, M., Khamina, K., Baazim, H., de Araujo, E. D., Rosa, D. A., Park, J., Tin, G., Ahmar, S., Gunning, P. T., Bock, C., Siddle, H. V., Woods, G. M., Kubicek, S., Murchison, E. P., Bennett, K. L., Moriggl, R. and Bergthaler, A. The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease Cancer Cell. 2019 Jan 14;35(1):125-139.e9. doi: 10.1016/j.ccell.2018.11.018 |
| Kollmann, S., Grundschober, E., Maurer, B., Warsch, W., Grausenburger, R., Edlinger, L., Huuhtanen, J., Lagger, S., Hennighausen, L., Valent, P., Decker, T., Strobl, B., Mueller, M., Mustjoki, S., Hoelbl-Kovacic, A. and Sexl, V. Twins with different personalities: STAT5B-but not STAT5A-has a key role in BCR/ABL-induced leukemia Leukemia. 2019 Jan 24. pii: 10.1038/s41375-018-0369-5. doi: 10.1038/s41375-018-0369-5 |
| Gawish, R., Bulat, T., Biaggio, M., Lassnig, C., Bago-Horvath, Z., Macho-Maschler, S., Poelzl, A., Simonovic, N., Prchal-Murphy, M., Rom, R., Amenitsch, L., Ferrarese, L., Kornhoff, J., Lederer, T., Svinka, J., Eferl, R., Bosmann, M., Kalinke, U., Stoiber, D., Sexl, V., Krmpotic, A., Jonjic, S., Muller, M. and Strobl, B. Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1 Cell Rep. 2019 Feb 26;26(9):2394-2406.e5. doi: 10.1016/j.celrep.2019.02.017 |
2018 Publications
| Wingelhofer, B., Neubauer, H.A., Valent, P., Han, X., Constantinescu, S., Gunning, P.T., Müller, M. and Moriggl, R. Implications of STAT3 and STAT5 signaling on gene regulation and chromatin remodeling in hematopoietic cancer Leukemia. 2018 March 27. doi:10.1038/s41375-018-0117-x |
| Willmann, M., Hadzijusufovic, E., Hermine, O., Dacasto, M., Marcanto, L., Bauer, K., Peter, B., Gamperl, S., Eisenwort, G., Jensen-Jarolim, E., Müller, M., Arock, M., Vail, D.M. and Valent, P. Comparative Oncology: the Paradigmatic Example of Canine and Human Mast Cell Neoplasms Vet Comp Oncol. 2018. doi:10.1111/vco.12440 |
| Szappanos, D., Tschismarov, R., Perlot, T., Westermayer, S., Fischer, K., Platanitis, E., Kallinger, F., Novatchkova, M., Lassnig, C., Müller, M., Sexl, V., Bennett, K.L., Foong-Sobis, M., Penninger, J. and Decker, T. The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity PLoS Pathog. 2018 Nov 26;14(11):e1007397. doi: 10.1371/journal.ppat.1007397 |
| Sternberg, C., Gruber, W., Eberl, M., Tesanovic, S., Stadler, M., Elmer, D. P., Schlederer, M., Grund, S., Roos, S., Wolff, F., Kaur, S., Mangelberger, D., Lehrach, H., Hache, H., Wierling, C., Laimer, J., Lackner, P., Wiederstein, M., Kasper, M., Risch, A., Petzelbauer, P., Moriggl, R., Kenner, L. and Aberger, F. Synergistic Cross-Talk of Hedgehog and Interleukin-6 Signaling Drives Growth of Basal Cell Carcinoma Int J Cancer. 2018 Jul 10. doi: 10.1002/ijc.31724 |
| Prutsch, N., Gurnhofer, E., Suske, T., Liang, H. C., Schlederer, M., Roos, S., Wu, L. C., Simonitsch-Klupp, I., Alvarez-Hernandez, A., Kornauth, C., Leone, D. A., Svinka, J., Eferl, R., Limberger, T., Aufinger, A., Shirsath, N., Wolf, P., Hielscher, T., Aberger, F., Schmoellerl, J., Stoiber, D., Strobl, B., Jager, U., Staber, P. B., Grebien, F., Moriggl, R., Muller, M., Inghirami, G. G., Sanda, T., Look, A. T., Turner, S. D., Kenner, L. and Merkel, O. Dependency on the TYK2/STAT1/MCL1 axis in anaplastic large cell lymphoma Leukemia. 2018 Aug 21. pii: 10.1038/s41375-018-0239-1. doi: 10.1038/s41375-018-0239-1 |
| Porpaczy, E., Tripolt, S., Hoelbl-Kovacic, A., Gisslinger, B., Bago-Horvath, Z., Casanova-Hevia, E., Clappier, E., Decker, T., Fajmann, S., Fux, D. A., Greiner, G., Gueltekin, S., Heller, G., Herkner, H., Hoermann, G., Kiladjian, J. J., Kolbe, T., Kornauth, C., Krauth, M. T., Kralovics, R., Muellauer, L., Mueller, M., Prchal-Murphy, M., Putz, E. M., Raffoux, E., Schiefer, A. I., Schmetterer, K., Schneckenleithner, C., Simonitsch-Klupp, I., Skrabs, C., Sperr, W. R., Staber, P. B., Strobl, B., Valent, P., Jaeger, U., Gisslinger, H. and Sexl, V. Aggressive B-cell lymphomas in patients with myelofibrosis receiving JAK1/2 inhibitor therapy Blood. 2018 Jun 14. pii: blood-2017-10-810739. doi: 10.1182/blood-2017-10-810739 |
| Platanitis, E. and Decker, T. Regulatory networks involving STATs, IRFs, and NFkB in inflammation Front Immunol. 2018 Nov 13;9:2542. doi: 10.3389/fimmu.2018.02542. eCollection 2018 |
| Pham, H. T. T., Hengstschlager, M. and Moriggl, R. A haunted beast: Targeting STAT5BN642H in T-Cell Neoplasia Mol Cell Oncol. 2018 Mar 28;5(3):e1435181. doi: 10.1080/23723556.2018.1435181. eCollection 2018. |
| Parrini, M., Meissl, K., Ola, M.J., Lederer, T., Puga, A., Wienerroither, S., Kovarik, P., Decker, T., Müller, M. and Strobl, B. The C-terminal transactivation domain of STAT1 has a gene-specific role in transactivation and cofactor recruitment Front Immunol. 2018 Dec 6;9(2879). doi: 10.3389/fimmu.2018.02879 |
| Moll, H. P., Pranz, K., Musteanu, M., Grabner, B., Hruschka, N., Mohrherr, J., Aigner, P., Stiedl, P., Brcic, L., Laszlo, V., Schramek, D., Moriggl, R., Eferl, R., Moldvay, J., Dezso, K., Lopez-Casas, P. P., Stoiber, D., Hidalgo, M., Penninger, J., Sibilia, M., Gyorffy, B., Barbacid, M., Dome, B., Popper, H. and Casanova, E. Afatinib restrains K-RAS-driven lung tumorigenesis Sci Transl Med. 2018 Jun 20;10(446). pii: 10/446/eaao2301. doi: 10.1126/scitranslmed.aao2301 |
| Kaltenecker, D., Themanns, M., Mueller, K.M., Spirk, K., Suske, T., Merkel, O., Kenner, L., Luís, A., Kozlov, A., Haybaeck, J., Müller, M., Han, X. and Moriggl, R. Hepatic growth hormone - JAK2 - STAT5 signalling: Metabolic function, non-alcoholic fatty liver disease and hepatocellular carcinoma progression Cytokine.2018 Oct 30. doi: 10.1016/j.cyto.2018.10.010 |
| Kaltenecker, D., Themanns, M., Mueller, K. M., Spirk, K., Golob-Schwarzl, N., Friedbichler, K., Kenner, L., Haybaeck, J. and Moriggl, R. STAT5 deficiency in hepatocytes reduces diethylnitrosamine-induced liver tumorigenesis in mice Cytokine. 2018 Oct 27. pii: S1043-4666(18)30402-2. doi: 10.1016/j.cyto.2018.10.014 |
| Grohmann, M., Wiede, F., Dodd, G.T., Gurzov, E.N., Ooi, G.J., Butt, T., Rasmiena, A.A., Kaur, S., Gulati, T., Goh, P.K., Treloar, A.E., Archer, S., Brown, W.A., Muller, M., Watt, M.J., Ohara, O., McLean, C.A. and Tiganis, T. Obesity drives STAT-1-dependent NASH and STAT-3-dependent HCC Cell. 2018 Nov 15;175(5):1289-1306.e20. doi: 10.1016/j.cell.2018.09.053. Epub 2018 Oct 25 |
| Cohen, M., Giladi, A., Gorki, A. D., Solodkin, D. G., Zada, M., Hladik, A., Miklosi, A., Salame, T. M., Halpern, K. B., David, E., Itzkovitz, S., Harkany, T., Knapp, S. and Amit, I. Lung Single-Cell Signaling Interaction Map Reveals Basophil Role in Macrophage Imprinting Cell. 2018 Sep 28. pii: S0092-8674(18)31181-4. doi: 10.1016/j.cell.2018.09.009 |
| Baumgartner, C., Toifl, S., Farlik, M., Halbritter, F., Scheicher, R., Fischer, I., Sexl, V., Bock, C. and Baccarini, M. (2018) An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion Cell Stem Cell. 2018 May 17. pii: S1934-5909(18)30221-2. doi: 10.1016/j.stem.2018.05.003 |
| Wingelhofer, B., Maurer, B., Heyes, E.C., Cumaraswamy, A.A., Berger-Becvar, A., de Araujo, E.D., Orlova, A., Freund, P., Ruge, F., Park, J., Tin, G., Ahmar, S., Lardeau, C.H., Sadovnik, I., Bajusz, D., Keseru, G.M., Grebien, F., Kubicek, S., Valent, P., Gunning, P.T., and Moriggl, R. (2018). Pharmacologic inhibition of STAT5 in acute myeloid leukemia. Leukemia 10.1038/s41375-017-0005-9 |
| Schrader, A., Crispatzu, G., Oberbeck, S., Mayer, P., Putzer, S., von Jan, J., Vasyutina, E., Warner, K., Weit, N., Pflug, N., Braun, T., Andersson, E.I., Yadav, B., Riabinska, A., Maurer, B., Ventura Ferreira, M.S., Beier, F., Altmuller, J., Lanasa, M., Herling, C.D., Haferlach, T., Stilgenbauer, S., Hopfinger, G., Peifer, M., Brummendorf, T.H., Nurnberg, P., Elenitoba-Johnson, K.S.J., Zha, S., Hallek, M., Moriggl, R., Reinhardt, H.C., Stern, M.H., Mustjoki, S., Newrzela, S., Frommolt, P., and Herling, M. (2018). Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL. Nat Commun 9, 697 |
| Pham, H.T.T., Maurer, B., Prchal-Murphy, M., Grausenburger, R., Grundschober, E., Javaheri, T., Nivarthi, H., Boersma, A., Kolbe, T., Elabd, M., Halbritter, F., Pencik, J., Kazemi, Z., Grebien, F., Hengstschlager, M., Kenner, L., Kubicek, S., Farlik, M., Bock, C., Valent, P., Muller, M., Rulicke, T., Sexl, V., and Moriggl, R. (2018). STAT5BN642H is a driver mutation for T cell neoplasia. J Clin Invest 128, 387-401 |
| Orlova, A., Wingelhofer, B., Neubauer, H.A., Maurer, B., Berger-Becvar, A., Keseru, G.M., Gunning, P.T., Valent, P., and Moriggl, R. (2018). Emerging therapeutic targets in myeloproliferative neoplasms and peripheral T-cell leukemia and lymphomas. Expert Opin Ther Targets 22, 45-57. doi: 10.1080/14728222.2018.1406924 |
| Glasner, A., Levi, A., Enk, J., Isaacson, B., Viukov, S., Orlanski, S., Scope, A., Neuman, T., Enk, C.D., Hanna, J.H., Sexl, V., Jonjic, S., Seliger, B., Zitvogel, L., and Mandelboim, O. (2018). NKp46 Receptor-Mediated Interferon-gamma Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. Immunity 10.1016/j.immuni.2017.12.007 |
| Crncec, I., Modak, M., Gordziel, C., Svinka, J., Scharf, I., Moritsch, S., Pathria, P., Schlederer, M., Kenner, L., Timelthaler, G., Muller, M., Strobl, B., Casanova, E., Bayer, E., Mohr, T., Stockl, J., Friedrich, K., and Eferl, R. (2018). Stat1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer. Mol Oncol 10.1002/1878-0261.12178 |
2017 Publications
| Mueller, K.M., Hartmann, K., Kaltenecker, D., Vettorazzi, S., Bauer, M., Mauser, L., Amann, S., Jall, S., Fischer, K., Esterbauer, H., Muller, T.D., Tschop, M.H., Magnes, C., Haybaeck, J., Scherer, T., Bordag, N., Tuckermann, J.P., and Moriggl, R. (2017). Adipocyte Glucocorticoid Receptor Deficiency Attenuates Aging- and Hfd-Induced Obesity, and Impairs the Feeding-Fasting Transition. Diabetes 66, 272-286 |
| Maurer, B., Farlik, M., and Sexl, V. (2017). It is a differentiation game: STAT5 in a new role. Cell Death Differ 10.1038/cdd.2017.71, 953-954 |
| Martins, R., and Knapp, S. (2017). Heme and hemolysis in innate immunity: adding insult to injury. Curr Opin Immunol 50, 14-20 |
| Majoros, A., Platanitis, E., Kernbauer-Holzl, E., Rosebrock, F., Muller, M., and Decker, T. (2017). Canonical and Non-Canonical Aspects of JAK-STAT Signaling: Lessons from Interferons for Cytokine Responses. Front Immunol 8, 29 |
| Linke, M., Pham, H.T., Katholnig, K., Schnoller, T., Miller, A., Demel, F., Schutz, B., Rosner, M., Kovacic, B., Sukhbaatar, N., Niederreiter, B., Bluml, S., Kuess, P., Sexl, V., Muller, M., Mikula, M., Weckwerth, W., Haschemi, A., Susani, M., Hengstschlager, M., Gambello, M.J., and Weichhart, T. (2017). Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nat Immunol 10.1038/ni.3655 |
| Keller, A., Wingelhofer, B., Peter, B., Bauer, K., Berger, D., Gamperl, S., Reifinger, M., Cerny-Reiterer, S., Moriggl, R., Willmann, M., Valent, P., and Hadzijusufovic, E. (2017). The JAK2/STAT5 signaling pathway as a potential therapeutic target in canine mastocytoma. Vet Comp Oncol 10.1111/vco.12311 |
| Kaltenecker, D., Mueller, K.M., Benedikt, P., Feiler, U., Themanns, M., Schlederer, M., Kenner, L., Schweiger, M., Haemmerle, G., and Moriggl, R. (2017). Adipocyte STAT5 deficiency promotes adiposity and impairs lipid mobilisation in mice. Diabetologia 60, 296-305 |
| Ghanem, S., Friedbichler, K., Boudot, C., Bourgeais, J., Gouilleux-Gruart, V., Regnier, A., Herault, O., Moriggl, R., and Gouilleux, F. (2017). STAT5A/5B-specific expansion and transformation of hematopoietic stem cells. Blood Cancer J 7, e514 |
| Friedrich, K., Dolznig, H., Han, X., and Moriggl, R. (2017). Steering of carcinoma progression by the YIN/YANG interaction of STAT1/STAT3. Biosci Trends 10.5582/bst.2016.01250 |
| Freund, P., Kerenyi, M.A., Hager, M., Wagner, T., Wingelhofer, B., Pham, H.T., Elabd, M., Han, X., Valent, P., Gouilleux, F., Sexl, V., Kramer, O.H., Groner, B., and Moriggl, R. (2017). O-GlcNAcylation of STAT5 controls tyrosine phosphorylation and oncogenic transcription in STAT5-dependent malignancies. Leukemia 10.1038/leu.2017.4 |
| Fragiadaki, M., Lannoy, M., Themanns, M., Maurer, B., Leonhard, W.N., Peters, D.J., Moriggl, R., and Ong, A.C. (2017). STAT5 drives abnormal proliferation in autosomal dominant polycystic kidney disease. Kidney Int 10.1016/j.kint.2016.10.039 |
| Eigner, K., Filik, Y., Mark, F., Schutz, B., Klambauer, G., Moriggl, R., Hengstschlager, M., Stangl, H., Mikula, M., and Rohrl, C. (2017). The unfolded protein response impacts melanoma progression by enhancing FGF expression and can be antagonized by a chemical chaperone. Sci Rep 7, 17498 |
| Boidol, B., Kornauth, C., van der Kouwe, E., Prutsch, N., Kazianka, L., Gultekin, S., Hoermann, G., Mayerhoefer, M.E., Hopfinger, G., Hauswirth, A., Panny, M., Aretin, M.B., Hilgarth, B., Sperr, W.R., Valent, P., Simonitsch-Klupp, I., Moriggl, R., Merkel, O., Kenner, L., Jager, U., Kubicek, S., and Staber, P.B. (2017). First in human response of BCL-2 inhibitor venetoclax in T-cell prolymphocytic leukemia. Blood 10.1182/blood-2017-05-785683 |
2016 Publications
| Zotz, J.S., Wölbing, F., Lassnig, C., Kauffmann, M., Schulte, U., Kolb, A., Whitelaw, B., Müller, M., Biedermann, T., and Huber, M. (2016). CD13/aminopeptidase N is a negative regulator of mast cell activation. FASEB J 30, 2225-2235 |
| Themanns, M., Mueller, K.M., Kessler, S.M., Golob-Schwarzl, N., Mohr, T., Kaltenecker, D., Bourgeais, J., Paier-Pourani, J., Friedbichler, K., Schneller, D., Schlederer, M., Zebedin-Brandl, E., Terracciano, L.M., Han, X., Kenner, L., Wagner, K.U., Mikulits, W., Kozlov, A.V., Heim, M.H., Gouilleux, F., Haybaeck, J., and Moriggl, R. (2016). Hepatic Deletion of Janus Kinase 2 Counteracts Oxidative Stress in Mice. Sci Rep 6, 34719 |
| Putz, E.M., Majoros, A., Gotthart, D., Prchal-Murphy, M., Zebedin-Brandl, E., Fux, D.A., Schlattl, A., Schreiber, R.D., Carotta, S., Müller, M., Gerner, C., Decker, T., and Sexl, V. (2016). Novel non-canonical role of STAT1 in Natural Killer cell cytotoxicity. OncoImmunology 10.1080/2162402X.2016.1186314. |
| Pencik, J., Pham, H.T., Schmoellerl, J., Javaheri, T., Schlederer, M., Culig, Z., Merkel, O., Moriggl, R., Grebien, F., and Kenner, L. (2016). JAK-STAT signaling in cancer: From cytokines to non-coding genome. Cytokine 10.1016/j.cyto.2016.06.017 |
| Park, J., Kim, S., Joh, J., Remick, S.C., Miller, D.M., Yan, J., Kanaan, Z., Chao, J.H., Krem, M.M., Basu, S.K., Hagiwara, S., Kenner, L., Moriggl, R., Bunting, K.D., and Tse, W. (2016). MLLT11/AF1q boosts oncogenic STAT3 activity through Src-PDGFR tyrosine kinase signaling. Oncotarget 10.18632/oncotarget.9759 |
| Nivarthi, H., Gordziel, C., Themanns, M., Kramer, N., Eberl, M., Rabe, B., Schlederer, M., Rose-John, S., Knosel, T., Kenner, L., Freund, P., Aberger, F., Han, X., Kralovics, R., Dolznig, H., Jennek, S., Friedrich, K., and Moriggl, R. (2016). The ratio of STAT1 to STAT3 expression is a determinant of colorectal cancer growth. Oncotarget 10.18632/oncotarget.9315 |
| Nivarthi, H., Chen, D., Cleary, C., Kubesova, B., Jaeger, R., Bogner, E., Marty, C., Pecquet, C., Vainchenker, W., Constantinescu, S.N., and Kralovics, R. (2016). Thrombopoietin receptor is required for the oncogenic function of CALR mutants. Leukemia 10.1038/leu.2016.32 |
| Milosevic Feenstra, J.D., Nivarthi, H., Gisslinger, H., Leroy, E., Rumi, E., Chachoua, I., Bagienski, K., Kubesova, B., Pietra, D., Gisslinger, B., Milanesi, C., Jager, R., Chen, D., Berg, T., Schalling, M., Schuster, M., Bock, C., Constantinescu, S.N., Cazzola, M., and Kralovics, R. (2016). Whole exome sequencing identifies novel MPL and JAK2 mutations in triple negative myeloproliferative neoplasms. Blood 127, 325-332 |
| Marty, C., Pecquet, C., Nivarthi, H., El-Khoury, M., Chachoua, I., Tulliez, M., Villeval, J.L., Raslova, H., Kralovics, R., Constantinescu, S.N., Plo, I., and Vainchenker, W. (2016). Calreticulin mutants in mice induce an MPL-dependent thrombocytosis with frequent progression to myelofibrosis. Blood 127, 1317-1324 |
| Majoros, A., Platanitis, E., Szappanos, D., Cheoan, H.J., Vogl, C., Shukla, P., Stark, G.R., Sexl, V., Schreiber, R.D., Schindler, C., Müller, M., and Decker, T. (2016). Response to interferons and antibacterial innate immunity in absence of tyrosine-phosphorylated STAT1. EMBO Rep 17, 367-382 |
| Maier, B.B., Hladik, A., Lakovits, K., Korosec, A., Martins, R., Kral, J.B., Mesteri, I., Strobl, B., Muller, M., Kalinke, U., Merad, M., and Knapp, S. (2016). Type I interferon promotes alveolar epithelial type II cell survival during pulmonary S. pneumoniae infection and sterile lung injury in mice. European journal of immunology 10.1002/eji.201546201 |
| Klose, R., Krzywinska, E., Castells, M., Gotthardt, D., Putz, E.M., Kantari-Mimoun, C., Chikdene, N., Meinecke, A.K., Schrodter, K., Helfrich, I., Fandrey, J., Sexl, V., and Stockmann, C. (2016). Targeting VEGF-A in myeloid cells enhances natural killer cell responses to chemotherapy and ameliorates cachexia. Nat Commun 7, 12528 |
| Javaheri, T., Kazemi, Z., Pencik, J., Pham, H.T., Kauer, M., Noorizadeh, R., Sax, B., Nivarthi, H., Schlederer, M., Maurer, B., Hofbauer, M., Aryee, D.N., Wiedner, M., Tomazou, E.M., Logan, M., Hartmann, C., Tuckermann, J.P., Kenner, L., Mikula, M., Dolznig, H., Uren, A., Richter, G.H., Grebien, F., Kovar, H., and Moriggl, R. (2016). Increased survival and cell cycle progression pathways are required for EWS/FLI1-induced malignant transformation. Cell Death Dis 7, e2419 |
| Harutyunyan, A.S., Giambruno, R., Krendl, C., Stukalov, A., Klampfl, T., Berg, T., Chen, D., Milosevic Feenstra, J.D., Jager, R., Gisslinger, B., Gisslinger, H., Rumi, E., Passamonti, F., Pietra, D., Muller, A.C., Parapatics, K., Breitwieser, F.P., Herrmann, R., Colinge, J., Bennett, K.L., Superti-Furga, G., Cazzola, M., Hammond, E., and Kralovics, R. (2016). Germline RBBP6 mutations in familial myeloproliferative neoplasms. Blood 127, 362-365 |
| Gotthardt, D., Putz, E.M., Grundschober, E., Prchal-Murphy, M., Straka, E., Kudweis, P., Heller, G., Bago-Horvath, Z., Witalisz-Siepracka, A., Cumaraswamy, A.A., Gunning, P.T., Strobl, B., Muller, M., Moriggl, R., Stockmann, C., and Sexl, V. (2016). STAT5 is a key regulator in NK cells and acts as molecular switch from tumor surveillance to tumor promotion. Cancer discovery 6, 414-429 |
| Floss, D.M., Klocker, T., Schroder, J., Lamertz, L., Mrotzek, S., Strobl, B., Hermanns, H., and Scheller, J. (2016). Defining the functional binding sites of Interleukin 12 receptor beta1 and Interleukin 23 receptor to Janus kinases. Molecular biology of the cell 27, 2301-2316 |
| Decker, T. (2016). Emancipation from transcriptional latency: unphosphorylated STAT5 as guardian of hematopoietic differentiation. The EMBO journal 35, 555-557 |
| Chachoua, I., Pecquet, C., El-Khoury, M., Nivarthi, H., Albu, R.I., Marty, C., Gryshkova, V., Defour, J.P., Vertenoeil, G., Ngo, A., Koay, A., Raslova, H., Courtoy, P.J., Choong, M.L., Plo, I., Vainchenker, W., Kralovics, R., and Constantinescu, S.N. (2016). Thrombopoietin receptor activation by myeloproliferative neoplasm associated calreticulin mutants. Blood 127, 1325-1335 |
| Castiglia, V., Piersigilli, A., Ebner, F., Janos, M., Goldmann, O., Dambock, U., Kroger, A., Weiss, S., Knapp, S., Jamieson, A.M., Kirschning, C., Kalinke, U., Strobl, B., Muller, M., Stoiber, D., Lienenklaus, S., and Kovarik, P. (2016). Type I Interferon Signaling Prevents IL-1beta-Driven Lethal Systemic Hyperinflammation during Invasive Bacterial Infection of Soft Tissue. Cell Host Microbe 19, 375-387 |
| Bourgeais, J., Ishac, N., Medrzycki, M., Brachet-Botineau, M., Desbourdes, L., Gouilleux-Gruart, V., Pecnard, E., Rouleux-Bonnin, F., Gyan, E., Domenech, J., Mazurier, F., Moriggl, R., Bunting, K.D., Herault, O., and Gouilleux, F. (2016). Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses. Oncotarget 10.18632/oncotarget.11480 |
| Bottos, A., Gotthardt, D., Gill, J.W., Gattelli, A., Frei, A., Tzankov, A., Sexl, V., Wodnar-Filipowicz, A., and Hynes, N.E. (2016). Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models. Nat Commun 7, 12258. |
| Balligand, T., Achouri, Y., Pecquet, C., Chachoua, I., Nivarthi, H., Marty, C., Vainchenker, W., Plo, I., Kralovics, R., and Constantinescu, S.N. (2016). Pathologic activation of thrombopoietin receptor and JAK2-STAT5 pathway by frameshift mutants of mouse calreticulin. Leukemia 10.1038/leu.2016.47 |
2015 Publications
| Shukla, P., Vogl, C., Wallner, B., Rigler, D., Müller, M., and Macho-Maschler, S. (2015). High-Throughput mRNA and miRNA Profiling of Epithelial-Mesenchymal Transition in MDCK cells. BMC Genomics 16, 944 |
| Minas, T.Z., Han, J., Javaheri, T., Hong, S.H., Schlederer, M., Saygideger-Kont, Y., Celik, H., Mueller, K.M., Temel, I., Ozdemirli, M., Kovar, H., Erkizan, H.V., Toretsky, J., Kenner, L., Moriggl, R., and Uren, A. (2015). YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. Oncotarget 6, 37678-37694 |
| Leopold Wager, C.M., Hole, C.R., Wozniak, K.L., Olszewski, M.A., Mueller, M., and Wormley, F.L., Jr. (2015). STAT1 Signaling within Macrophages is Required for Anti-fungal Activity against Cryptococcus neoformans. . Infection and immunity 10.1128/IAI.00935-15. |
| Leitner, N.R., Witalisz-Siepracka, A., Strobl, B., and Muller, M. (2015). Tyrosine kinase 2 - Surveillant of tumours and bona fide oncogene. Cytokine 10.1016/j.cyto.2015.10.015 |
| Hainzl, E., Stockinger, S., Rauch, I., Heider, S., Berry, D., Lassnig, C., Schwab, C., Rosebrock, F., Milinovich, G., Schlederer, M., Wagner, M., Schleper, C., Loy, A., Urich, T., Kenner, L., Han, X., Decker, T., Strobl, B., and Muller, M. (2015). Intestinal Epithelial Cell Tyrosine Kinase 2 Transduces IL-22 Signals To Protect from Acute Colitis. Journal of immunology 195, 5011-5024. Journal of immunology 195, 5011-5024 |
| Berry, D., Kuzyk, O., Rauch, I., Heider, S., Schwab, C., Hainzl, E., Decker, T., Müller, M., Strobl, B., Schleper, C., Urich, T., Wagner, M., Kenner, L., and Loy, A. (2015). Intestinal microbiota signatures associated with inflammation history in mice experiencing recurring colitis Front Microbiol. 2015; 6: 1408. doi: 10.3389/fmicb.2015.01408 |
| Them, N.C., Bagienski, K., Berg, T., Gisslinger, B., Schalling, M., Chen, D., Buxhofer-Ausch, V., Thaler, J., Schloegl, E., Gastl, G.A., Wolf, D., Strecker, K., Egle, A., Melchardt, T., Burgstaller, S., Willenbacher, E., Zagrijtschuk, O., Klade, C., Greil, R., Gisslinger, H., and Kralovics, R. (2015). Molecular responses and chromosomal aberrations in patients with polycythemia vera treated with peg-proline-interferon alpha-2b. Am J Hematol 90: 288-294 doi: 10.1002/ajh.23928 |
| Bauer, E., Witalisz, A., Strobl, B., and Stoiber, D. (2015). Methods to study tumor surveillance using tumor cell transplantation into genetically engineered mice. Methods Mol Biol 1267: 439-456. [review] doi: 10.1007/978-1-4939-2297-0_22 |
| Wiesauer, I., Gaumannmuller, C., Steinparzer, I., Strobl, B., and Kovarik§, P. (2015). §SFB member of the 1st funding period Promoter occupancy of STAT1 in interferon responses is regulated by processive transcription. Mol Cell Biol 35: 716-727. doi: 10.1128/MCB.01097-14 |
| Schneckenleithner, C., Hoelbl-Kovacic, A., and Sexl, V. (2015). Modeling BCR/ABL-Driven Malignancies in the Mouse. Methods in Mol Biol 1267: 263-282. [review] doi: 10.1007/978-1-4939-2297-0_12 |
| Ustun, S., Lassnig, C., Preitschopf, A., Mikula, M., Müller, M., Hengstschlager, M., and Weichhart, T. (2015). Effects of the mTOR inhibitor everolimus and the PI3K/mTOR inhibitor NVP-BEZ235 in murine acute lung injury models. Transplant immunology. [Epub ahead of print] doi: 10.1016/j.trim.2015.06.001 |
| Stiedl, P., McMahon, R., Blaas, L., Stanek, V., Svinka, J., Grabner, B., Zollner, G., Kessler, S.M., Claudel, T., Müller, M., Mikulits§, W., Bilban, M., Esterbauer, H., Eferl§, R., Haybaeck, J., Trauner, M., and Casanova, E. (2015). §SFB member of the 1st and 2nd funding period Growth hormone resistance exacerbates cholestasis-induced murine liver fibrosis. Hepatology 61: 613-626. doi: 10.1002/hep.27408 |
| Park, J., Schlederer, M., Schreiber, M., Ice, R., Merkel, O., Bilban, M., Hofbauer, S., Kim, S., Addison, J., Zou, J., Ji, C., Bunting, S.T., Wang, Z., Shoham, M., Huang, G., Bago-Horvath, Z., Gibson, L.F., Rojanasakul, Y., Remick, S., Ivanov, A., Pugacheva, E., Bunting, K.D., Moriggl, R., Kenner, L., and Tse, W. (2015). AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. Oncotarget. Online ISSN: 1949-2553 |
| Merkel, O., Hamacher, F., Griessl, R., Grabner, L., Schiefer, A.I., Prutsch, N., Baer, C., Egger, G., Schlederer, M., William Krenn, P., Nicole Hartmann, T., Simonitsch-Klupp, I., Plass, C., Staber, P., Moriggl, R., Turner, S.D., Greil, R., and Kenner, L. (2015). Oncogenic role of miR-155 in anaplastic large cell lymphoma lacking the t(2;5) translocation. J Pathol Mar 26. [Epub ahead of print] doi: 10.1002/path.4539 |
| Girardot, M., Pecquet, C., Chachoua, I., Van Hees, J., Guibert, S., Ferrant, A., Knoops, L., Baxter, E.J., Beer, P.A., Giraudier, S., Moriggl, R., Vainchenker, W., Green, A.R., and Constantinescu, S.N. (2015). Persistent STAT5 activation in myeloid neoplasms recruits p53 into gene regulation. Oncogene 34:1323-1332. doi: 10.1038/onc.2014.60 |
| Schutz, A., Roser, K., Klitzsch, J., Lieder, F., Aberger, F., Gruber, W., Mueller, K.M., Pupyshev, A., Moriggl, R., and Friedrich, K. (2015). Lung Adenocarcinomas and Lung Cancer Cell Lines Show Association of MMP-1 Expression With STAT3 Activation. Transl Oncol 8: 97-105. doi: dx.doi.org/10.1016/j.tranon.2015.02.002 |
| Pencik, J., Schlederer, M., Gruber, W., Unger, C., Walker, S.M., Chalaris, A., Marié, I.J., Hassler, M.R., Javaheri, T., Aksoy, O., Blayney, J.K., Prutsch, N., Skucha, A., Herac, M., Krämer, O.H., Mazal, P., Grebien, F., Egger, G., Poli, V., Mikulits§, W., Eferl§, R., Esterbauer, H., Kennedy, R., Fend, F., Scharpf, M., Braun, M., Perner, S., Levy, D.E., Malcolm, T., Turner, S.D., Haitel, A., Susani, M., Moazzami, A., Rose-John, S., Aberger, F., Merkel, O., Moriggl, R., Culig, Z., Dolznig, H., and Kenner, L. (2015). §SFB member of the 1st and 2nd funding period STAT3 regulated ARF expression suppresses prostate cancer metastasis. Nat Commun. 6:7736. doi: 10.1038/ncomms8736 |
| Abdul-Sater, A.A., Majoros, A., Plumlee, C.R., Perry, S., Gu, A.D., Lee, C., Shresta, S., Decker, T., and Schindler, C. (2015). Different STAT Transcription Complexes Drive Early and Delayed Responses to Type I IFNs. J Immunol May 27. pii: 1401139. [Epub ahead of print] doi: 10.4049/jimmunol.1401139 |
| Bakiri, L., Macho-Maschler, S., Custic, I., Niemiec, J., Guio-Carrion, A., Hasenfuss, S.C., Eger, A., Müller, M., Beug, H., and Wagner, E.F. (2015). 1945-2011, SFB member of the 1st funding period; associated with coordination project Fra-1/AP-1 induces mammary epithelial cell EMT by modulating Zeb1/2 and TGFbeta expression. Cell Death Differ 22: 336-350. doi: 10.1038/cdd.2014.157 |
| Wienerroither, S., Shukla, P., Farlik, M., Majoros, A., Stych, B., Vogl, C., Cheon, H., Stark, G.R., Strobl, B., Müller, M., and Decker, T. (2015). Cooperative transcriptional activation of antimicrobial genes by STAT and NF?B pathways through concerted recruitment of the mediator complex. Cell Reports 12: 1-13. doi: http://dx.doi.org/10.1016/j.celrep.2015.06.021 |
| Rauch, I., Rosebrock, F., Hainzl, E., Heider, S., Majoros, A., Wienerroither, S., Strobl, B., Stockinger, S., Müller, M., Kenner, L., and Decker, T. (2015). Noncanonical effects of IRF9 in intestinal inflammation: more than type I and type III interferons. Mol Cell Biol 35: 2332-2343 doi: 10.1128/MCB.01498-14 |
| Prchal-Murphy, M., Witalisz-Siepracka, A., Bednarik, K.T., Putz, E.M., Gotthardt, D., Meissl, K., Sexl, V., Müller, M., and Strobl, B. (2015). In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity. Oncoimmunology. doi: 10.1080/2162402X.2015.1047579 |
| Pathria*, P., Gotthardt*, D., Prchal-Murphy*, M., Putz*, E.M., Holcmann, M., Schlederer, M., Grabner, B., Crncec, I., Svinka, J., Musteanu, M., Hoffmann, T., Filipits, M., Berger, W., Poli, V., Kenner, L., Bilban, M., Casanova, E., Müller, M., Strobl, B., Bayer, E., Mohr, T., Sexl, V., and Eferl§, R. (2015). *equal contribution §SFB member of the 1st and 2nd funding period Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice. Oncoimmunology 4(4):e998529. doi: 10.1080/2162402X.2014.998529 |
| Nivarthi, H., Prchal-Murphy, M., Swoboda, A., Hager, M., Schlederer, M., Kenner, L., Tuckermann, J., Sexl, V., Moriggl, R., and Ermakova, O. (2015). Stat5 gene dosage in T cells modulates CD8 T cell homeostasis and attenuates contact hypersensitivity response in mice. Allergy 70: 67-79. doi: 10.1111/all.12535 |
| Gilbert*, S., Nivarthi*, H., Mayhew*, C.N., Lo, Y.H., Noah, T.K., Vallance, J., Rulicke, T., Müller, M., Jegga, A.G., Tang, W., Zhang, D., Helmrath, M., Shroyer, N., Moriggl, R., and Han, X. (2015). *equal contribution Activated STAT5 Confers Resistance to Intestinal Injury by Increasing Intestinal Stem Cell Proliferation and Regeneration. Stem Cell Rep 4: 209-225. doi: 10.1016/j.stemcr.2014.12.004 |
2014 Publications
| Jager, R., Harutyunyan, A.S., Rumi, E., Pietra, D., Berg, T., Olcaydu, D., Houlston, R.S., Cazzola, M., and Kralovics, R. (2014). Common germline variation at the TERT locus contributes to familial clustering of myeloproliferative neoplasms. Am J Hematol 89: 1107-1110. doi: 10.1002/ajh.23842 |
| Klose, C.S., Flach, M., Mohle, L., Rogell, L., Hoyler, T., Ebert, K., Fabiunke, C., Pfeifer, D., Sexl, V., Fonseca-Pereira, D., Domingues, R.G., Veiga-Fernandes, H., Arnold, S.J., Busslinger, M., Dunay, I.R., Tanriver, Y., and Diefenbach, A. (2014). Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages. Cell 157: 340-356. |
| Putz, E.M., Hoelzl, M.A., Baeck, J., Bago-Horvath, Z., Schuster, C., Reichholf, B., Kern, D., Aberger, F., Sexl, V., and Hoelbl-Kovacic, A. (2014). Loss of STAT3 in Lymphoma Relaxes NK Cell-Mediated Tumor Surveillance. Cancers 6: 193-210. doi: 10.3390/cancers6010193 |
| Grundschober, E., Hoelbl-Kovacic, A., Bhagwat, N., Kovacic, B., Scheicher, R., Eckelhart, E., Kollmann, K., Keller, M., Grebien, F., Wagner, K.U., Levine, R.L., and Sexl, V. (2014). Acceleration of Bcr-Abl leukemia induced by deletion of JAK2. Leukemia 28: 1918-1922. doi: 10.1038/leu.2014.152 |
| Gotthardt, D., Prchal-Murphy, M., Seillet, C., Glasner, A., Mandelboim, O., Carotta, S., Sexl, V., and Putz, E.M. (2014). NK cell development in bone marrow and liver: site matters. Genes Immun 15: 584-587. doi: 10.1038/gene.2014.55 |
| Bibi, S., Arslanhan, M.D., Langenfeld, F., Jeanningros, S., Cerny-Reiterer, S., Hadzijusufovic, E., Tchertanov, L., Moriggl, R., Valent, P., and Arock, M. (2014). Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy. Haematologica 99: 417-429. [review] doi: 10.3324/haematol.2013.098442 |
| Schlederer, M., Mueller, K.M., Haybaeck, J., Heider, S., Huttary, N., Rosner, M., Hengstschlager, M., Moriggl, R., Dolznig, H., and Kenner, L. (2014). Reliable Quantification of Protein Expression and Cellular Localization in Histological Sections. PLoS One 9: e100822. doi: 10.1371/journal.pone.0100822 |
| Begitt, A., Droescher, M., Meyer, T., Schmid, C.D., Baker, M., Antunes, F., Owen, M.R., Naumann, R., Decker, T., and Vinkemeier, U. (2014). STAT1-cooperative DNA binding distinguishes type-1 from type-2 interferon signaling. Nat Immunol 15: 168-176. doi: 10.1038/ni.2794 |
| Csiszar, A., Kutay, B., Wirth, S., Schmidt, U., Macho-Maschler, S., Schreiber, M., Alacakaptan, M., Vogel, G.F., Aumayr, K., Huber, L.A., and Beug, H. (2014). 1945-2011, SFB member of the 1st funding period; associated with coordination project Interleukin-like epithelial-to-mesenchymal transition inducer activity is controlled by proteolytic processing and plasminogen inverted question mark urokinase plasminogen activator receptor system-regulated secretion during breast cancer progression. Breast Cancer Res 16: 433. doi: 10.1186/s13058-014-0433-7 |
| Strobl, B., and Moriggl, R. (2014). Editorial: Recovery from chemotherapy depends on STAT1 for replenishment of B lymphopoiesis. J Leukocyte Biol 95: 849-851. [editorial review] doi: 10.1189/jlb.0114051 |
| Wienerroither, S., Rauch, I., Rosebrock, F., Jamieson, A.M., Bradner, J., Muhar, M., Zuber, J., Müller, M., and Decker, T. (2014). Regulation of NO synthesis, local inflammation and innate immunity to pathogens by BET family proteins. Mol Cell Biol 34: 415-427. doi: 10.1128/MCB.01353-13 |
| Vielnascher, R.M., Hainzl, E., Leitner, N.R., Rammerstorfer, M., Popp, D., Witalisz, A., Rom, R., Karaghiosoff, M., Kolbe, T., Müller, S., Rülicke, T., Lassnig, C., Strobl, B., and Müller, M. (2014). Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance. Transgenic Res. 23: 519-529. doi: 10.1007/s11248-014-9795-y |
| Semper, C., Leitner, N.R., Lassnig, C., Parrini, M., Mahlakoiv, T., Rammerstorfer, M., Lorenz, K., Rigler, D., Müller, S., Kolbe, T., Vogl, C., Rülicke, T., Staeheli, P., Decker, T., Müller, M., and Strobl, B. (2014). STAT1? is not dominant negative and is capable of contributing to IFN?-dependent innate immunity. Mol Cell Biol 34: 2235-2248. doi: 10.1128/MCB.00295-14 |
| Liehl, P., Zuzarte-Luís, V., Chan, J., Zillinger, T., Baptista, F., Carapau, D., Konert, M., Hanson, K.K., Carret, C., Lassnig, C., Müller, M., Kalinke, U., Saeed, M., Ferreira Chora, A., Golenbock, D.T., Strobl, B., Prudencio, M., Coelho, L.P., Kappe, S.H., Superti-Furga, J., Pichlmair, A., Vigário, A.M., Rice, C.M., Fitzgerald, K.A., Barchert, W., and Mota, M.M. (2014). Host-cell sensors for Plasmodium activate innate immunity against liver-stage infection. Nat Med 20: 47-53. doi: 10.1038/nm.342 |
| Leitner, N.R., Lassnig, C., Rom, R., Heider, S., Bago-Horvath, Z., Eferl§, R., Müller, S., Kolbe, T., Kenner, L., Rülicke, T., Strobl, B., and Müller, M. (2014). §SFB member of the 1st and 2nd funding period Inducible, dose-adjustable and time-restricted reconstitution of Stat1 deficiency in vivo. PLoS One 9: e86608. doi: 10.1371/journal.pone.0086608 |
| Kovacic, B., Hoelbl-Kovacic, A., Fischhuber, K.M., Leitner, N.R., Gotthardt, D., Casanova, E., Sexl, V., and Müller, M. (2014). Lactotransferrin-Cre reporter mice trace neutrophils, monocytes/macrophages and distinct subtypes of dendritic cells. Haematologica 99: 1006-1015. doi: 10.3324/haematol.2013.097154 |
| Keil, E., Finkenstädt, D., Wufka, C., Trilling, M., Liebfried, P., Strobl, B., Müller, M., and Pfeffer, K. (2014). Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation loop mutation. Blood 123: 520-529. doi: http://dx.doi.org/10.1182/blood-2013-03-492157 |
| Grunert, T., Monahan, A., Lassnig, C., Vogl, C., Strobl, B., Müller, M., and Ehling-Schulz, M. (2014). Deciphering host genotype-specific impacts on the metabolic fingerprint of Listeria monocytogenes by FTIR spectroscopy. PLoS One 9: e115959. doi: 10.1371/journal.pone.0115959 |
| Gotthardt, D., Putz, E.M., Straka, E., Kudweis, P., Biaggio, M., Poli, V., Strobl, B., Müller, M., and Sexl, V. (2014). Loss of STAT3 in murine NK cells enhances NK cell-dependent tumor surveillance. Blood 124: 2370-2379. doi: http://dx.doi.org/10.1182/blood-2014-03-564450 |
| Bosmann, M., Strobl, B., Kichler, N., Pache, F., Murray, P.J., Müller, M., and Ward, P.A. (2014). Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. J Leukoc Biol. 96: 123-131. doi: 10.1189/jlb.3A1013-541R |
| Bosmann, M., Russkamp, N.F., Strobl, B., Roewe, J., Balouzian, L., Pache, F., Radsak, M.P., van Rooijen, N., Zetoune, F.S., Sarma, J.V., Núnez, G., Müller, M., Murray, P.J., and Ward, P.A. (2014). Interruption of macrophage-derived IL-27(p28) production by IL-10 during sepsis requires STAT3 but not SOCS3. J Immunol 193: 5668-5677. doi: 10.4049/jimmunol.1302280 |
| Berger, A., Sexl, V., Valent, P., and Moriggl, R. (2014). Inhibition of STAT5: A therapeutic option in BCR-ABL1-driven leukemia. Oncotarget 5: 9564-9576. Online ISSN: 1949-2553 |
| Berger*, A., Hoelbl-Kovacic*, A., Bourgeais, J., Hoefling, L., Warsch, W., Grundschober, E., Uras, I.Z., Menzl, I., Putz, E.M., Hoermann, G., Schuster, C., Fajmann, S., Leitner, E., Kubicek, S., Moriggl, R., Gouilleux, F., and Sexl, V. (2014). *equal contribution PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis. Leukemia 28: 629-641. doi: 10.1038/leu.2013.351 |
2013 Publications
| Koromilas, A.E., and Sexl, V. (2013). The tumor suppressor function of STAT1 in breast cancer. JAK-STAT 2:2, 1-5. [review] doi: 10.4161/jkst.23353 |
| Warsch, W., Walz, C., and Sexl, V. (2013). JAK of all trades: JAK2-STAT5 as novel therapeutic targets in BCR-ABL1+ chronic myeloid leukemia. Blood 122: 2167-2175. doi: dx.doi.org/10.1182/blood-2013-02-485573 |
| Warsch, W., Grundschober, E., and Sexl, V. (2013). Adding a new facet to STAT5 in CML: Multitasking for leukemic cells. Cell Cycle 12: 1813-1814. [editorial feature] doi: 10.4161/cc.25116 |
| Richter, K., Perriard, G., Behrendt, R., Schwendener, R.A., Sexl, V., Dunn, R., Kamanaka, M., Flavell, R.A., Roers, A., and Oxenius, A. (2013). Macrophage and T cell produced IL-10 promotes vrial chronicity. PLoS Pathog 9: e1003735. doi: 10.1371/journal.ppat.1003735 |
| Kantner*, H.P., Warsch*, W., Delogu, A., Bauer, E., Esterbauer, H., Casanova, E., Sexl, V., and Stoiber, D. (2013). *equal contribution ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells. Neoplasia 15: 1292-1300. doi: 10.1593/neo.131310 |
| Hannesdottir, L., Tymoszuk, P., Parajuli, N., Wasmer, M.H., Philipp, S., Daschil, N., Datta, S., Koller, J.B., Tripp, C.H., Stoitzner, P., Muller-Holzner, E., Wiegers, G.J., Sexl, V., Villunger, A., and Doppler, W. (2013). Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response. Eur J Immunol. 43: 2718-2729. doi: 10.1002/eji.201242505 |
| Katholnig, K., Kaltenecker, C.C., Hayakawa, H., Rosner, M., Lassnig, C., Zlabinger, G.J., Gaesetl, M., Müller, M., Hengstschläger, M., Hörl, W.H., Park, J.-M., Säemann, M.D., and Weichart, T. (2013). p38? Senses Environmental Stress To Control Innate Immune Responses via Mechanistic Target of Rapamycin. J Immunol 190: 1519-1527. doi: 10.4049/jimmunol.1202683 |
| McGuckin, C.P., Jurga, M., Miller, A.M., Sarnowska, A., Wiedner, M., Boyle, N.T., Lynch, M.A., Jablonska, A., Drela, K., Lukomska, B., Domanska-Janik, K., Kenner, L., Moriggl, R., Degoul, O., Perruisseau-Carrier, C., and Forraz, N. (2013). Ischemic brain injury: a consortium analysis of key factors involved in mesenchymal stem cell-mediated inflammatory reduction. Arch Biochem Biophys. 534: 88-97. doi: 10.1016/j.abb.2013.02.005 |
| Gordziel, C., Bratsch, J., Moriggl, R., Knosel, T. and Friedrich. K. (2013). Both STAT1 and STAT3 are favourable prognostic determinants in colorectal carcinoma. Br J Cancer 109: 138-146. doi: 10.1038/bjc.2013.274 |
| Chatain, N., Ziegler, P., Fahrenkamp, D., Jost, E., Moriggl, R., Schmitz-Van de Leur, H., and Müller-Newen, G. (2013). Scr family kinases mediate cytoplasmic retention of activated STAT5 in BCR-ABL-positive cells. Oncogene 32: 3587-3597. doi: 10.1038/onc.2012.369 |
| Bancerek, J., Poss, Z.C., Steinparzer, I., Sedlyarov, V., Pfaffenwimmer, T., Mikulic, I., Dölken, L., Strobl, B., Müller, M., Taatjes, D.J., and Kovarik§, P. (2013). §SFB member of the 1st funding period CDK8 kinase phosphorylates transcription factor STAT1 to selectively regulate the interferon response. Immunity 38: 250-262. doi: 10.1016/j.immuni.2012.10.017 |
| Warszawska, J.M., Gawish, R., Sharif, O., Sigel, S., Doninger, B., Lakovits, K., Mesteri, I., Nairz, M., Boon, L., Spiel, A., Fuhrmann, V., Strobl, B., Müller, M., Schenk, P., Weiss, G., and Knapp, S. (2013). Lipocalin 2 deactivates macrophages and worsens pneumococcal pneumonia outcomes. J Clin Invest 123: 3363-3372. doi: 10.1172/JCI67911 |
| Sanda, T., Tyner, J.W., Gutierrez, A., Ngo, V.N., Glover, J., Chang, B.H., Yost, A., Ma, W., Fleischman, A.G., Zhou, W., Yang, Y., Kleppe, M., Ahn, Y., Tatarek, J., Kelliher, M., Neuberg, D., Levine, R.L., Moriggl, R., Müller, M., Gray, N.S., Jamieson, C.H., Weng, A.P., Staudt, L.M., Druker, B.J., and Look, A.T. (2013). TYK2-STAT1-BCL2 Pathway Dependence in T-Cell Acute Lymphoblastic Leukemia. Cancer Discov 3: 564-577. doi: 10.1158/2159-8290.CD-12-0504 |
| Putz, E.M., Gotthardt, D., Hoermann, G., Csiszar, A., Wirth, S., Berger, A., Straka, E., Rigler, D., Wallner, B., Jamieson, A.M., Pickl, W.F., Zebedin-Brandl, E.M., Müller, M., Decker, T., and Sexl, V. (2013). CDK8-Mediated STAT1-S727 Phosphorylation Restrains NK Cell Cytotoxicity and Tumor Surveillance. Cell Rep 15: 437-444. doi: 10.1016/j.celrep.2013.07.012 |
| Köprülü, A.D., Kastner, R., Wienerroither, S., Lassnig, C., Putz, E.-M., Majer, O., Reutterer, B., Sexl, V., Kuchler, K., Müller, M., Decker, T., and Ellmeier, W. (2013). The tyrosine kinase Btk regulates the macrophage response to Listeria monocytogenes infection. PLoS One 8: e60476. doi: 10.1371/journal.pone.0060476 |
| Kollmann, K., Heller, G., Schneckenleitner, C., Warsch, W., Scheicher, R., Ott, R.G., Schäfer, M., Fajmann, S., Schlederer, M., Schiefer, A.-I., Reichart, U., Mayerhofer, M., Hoeller, C., Zöchbauer-Müller, S., Kerjaschki, D., Bock, C., LKenner, L., Hoefler, G., Freissmuth, M., Green, A.R., Moriggl, R., Busslinger, M., Malumbres, M., and Sexl, V. (2013). A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis. Cancer Cell 24: 167-181. doi: dx.doi.org/10.1016/j.ccr.2013.07.012 |
| Kernbauer*, E., Maier*, V., Rauch, I., Müller, M. and Decker, T. (2013). *equal contribution Route of infection determines the impact of type I interferons on innate immunity to Listeria monocytogenes. PLoS One 8: e65007. doi: 10.1371/journal.pone.0065007 |
| Rauch, I., Müller, M., and Decker, T. (2013). The regulation of inflammation by interferons and their STATs. JAK-STAT 2:1, e23820. [review] doi: 10.4161/jkst.23820 |
2012 Publications
| Putz, E.M., Zebedin, E., and Sexl, V. (2012). STAT Transcription Factors: Controlling All Aspects of NK Cell Biology. In Jak-Stat Signaling: From Basics to Disease (Decker, T. and Müller, M., Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 187-204. [book chapter] doi: 10.1007/978-3-7091-0891-8_12 ISBN: 978-3-7091-0890-1 |
| Hantschel*, O., Warsch*, W., Eckelhart, E., Kaupe, I., Grebien, F., Wagner, K.U., Superti-Furga, G., and Sexl, V. (2012). *equal contribution BCR-ABL uncouples canonical JAK2-STAT5 signaling in chronic myeloid leukemia. Nat Chem Biol 8: 285-293. doi: 10.1038/nchembio.775 |
| Strobl, B., Leitner, N.R., and Müller, M. (2012). Multifaceted Antiviral Actions of Interferon-Stimulated Gene Products. In Jak-Stat Signaling: From Basics to Disease. (Decker, T. and Müller, M., Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 387-424. [book chapter] doi: 10.1007/978-3-7091-0891-8_21 ISBN: 978-3-7091-0890-1 |
| Majer, O., Bourgeois, C., Zwolanek, F., Lassnig, C., Kerjaschiki, D., Mack, M., Müller, M., and Kuchler, K. (2012). Type I Interferons Promote Fatal Immunopathology by Regulating Inflammatory Monocytes and Neutrophils during Candida Infections. PLoS Pathog 8: e1002811. doi: 10.1371/journal.ppat.1002811 |
| Derecka, M., Gornicka, A., Koralov, S.B., Szczepanek, K., Morgan, M., Raje, V., Sisler, J., Zhang, Q., Otero, D., Cichy, J., Rajewsky, K., Shimoda, K., Poli, V., Strobl, B., Pellegini, S., Harris, T.E., Seale, P., Russell, A.P., McAinch, A.J., O'Brien, P.E., Keller, S., Croniger, C.M., Kordula, T., and Larner, A.C. (2012). Tyk2 and Stat3 Regulate Brown Adipose Tissue Differentiation and Obesity. Cell Metab 16: 814-824. doi: 10.1016/j.cmet.2012.11.005 |
| Mueller, K.M., Themanns, M., Friedbichler, K., Kornfeld, J.W., Esterbauer, H., Tuckermann, J.P., and Moriggl, R. (2012). Hepatic growth hormone and glucocorticoid receptor signaling in body growth, steatosis and metabolic liver cancer development. Mol Cell Endocrinol 361: 1-11. [review] doi: 10.1016/j.mce.2012.03.026 |
| Nivarthi, H., Friedbichler, K., and Moriggl, R. (2012). Stat5 as a Hematopoietic Master Regulator for Differentiation and Neoplasia Development. In Jak-Stat Signaling: From Basics to Disease. (Decker, T. and Müller, M., Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 153-168. [book chapter] doi: 10.1007/978-3-7091-0891-8_10 ISBN: 978-3-7091-0890-1 |
| Gilbert, S., Zhang, R., Denson, L., Moriggl, R., Steinbrecher, K., Shroyer, N., Lin, J., and Han, X. (2012). Enterocyte STAT5 promotes mucosal wound healing via suppression of myosin light chain kinase-mediated loss of barrier function and inflammation. EMBO Mol Med 4: 109-124. doi: 10.1002/emmm.201100192 |
| Jamieson, A., Farlik, M., and Decker, T. (2012). How Stats Interact with the Molecular Machinery of Transcriptional Activation. In Jak-Stat Signaling: From Basics to Disease. (Decker, T. and Müller, M., Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 65-90. [book chapter] doi: 10.1007/978-3-7091-0891-8_5 ISBN: 978-3-7091-0890-1 |
| Farlik, M., Rapp, B., Marie, I., Levy, D.E., Jamieson, A.M., and Decker, T. (2012). Contribution of a TBK1-IRF7 pathway to IFN-gamma-induced gene expression. Mol Cell Biol 32: 1032-1043 doi: 10.1128/MCB.06021-11 |
| Aubry*, C., Corrd*, S., Wienerroither*, S., Goulard, C., Jones, R., Jamieson, A., Decker, T., O'Neill, T., Dussurget, O. and P. Cossart (2012). *equal contribution A TLR2, TLR3 and TRIF-dependent interferon-? response to bacterial infection. PLoS One 7: e33299. doi: 10.1371/journal.pone.0033299 |
| Aubry*, C., Corr*, S.C., Wienerroither*, S., Goulard, C., Jones, R., Jamieson, A.M., Decker, T., O'Neill, L.A., Dussurget, O., and Cossart, P. (2012). *equal contribution Both TLR2 and TRIF Contribute to Interferon-beta Production during Listeria Infection. PLoS One 7: e33299. doi: 10.1371/journal.pone.0033299 |
| Petz, M., Them, N., Huber, H., Beug, H., and Mikulits, W. (2012). 1945-2011, SFB member of the 1st funding period; associated with coordination project La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition. Nucleic Acids Res 40: 290-302. doi: 10.1093/nar/gkr717 |
| Petz, M., Them, N.C., Huber, H., and Mikulits, W. (2012). PDGF enhances IRES-mediated translation of Laminin B1 by cytoplasmic accumulation of La during epithelial to mesenchymal transition. Nucleic Acids Res 40: 9738-9749. doi: 10.1093/nar/gks760 |
| Rampetsreiter, P. and Eferl, R. (2012). STAT1 and STAT3 Transcription Factors in Inflammation-Associated Colon Cancer. In Jak-Stat Signaling: From Basics to Disease. (Decker, T. and Müller, M. Eds.) Springer Wien Heidelberg New York Dordrecht London. pp. 289-304. [book chapter] doi: 10.1007/978-3-7091-0891-8_16 ISBN: 978-3-7091-0890-1 |
| Rohr-Udilova, N., Sieghart, W., Eferl, R., Stoiber, D., Bjorkhem-Bergman, L., L, C.E., Stolze, K., Hayden, H., Keppler, B., Sagmeister, S., Grasl-Kraupp, B., Schulte-Hermann, R., and Peck-Radosavljevic, M. (2012). Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma. Hepatology 55: 1112-1121. doi: 10.1002/hep.24808 |
| Allegra, M., Zaragkoulias, A., Vorgia, E., Ioannou, M., Litos, G., Beug, H., and Mavrothalassitis, G. (2012). 1945-2011, SFB member of the 1st funding period; associated with coordination project Semaphorin-7a reverses the ERF-induced inhibition of EMT in Ras-dependent mouse mammary epithelial cells. Mol Biol Cell 23: 3873-3881. doi: 10.1091/mbc.E12-04-0276 |
| Vogl, C., Shukla, P., and Ebersberger, I. (2012). Evolution of Jak and Stat Proteins. Jak-Stat Signaling: From Basics to Disease. Springer Wien Heidelberg New York Dordrecht London. pp. 99-114. [book chapter] doi: 10.1007/978-3-7091-0891-8_1 |
| Decker, T., and Müller, M. (2012) The Continuing Fascination with Jaks and Stats: An Introduction. Jak-Stat Signaling: From Basics to Disease. Springer Wien Heidelberg New York Dordrecht London. pp. 1-4. [book chapter] doi: 10.1007/978-3-7091-0891-8_1 |
| Decker, T., and Müller, M. (2012). Jak-Stat Signaling: From Basics to Disease. Jak-Stat Signaling: From Basics to Disease. Springer Wien Heidelberg New York Dordrecht London. 448 p. 45 illus. [book] doi: 10.1007/978-3-7091-0891-8_1 ISBN: 978-3-7091-0890-1 |
| Wallner*, B., Leitner*, N.R., Vielnascher, R.M., Kernbauer, E., Kolbe, T., Karaghiosoff, M., Rülicke, T., Decker, T., and Müller, M. (2012). *equal contribution Generation of mice with a conditional Stat1 null allele. Transgenic Res 21: 217-224. doi: 10.1007/s11248-011-9519-5 |
| Prchal-Murphy, M., Semper, C., Lassnig, C., Wallner, B., Gausterer, C., Teppner-Klymiuk, I., Kobolak, J., Müller, S., Kolbe, T., Karaghiosoff, M., Dinnyes, A., Rülicke, T., Leitner, N.R., Strobl, B., and Müller, M. (2012). TYK2 Kinase Activity Is Required for Functional Type I Interferon Responses In Vivo. PLoS One 7: e39141. doi: 10.1371/journal.pone.0039141 |
| Musteanu, M., Blaas, L., Zenz, R., Svinka, J., Hoffmann, T., Grabner, B., Schramek, D., Kantner, H.P., Müller, M., Kolbe, T., Rülicke, T., Moriggl, R., Kenner, L., Stoiber, D., Penninger, J., Popper, H., Casanova, E., and Eferl, R. (2012). A mouse model to identify cooperating signaling pathways in cancer. Nat Methods 9: 897-900. doi: 10.1038/nmeth.2130 |
| Mizutani*, T., Neugebauer*, N., Putz*, E.M., Moritz, N., Simma, O., Zebedin-Brandl, E., Gotthardt, D., Warsch, W., Eckelhart, E., Kantner, H.-P., Kalinke, U., Lienenklaus, S., Weiss, S., Strobl, B., Müller, M., Sexl, V., and Stoiber, D. (2012). *equal contribution Conditional IFNAR1 ablation reveals distinct requirements of Type I IFN signaling for NK cell maturation and tumor surveillance. Oncoimmunology 1: 1027-1037. doi: 10.4161/onci.21284 |
| Kovacic, B., Hoelbl, A., Litos, G., Alacakaptan, M., Schuster, C., Fischhuber, K.M., Kerenyi, M.A., Stengl, G., Moriggl, R., Sexl, V., and Beug, H. (2012). 1945-2011, SFB member of the 1st funding period; associated with coordination project Diverging fates of cells of origin in acute and chronic leukaemia. EMBO Mol Med 4: 283-297. doi: 10.1002/emmm.201100208 |
| Kernbauer, E., Maier, V., Stoiber, D., Strobl, B., Schneckenleithner, C., Sexl, V., Reichart, U., Kalinke, U., Reizis, B., Jamieson, A., Müller, M., and Decker, T. (2012). Conditional Stat1 ablation reveals the importance of interferon signaling for immunity to Listeria monocytogenes infection. PLoS Pathog 8: e1002763. doi: 10.1371/journal.ppat.1002763 |
| Friedbichler, K., Themanns, M., Mueller, K.M., Schlederer, M., Kornfeld, J.-W., Terracciano, L.M., Kozlov, A.V., Haindl, S., Kenner, L., Kolbe, T., Mueller, M., Snibson, K., Heim, M.H., and Moriggl, R. (2012). Growth hormone-induced STAT5 signaling causes gigantism, inflammation and premature death but protects mice from aggressive liver cancer. Hepatology 55: 941-952. doi: 10.1002/hep.24765 |
| Warsch, W., Grundschober, E., Berger, A., Gille, L., Cerny-Reiterer, S., Tigan, A.-S., Hoelbl-Kovacic, A., Valent, P., Moriggl, R., and Sexl, V. (2012). STAT5 triggers BCR-ABL1 mutation by mediating ROS production in chronic myeloid leukaemia. Oncotarget 3: 1669-1687. online ISSN: 1949-2553 |
| Putz*, E.M., Prchal-Murphy*, M., Simma, O.A., Forster, F., Koenig, X., Stockinger, H., Piekorz, R.P., Freissmuth, M., Müller, M., Sexl, V., and Zebedin-Brandl, E. (2012). *equal contribution PI3K? Is Essential for Tumor Clearance Mediated by Cytotoxic T Lymphocytes. PLoS One 7: e40852. doi: 10.1371/journal.pone.0040852 |
| Laimer, D., Dolznig, H., Kollmann, K., Vesely, P.W., Schlederer, M., Merkel, O., Schiefer, A.-I., Hassler, M.R., Heider, S., Amenitsch, L., Thallinger, C., Staber, P.B., Simonitsch-Klupp, I., Artaker, M., Lagger, S., Pileri, S., Piccaluga, P.P., Valent, P., Messana, K., Landra, I., Weichhart, T., Knapp, S., Shehata, M., Todaro, M., Sexl, V., Höfler, G., Piva, R., Medico, E., Riggeri, B.A., Cheng, M., Eferl, R., Egger, G., Penninger, J.M., Jaeger, U., Moriggl, R., Inghirami, G., and Kenner, L. (2012). PDGFR blockade is a rational and effective therapy for NPM-ALKdriven lymphomas. Nat Med 18: 1699-1704. doi: 10.1038/nm.2966 |
2011 Publications
| Kollmann, K., Heller, G., Ott, R.G., Scheicher, R., Zebedin-Brandl, E., Schneckenleithner, C., Simma, O., Warsch, W., Eckelhart, E., Hoelbl, A., Bilban, M., Zochbauer-Muller, S., Malumbres, M., and Sexl, V. (2011). C-JUN promotes BCR-ABL induced lymphoid leukemia by inhibiting methylation of the 5' region of Cdk6. Blood 117: 4065-4075. doi: dx.doi.org/10.1182/blood-2010-07-299644 |
| Hofmann, E., Reichart, U., Gausterer, C., Gülly, C., Meijer, D., Müller, M., and Strobl, B. (2010). Octamer-binding factor 6 (Oct-6/Pou3f1) is induced by interferon and contributes to dsRNA-mediated transcriptional responses. BMC Cell Biol 11: 61. doi: 10.1186/1471-2121-11-61 |
| Weichhart, T., Haidinger, M., Katholnig, K., Kopecky, C., Poglitsch, M., Lassnig, C., Rosner, M., Zlabinger, G.J., Hengstschläger, M., Müller, M., Hörl, W., and Säemann, M.D. (2011). Inhibition of mTOR blocks the anti-inflammatory effects of glucocorticoids in myeloid immune cells. Blood 117: 4273-4283. doi: http://dx.doi.org/10.1182/blood-2010-09-310888 |
| Todoric, J., Strobl, B., Jais, A., Boucheron, N., Bayer, M., Amman, S., Lindroos, J., Teperino, R., Prager, G., Bilban, M., Ellmeier, W., Krempler, F., Müller, M., Wagner, O., Patsch, W., Pospsilik, J.A., and Esterbauer, H. (2011). Cross-Talk Between Interferon-{gamma} and Hedgehog Signaling Regulates Adipogenesis. Diabetes 60: 1668-1676. doi: 10.2337/db10-1628 |
| Pichlmair, A., Lassnig, C., Eberle, C.-A., Górna, M.W., Baumann, C.L., Burkard, T.R., Bürckstümmer, T., Stefanovic, A., Krieger, S., Bennet, K.L., Rülicke, T., Weber, F., Colinge, J., Müller, M., and Superti-Furga, G. (2011). IFIT1 is an antiviral protein that recognizes 5-triphosphate RNA. Nat Immunol 12: 624-630. doi: 10.1038/ni.2048 |
| Kropp, K.A., Robertson, K.A., Sing, G., Rodriguez-Martin, S., Blanc, M., Lacaze, P., Noor Hassim, M.F.B., Khondoker, M.R., Busche, A., Dickinson, P., Forster, T., Strobl, B., Müller, M., Jonjic, S., Angulo, A., and Ghazal, P. (2011). Reversible inhibition of MCMV replication by IFN{gamma} in primary macrophages involves a primed type I IFN signaling sub-network for full establishment of an immediate-early antiviral-state. J Virol 85: 10286-10299. doi: 10.1128/JVI.00373-11 |
| Grunert, T., Leitner, N.R., Marchett-Deschmann, M., Miller, I., Wallner, B., Radwan, M., Vogl, C., Kolbe, T., Kratky, D., Gemeiner, M., Allmaier, G., Müller, M., and Strobl, B. (2011). A comparative proteome analysis links tyrosine kinase 2 (Tyk2) to the regulation of cellular glucose and lipid metabolism in response to poly(I:C). J Proteomics 74: 2866-2880. doi: 10.1016/j.jprot.2011.07.006 |
| Blanc, M., Hsieh, W., Robertson, K., Watterson, S., Shui, G., Lacaze, P., Khondoker, M., Dickinson, P., Sing, G., Rodriguez-Martin, S., Phelan, P., Forster, T., Strobl, B., Müller, M., Riemersma, R., Osborne, T., Wenk, M.R., Angulo, A., and Ghazal, P. (2011). Host Defense against Viral Infection Involves Interferon Mediated Down-Regulation of Sterol Biosynthesis. PLoS Biol 9: e1000598. doi: 10.1371/journal.pbio.1000598 |
| Ferbeyre, G., and Moriggl, R. (2011). The role of Stat5 transcription factors as tumor suppressors or oncogenes. Biochim Biophys Acta 1815: 104-114. [review] doi: 10.1016/j.bbcan.2010.10.004 |
| Ermakova, O., Piszczek, L., Luciani, L., Cavalli, F.M., Ferreira, T., Farley, D., Rizzo, S., Paolicelli, R.C., Al-Banchaabouchi, M., Nerlov, C., Moriggl, R., Luscombe, N.M., and Gross, C. (2011). Sensitized phenotypic screening identifies gene dosage sensitive region on chromosome 11 that predisposes to disease in mice. EMBO Mol Med 3: 50-66. doi: 10.1002/emmm.201000112 |
| van Zijl, F., Krupitza, G., and Mikulits, W. (2011). Initial steps of metastasis: Cell invasion and endothelial transmigration. Mutat Res 728: 23-34. [review] doi: 10.1016/j.mrrev.2011.05.002 |
| van Zijl*, F., Mall*, S., Machat, G., Pirker, C., Zeilinger, R., Weinhaeusel, A., Bilban, M., Berger, W., and Mikulits, W. (2011). *equal contribution A Human Model of Epithelial to Mesenchymal Transition to Monitor Drug Efficacy in Hepatocellular Carcinoma Progression. Mol Cancer Ther 10: 850-860. doi: 10.1158/1535-7163.MCT-10-0917 |
| Rampetsreiter, P., Casanova, E., and Eferl, R. (2011). Genetically modified mouse models of cancer invasion and metastasis. Drug Discov Today Dis Models 8: 67-74. [review] doi: 10.1016/j.ddmod.2011.05.003 |
| Mair, M., Blaas, L., Osterreicher, C.H., Casanova, E., and Eferl, R. (2011). JAK-STAT signaling in hepatic fibrosis. Front Biosci 17: 2794-2811. [review] doi: http://dx.doi.org/10.2741/3886 |
| Roetzer, A., Klopf, E., Gratz, N., Marcet-Houben, M., Hiller, E., Rupp, S., Gabaldon, T., Kovarik§, P., and Schuller, C. (2011). §SFB member of the 1st funding period Regulation of Candida glabrata oxidative stress resistance is adapted to host environment. FEBS Lett 585: 319-327. doi: 10.1016/j.febslet.2010.12.006 |
| Kratochvill, F., Machacek, C., Vogl, C., Ebner, F., Sedlyarov, V., Gruber, A.R., Hartweger, H., Vielnascher, R., Karaghiosoff, M., Rülicke, T., Müller, M., Hofacker, I., Lang, R., and Kovarik§, P. (2011). §SFB member of the 1st funding period Tristetraprolin-driven regulatory circuit controls quality and timing of mRNA decay in inflammation. Mol Sys Biol 7: 560. doi: 10.1038/msb.2011.93 |
| Gratz, N., Hartweger, H., Matt, U., Kratochwill, F., Janos, M., Sigel, S., Drobits, B., Li, X.-D., Knapp, S., and Kovarik§, P. (2011). §SFB member of the 1st funding period Type I Interferon Production Induced by Streptococcus pyogenes-Derived Nucleic Acids Is Required for Host Protection. PLoS Pathog 7: e1001345. doi: 10.1371/journal.ppat.1001345 |
| Strobl, B., Stoiber, D., Sexl, V., and Müller, M. (2011). Tyrosine kinase 2 (Tyk2) in cytokine signalling and host immunity. Front Biosci 17: 3224-3232. [review] doi: http://dx.doi.org/10.2741/3908 |
| Friedbichler, K., Hoelbl, A., Li, G., Bunting, K.D., Sexl, V., Gouilleux, F., and Moriggl, R. (2011). Serine phosphorylation of the Stat5a C-terminus is a driving force for transformation. Front Biosci 17: 3043-3056. [review] doi: http://dx.doi.org/10.2741/3897 |
Warsch, W., Kollmann, K., Eckelhart, E., Fajmann, S., Cerny-Reiterer, S., Holbl, A., Gleixner, K.V., Dworzak, M., Mayerhofer, M., Hoermann, G., Herrmann, H., Sillaber, C., Egger, G., Valent, P., Moriggl, R., and Sexl, V. (2011). High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia. Blood 117: 3409-3420. doi: http://dx.doi.org/10.1182/blood-2009-10-248211 |
| Schuster*, C., Berger*, A., Hoelzl, M.A., Putz, E.M., Frenzel, A., Simma, O., Moritz, N., Hoelbl, A., Kovacic, B., Freissmuth, M., Müller, M., Villunger, A., Mullauer, L., Schmatz, A.I., Streubel, B., Porpaczy, E., Jager, U., Stoiber, D., and Sexl, V. (2011). *equal contribution The cooperating mutation or "second hit" determines the immunological visibility towards MYC-induced murine lymphomas. Blood 118: 4635-4645. doi: http://dx.doi.org/10.1182/blood-2010-10-313098 |
| Schneller*, D., Machat*, G., Sousek*, A., Proell, V., van Zijl, F., Zulehner, G., Huber, H., Mair, M., Muellner, M.K., Nijman, S.M., Eferl, R., Moriggl, R., and Mikulits, W. (2011). *equal contribution p19(ARF) /p14(ARF) controls oncogenic functions of Stat3 in hepatocellular carcinoma. Hepatology 54: 164-172. doi: 10.1002/hep.24329 |
| Schneckenleithner, C., Bago-Horvath, Z., Dolznig, H., Neugebauer, N., Kollmann, K., Kolbe, T., Decker, T., Kerjaschki, D., Wagner, K.-U., Müller, M., Stoiber, D., and Sexl, V. (2011). Putting the brakes on mammary tumorigenesis: Loss of STAT1 predisposes to intraepithelial neoplasias. Oncotarget 2: 1043-1054. online ISSN: 1949-2553 |
| Mueller, K.M., Kornfeld, J.W., Friedbichler, K., Blaas, L., Egger, G., Esterbauer, H., Hasselblatt, P., Schlederer, M., Haindl, S., Wagner, K.U., Engblom, D., Haemmerle, G., Kratky, D., Sexl, V., Kenner, L., Kozlov, A.V., Terracciano, L., Zechner, R., Schuetz, G., Casanova, E., Pospisilik, J.A., Heim, M.H., and Moriggl, R. (2011). Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology 54: 1398-1409. doi: 10.1002/hep.24509 |
| Kornfeld, J.W., Isaacs, A., Vitart, V., Pospisilik, J.A., Meitinger, T., Gyllensten, U., Wilson, J.F., Rudan, I., Campbell, H., Penninger, J.M., Sexl, V., Moriggl, R., van Duijn, C., Pramstaller, P.P., and Hicks, A.A. (2011). Variants in STAT5B Associate with Serum TC and LDL-C Levels. J Clin Endocrinol Metab. 96: E1496-501. doi: dx.doi.org/10.1210/jc.2011-0322 |
| Eckelhart, E., Warsch, W., Zebedin, E., Simma, O., Stoiber, D., Kolbe, T., Rulicke, T., Mueller, M., Casanova, E., and Sexl, V. (2011). A novel Ncr1-Cre mouse reveals the essential role of STAT5 for NK cell survival and development. Blood 117: 1565-1573. doi: dx.doi.org/10.1182/blood-2010-06-291633 |
| Bourgeois, C., Majer, O., Frohner, I.E., Lesiak-Markowicz, I., Hildering, K.S., Glaser, W., Stockinger, S., Decker, T., Akira, S., Müller, M., and Kuchler, K. (2011). Conventional dendritic cells mount a type I interferone response against Candida spp requiring novel phagosomal TLR7 mediated IFN-? signaling. J Immunol 186, 3104-3112. doi: 10.4049/jimmunol.1002599 |
2010 Publications
| Beer-Hammer, S., Zebedin, E., von Holleben, M., Alferink, J., Reis, B., Dresing, P., Degrandi, D., Scheu, S., Hirsch, E., Sexl, V., Pfeffer, K., Nurnberg, B., and Piekorz, R.P. (2010). The catalytic PI3K isoforms F28110gamma and F28110delta contribute to B cell development and maintenance, transformation, and proliferation. J Leukoc Biol 87: 1083-1095. doi: 10.1189/jlb.0809585 |
| Vogl, C., Flatt, T., Fuhrmann, B., Hofmann, E., Wallner, B., Stiefvater, R., Kovarik, P., Strobl, B., and Müller, M. (2010). Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes. BMC Genomics 11: 199. doi: 10.1186/1471-2164-11-199 |
| Radwan*, M., Stiefvater*, R., Grunert, T., Sharif, O., Miller, I., Marchetti-Deschmann, M., Allmaier, G., Gemeiner, M., Knapp, S., Kovarik§, P., Müller, M., and Strobl, B. (2010). *equal contribution §SFB member of the 1st funding period Tyrosine kinase 2 controls IL-1beta production at the translational level. J Immunol 185: 3544-3553. doi: 10.4049/jimmunol.0904000 |
| Li, G., Miskimen, K.L., Wang, Z., Xie, X.Y., Tse, W., Gouilleux, F., Moriggl, R., and Bunting, K.D. (2010). Effective targeting of STAT5-mediated survival in myeloproliferative neoplasms using ABT-737 combined with rapamycin. Leukemia 24: 1397-1405. doi: 10.1038/leu.2010.131 |
| Creamer, B.A., Sakamoto, K., Schmidt, J.W., Triplett, A.A., Moriggl, R., and Wagner, K.U. (2010). Stat5 promotes survival of mammary epithelial cells through transcriptional activation of a distinct promoter in Akt1. Mol Cell Biol 30: 2957-2970. doi: 10.1128/MCB.00851-09 |
| Grusch, M., Petz, M., Metzner, T., Ozturk, D., Schneller, D., and Mikulits, W. (2010). The Crosstalk of RAS with the TGF-beta Family during Carcinoma Progression and its Implications for Targeted Cancer Therapy. Curr Cancer Drug Targets 10: 849-857. [review] doi: 10.2174/156800910793357943 |
| Madlener, S., Saiko, P., Vonach, C., Viola, K., Huttary, N., Stark, N., Popescu, R., Gridling, M., Vo, N.T., Herbacek, I., Davidovits, A., Giessrigl, B., Venkateswarlu, S., Geleff, S., Jager, W., Grusch, M., Kerjaschki, D., Mikulits, W., Golakoti, T., Fritzer-Szekeres, M., Szekeres, T., and Krupitza, G. (2010). Multifactorial anticancer effects of digalloyl-resveratrol encompass apoptosis, cell-cycle arrest, and inhibition of lymphendothelial gap formation in vitro. Br J Cancer 102: 1361-1370. doi: 10.1038/sj.bjc.6605656 |
| Li, G., Miskimen, K.L., Wang, Z., Xie, X.Y., Brenzovich, J., Ryan, J.J., Tse, W., Moriggl, R., and Bunting, K.D. (2010). STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease. Blood 115: 1416-1424. doi: 10.1182/blood-2009-07-234963 |
| van Zijl, F., and Mikulits, W. (2010). Hepatospheres: Three dimensional cell cultures resemble physiological conditions of the liver. World J Hepatol 2: 1-7. [review] doi: 10.4254/wjh.v2.i1.1 |
| Khan, M., Giessrigl, B., Vonach, C., Madlener, S., Prinz, S., Herbaceck, I., Holzl, C., Bauer, S., Viola, K., Mikulits, W., Quereshi, R.A., Knasmuller, S., Grusch, M., Kopp, B., and Krupitza, G. (2010). Berberine and a Berberis lycium extract inactivate Cdc25A and induce alpha-tubulin acetylation that correlate with HL-60 cell cycle inhibition and apoptosis. Mutat Res 683: 123-130. doi: 10.1016/j.mrfmmm.2009.11.001 |
| Roetzer, A., Gratz, N., Kovarik, P., and Schuller, C. (2010). Autophagy supports Candida glabrata survival during phagocytosis. Cell Microbiol 12: 199-216. doi: 10.1111/j.1462-5822.2009.01391.x |
| Maschler, S., Gebeshuber, C.A., Wiedemann, E.M., Alacakaptan, M., Schreiber, M., Custic, I., and Beug, H. (2010). 1945-2011, SFB member of the 1st funding period; associated with coordination project Annexin A1 attenuates EMT and metastatic potential in breast cancer. EMBO Mol Med 2: 401-414. doi: 10.1002/emmm.201000095 |
| Maier, H.J., Schmidt-Strassburger, U., Huber, M.A., Wiedemann, E.M., Beug, H., and Wirth, T. (2010). 1945-2011, SFB member of the 1st funding period; associated with coordination project NF-kappaB promotes epithelial-mesenchymal transition, migration and invasion of pancreatic carcinoma cells. Cancer Lett 295: 214-228. doi: 10.1016/j.canlet.2010.03.003 |
| Musteanu, M., Blaas, L., Mair, M., Schlederer, M., Bilban, M., Tauber, S., Esterbauer, H., Mueller, M., Casanova, E., Kenner, L., Poli, V., and Eferl, R. (2010). Stat3 is a negative regulator of intestinal tumor progression in Apc(Min) mice. Gastroenterology 138: 1003-1011. doi: 10.1053/j.gastro.2009.11.049 |
| Mair, M., Zollner, G., Schneller, D., Musteanu, M., Fickert, P., Gumhold, J., Schuster, C., Fuchsbichler, A., Bilban, M., Tauber, S., Esterbauer, H., Kenner, L., Poli, V., Blaas, L., Kornfeld, J.W., Casanova, E., Mikulits, W., Trauner, M., and Eferl, R. (2010). Signal transducer and activator of transcription 3 protects from liver injury and fibrosis in a mouse model of sclerosing cholangitis. Gastroenterology 138: 2499-2508. doi: 10.1053/j.gastro.2010.02.049 |
| Hoelbl*, A., Schuster*, C., Kovacic, B., Zhu, B., Wickre, M., Hoelzl, M.A., Fajmann, S., Grebien, F., Warsch, W., Stengl, G., Hennighausen, L., Poli, V., Beug, H., Moriggl, R., and Sexl, V. (2010). *equal contribution 1945-2011, SFB member of the 1st funding period; associated with coordination project Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia. EMBO Mol Med 2: 98-110. doi: 10.1002/emmm.201000062 |
| Friedbichler, K., Kerenyi, M.A., Kovacic, B., Li, G., Hoelbl, A., Yahiaoui, S., Sexl, V., Mullner§, E.W., Fajmann, S., Cerny-Reiterer, S., Valent, P., Beug, H., Gouilleux, F., Bunting, K.D., and Moriggl, R. (2010). §SFB member of the 1st funding period 1945-2011, SFB member of the 1st funding period; associated with coordination project Stat5a serine 725 and 779 phosphorylation is a prerequisite for hematopoietic transformation. Blood 116: 1548-1558. doi: 10.1182/blood-2009-12-258913 |
| Farlik, M., Reutterer, B., Schindler, C., Greten, F., Vogl, C., Müller, M., and Decker, T. (2010). Nonconventional Initiation Complex Assembly by STAT and NF-kappaB Transcription Factors Regulates Nitric Oxide Synthase Expression. Immunity 33: 25-34. doi: 10.1016/j.immuni.2010.07.001 |
| Blaas*, L., Kornfeld*, J.W., Schramek, D., Musteanu, M., Zollner, G., Gumhold, J., van Zijl, F., Schneller, D., Esterbauer, H., Egger, G., Mair, M., Kenner, L., Mikulits, W., Eferl, R., Moriggl, R., Penninger, J., Trauner, M., and Casanova, E. (2010). *equal contribution Disruption of the growth hormone--signal transducer and activator of transcription 5--insulinlike growth factor 1 axis severely aggravates liver fibrosis in a mouse model of cholestasis. Hepatology 51: 1319-1326. doi: 10.1002/hep.23469 |
| Zulehner, G., Mikula, M., Schneller, D., van Zijl, F., Huber, H., Sieghart, W., Grasl-Kraupp, B., Waldhor, T., Peck-Radosavljevic, M., Beug, H., and Mikulits, W. (2010). Nuclear beta-catenin induces an early liver progenitor phenotype in hepatocellular carcinoma and promotes tumor recurrence. Am J Pathol 176: 472-481. doi: 10.2353/ajpath.2010.090300 |
2009 Publications
| Schnidar, H., Eberl, M., Klingler, S., Mangelberger, D., Kasper, M., Hauser-Kronberger, C., Regl, G., Kroismayr, R., Moriggl, R., Sibilia, M. and Aberger, F. (2009). Epidermal growth factor receptor signaling synergizes with hedgehog/GLI in oncogenic transformation via activation of the MEK/ERK/JUN pathway. Cancer Res 69:1284-92. doi: 10.1158/0008-5472.CAN-08-2331 |
| Pflegerl, P., Vesely, P., Hantusch, B., Schlederer, M., Zenz, R., Janig, E., Steiner, G., Meixner, A., Petzelbauer, P., Wolf, P., Soleiman, A., Egger, G., Moriggl, R., Kishimoto, T., Wagner, E.F., and Kenner, L. (2009). Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proc Natl Acad Sci USA 106: 20423-20428. doi: 10.1073/pnas.0910371106 |
| Baumgartner, C., Sonneck, K., Mayerhofer, M., Gleixner, K., Fritz, R., Cerny-Reiterer, S., Kerenyi, M., Kornfeld, J.W., Sillaber, C., Moriggl, R. and Valent, P. (2009). Expression of activated STAT5 in neoplastic mast cells in systemic mastocytosis: subcellular distribution and role of the transforming oncoprotein KIT D816V. American J Pathol 75(6):2416-29. doi: 10.2353/ajpath.2009.080953 |
| van Zijl, F., Zulehner, G., Petz, M., Schneller, D., Kornauth, C., Hau, M., Machat, G., Grubinger, M., Huber, H. and Mikulits, W. (2009). Epithelial to mesenchymal transition in hepatocellular carcinoma. Fut Oncol 5(8): 1169-79. [review] doi: 10.2217/fon.09.91 |
| Macheiner, D., Gauglhofer, C., Rodgarkia-Dara, C., Grusch, M., Brachner, A., Bichler, C., Kandioler, D., Sutterluty, H., Mikulits, W., Schulte-Hermann, R., and Grasl-Kraupp, B. (2009). NORE1B is a putative tumor suppressor in hepatocarcinogenesis and may act via RASSF1A. Cancer Res 69: 235-242. doi: 10.1158/0008-5472.CAN-08-2144 |
| Lahsnig, C., Mikula, M., Petz, M., Zulehner, G., Schneller, D., van Zijl, F., Huber, H., Csiszar, A., Beug, H., and Mikulits, W. (2009). ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene 28: 638-650. doi: 10.1038/onc.2008.418 |
| Blaas, L., Musteanu, M., Eferl, R., Bauer, A. and Casanova, E. (2009). Bacterial artificial chromosomes improve recombinant protein production in mammalian cells. BMC Biotechnol 9:3. doi: 10.1186/1472-6750-9-3 |
| Stockinger, S. and Decker, T. (2009). STATs and infection. In JAK-STAT Pathways in Disease (Stephanou, A., Ed.). Landes Biosci, Austin, TX. pp. 43-57. [book chapter] ISBN-13: 978-1587063152 |
| Plumlee, C.R., Lee, C., Song, L., Prince, A., Beg, A., Decker, T., Shuman, H.A. and. Schindler, C. (2009). Interferons direct an effective innate response to Legionella pneumophila infection. J Biol Chem 284:30058-30066. doi: 10.1074/jbc.M109.018283 |
| Maldonado, R.A., Soriano, M.A., Perdomo, C., Sigrist, K., Irvine, D.J., Decker, T. and Glimcher, L.H. (2009). Control of T helper cell differentiation through cytokine receptor inclusion in the immunological synapse. J Exp Med 206(4):877-92. doi: 10.1084/jem.20082900 |
| Grundtner, P., Gruber, S., Murray, S.S., Vermeire, S., Rutgeerts, P., Decker, T., Lakatos, P.L. and Gasche, C. (2009). The IL10R1 S138G loss-of-function allele and ulcerative colitis. Genes Immun 10:84-92. doi: 10.1038/gene.2008.72 |
| Aly, S., Mages, J., Reiling, N., Kalinke, U., Decker, T., Lang, R. and Ehlers, S. (2009). Mycobacteria-induced granuloma necrosis depends on IRF-1. J Cell Mol Med 13:2069-2082. doi: 10.1111/j.1582-4934.2008.00470.x |
| Friedbichler, K., Kerenyi, M.A., Müllner, E.W. and Moriggl, R. (2009). Stat5 as hematopoietic gatekeeper and oncogene upon tyrosine kinase-induced transformation. In JAK-STAT Pathways in Disease (Stephanou, A., Ed.). Landes Biosci, Austin, TX. pp. 131-150. [book chapter] ISBN-13: 978-1587063152 |
| Ecker, A., Simma, O., Hoelbl, A., Kenner, L., Beug, H., Moriggl, R. and Sexl, V. (2009). The dark and the bright side of Stat3: proto-oncogene and tumor-suppressor. Front Biosci 14:2944-58. [review] doi: dx.doi.org/10.2741/3425 |
| van Zijl, F., Mair, M., Csiszar, A., Schneller, D., Zulehner, G., Huber, H., Eferl, R., Beug, H., Dolznig, H., and Mikulits, W. (2009). Hepatic tumor-stroma crosstalk guides epithelial to mesenchymal transition at the tumor edge. Oncogene 28: 4022-4033. doi: 10.1038/onc.2009.253 |
| Stockinger, S., Kastner, R., Kernbauer, E., Pilz, A., Westermayer, S., Reutterer, B., Soulat, D., Stengl, G., Vogl, C., Frenz, T., Waibler, Z., Taniguchi, T., Rulicke, T., Kalinke, U., Müller, M. and Decker, T. (2009). Characterization of the interferon-producing cell in mice infected with Listeria monocytogenes. PLoS Pathog 5, e1000355. doi: 10.1371/journal.ppat.1000355 |
| Simma, O., Zebedin, E., Neugebauer, N., Schellack, C., Pilz, A., Chang-Rodriguez, S., Lingnau, K., Weisz, E., Putz, E.M., Pickl, W.F., Felzmann, T., Müller, M., Decker, T., Sexl, V. and Stoiber, D. (2009). Identification of an indispensable role for tyrosine kinase 2 in CTL-mediated tumor surveillance. Cancer Res 69:203-11. doi: 10.1158/0008-5472.CAN-08-1705 |
| Schaljo, B., Kratochvill, F., Gratz, N., Sadzak, I., Sauer, I., Hammer, M., Vogl, C., Strobl, B., Müller, M., Blackshear, P.J., Poli, V., Lang, R., Murray, P.J. and Kovarik, P. (2009). Tristetraprolin is required for full anti-inflammatory response of murine macrophages to IL-10. J Immunol 183:1197-206. doi: 10.4049/jimmunol.0803883 |
| Prchal, M, Pilz, A., Simma, O., Lingnau, K., von Gabain, A., Strobl, B., Müller, M., and Decker, T. (2009). Type I interferons as mediators of immune adjuvants for T- and B cell- dependent acquired immunity. Vaccine 27 Suppl 6, G17-20. doi: 10.1016/j.vaccine.2009.10.016 |
| Pilz, A., Kratky, W., Stockinger, S., Simma, O., Kalinke, U., Lingnau, K., von Gabain, A., Stoiber, D., Sexl, V., Kolbe, T., Rulicke, T., Müller, M. and Decker, T. (2009). Dendritic cells require STAT-1 phosphorylated at its transactivating domain for the induction of peptide-specific CTL. J Immunol 183:2286-93. doi: 10.4049/jimmunol.0901383 |
| Lahsnig, C., Mikula, M., Petz, M., Zulehner, G., Schneller, D., van Zijl, F., Huber, H., Csiszar, A., Beug, H. and Mikulits, W. (2009). ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene 28:638-50. doi: 10.1038/onc.2008.418 |
2008 Publications
| Zebedin, E., Simma, O., Schuster, C., Putz, E.M., Fajmann, S., Warsch, W., Eckelhart, E., Stoiber, D., Weisz, E., Schmid, J.A., Pickl, W.F., Baumgartner, C., Valent, P., Piekorz, R.P., Freissmuth, M. and Sexl, V. (2008). Leukemic challenge unmasks a requirement for PI3Kdelta in NK cell-mediated tumor surveillance. Blood 112:4655-64. doi: 10.1182/blood-2008-02-139105 |
| Mayerhofer, M., Gleixner, K.V., Mayerhofer, J., Hoermann, G., Jaeger, E., Aichberger, K.J., Ott, R.G., Greish, K., Nakamura, H., Derdak, S., Samorapoompichit, P., Pickl, W.F., Sexl, V., Esterbauer, H., Schwarzinger, I., Sillaber, C., Maeda, H. and Valent, P. (2008). Targeting of heat shock protein 32 (Hsp 32)/heme oxygenase-1 (HO-1) in leukemic cells in chronic myleoid leukemia. A novel approach to overcome resistance against imatinib. Blood 111:2200-14. doi: http://dx.doi.org/10.1182/blood-2006-11-055723 |
| Weichhart, T., Costantino, G., Poglitsch, M., Rosner, M., Zeyda, M., Stuhlmeier, K.M., Kolbe, T., Stulnig, T.M., Horl, W.H., Hengstschlager, M., Müller, M. and Saemann, M.D. (2008). The TSC-mTOR signaling pathway regulates the innate inflammatory response. Immunity 29:565-77. doi: http://dx.doi.org/10.1016/j.immuni.2008.08.012 |
| Schneider, A., Reichart, U., Gerner, W., Kolbe, T., Saalmüller, A. and Müller, M. (2008). Selective contribution of Tyk2 to cell activation by lipopolysaccharide. FEBS Lett 582:3681-6. doi: 10.1016/j.febslet.2008.09.053 |
| Radwan, M., Miller, I., Grunert, T., Marchetti-Deschmann, M., Vogl, C., O'Donoghue, N., Dunn, M. J., Kolbe, T., Allmaier, G., Gemeiner, M., Müller, M. and Strobl§, B. (2008). §SFB member of the 2nd and 3rd funding period The impact of tyrosine kinase 2 (Tyk2) on the proteome of murine macrophages and their response to lipopolysaccharide (LPS). Proteomics 8:3469-85. doi: 10.1002/pmic.200800260 |
| Grunert, T., Marchetti-Deschmann, M., Miller, I., Müller, M. and Allmaier, G. (2008). Comparing the applicability of CGE-on-the-chip and SDS-PAGE for fast pre-screening of mouse serum samples prior to proteomics analysis. Electrophoresis 29:4332-40. doi: 10.1002/elps.200800035 |
| Costantino, G., Egerbacher, M., Kolbe, T., Karaghiosoff, M., Strobl§, B., Vogl, C., Helmreich, M. and Müller, M. (2008). §SFB member of the 2nd and 3rd funding period Tyk2 and signal transducer and activator of transcription 1 contribute to intestinal I/R injury. Shock 29:238-44. doi: 10.1097/shk.0b013e3180cab252 |
| Tsyrulnyk, A. and Moriggl, R. (2008). A detailed protocol for bacterial artificial chromosome recombineering to study essential genes in stem cells. Hematopoietic Stem Cell Protocols. Methods in Molecular BiologyTM, Humana Press. 430:269-293. [book chapter] doi: 10.1007/978-1-59745-182-6_19 Online ISBN: 978-1-59745-182-6 |
| Harir, N., Boudot, C., Friedbichler, K., Sonneck, K., Kondo, R., Martin-Lanneree, S., Kenner, L., Kerenyi, M., Yahiaoui, S., Gouilleux-Gruart, V., Gondry, J., Benit, L., Dusanter-Fourt, I., Lassoued, K., Valent, P., Moriggl*, R. and Gouilleux* F. (2008). *equal contribution and equal correspondence Oncogenic Kit controls neoplastic mast cell growth through a Stat5/PI3-kinase signaling cascade. Blood 112:2463-73. doi: 10.1182/blood-2007-09-115477 |
| Gratz, N., Siller, M., Schaljo, B., Pirzada, Z.A., Gattermeier, I., Vojtek, I., Kirschning, C.J., Wagner, H., Akira, S., Charpentier, E. and Kovarik, P. (2008). Group A streptococcus activates type I interferon Production and MyD88-dependent signaling without involvement of TLR2, TLR4, and TLR9. J Biol Chem 283:19879-87. doi: 10.1074/jbc.M802848200 |
| Sadzak, I., Schiff, M., Gattermeier, I., Glinitzer, R., Sauer, I., Saalmuller, A., Yang, E., Schaljo, B. and Kovarik, P. (2008). Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci USA 105:8944-9. (selected by the Faculty 1000 Biology) doi: 10.1073/pnas.0801794105 |
| Zenz, R., Eferl, R., Scheinecker, C., Redlich, K., Smolen, J., Schonthaler, H.B., Kenner, L., Tschachler, E. and Wagner, E.F. (2008). Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin disease. Arthritis Res Ther 10:201. doi: 10.1186/ar2338 |
| Eferl, R., Hasselblatt, P., Rath, M., Popper, H., Zenz, R., Komnenovic, V., Idarraga, M.H., Kenner, L. and Wagner, E.F. (2008). Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. Proc Natl Acad Sci USA 105:10525-30. doi: 10.1073/pnas.0801414105 |
| Stockinger, S. and Decker, T. (2008). New functions of type I interferons revealed by infection studies with Listeria monocytogenes. Immunobiol 213:889-97. [review] doi: 10.1016/j.imbio.2008.07.020 |
| von Gabain, A., Nagy, E. and Decker, T. (2008). Novel paradigms in vaccine development: from small pox eradication to therapeutic vaccines. Biol Chem 389:455-6. [commentary] doi: 10.1515/BC.2008.067 |
| Zwaferink, H., Stockinger, S., Reipert, S. and Decker, T. (2008). Stimulation of inducible nitric oxide synthase expression by interferon beta increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect Immun 76:1649-56. doi: 10.1128/IAI.01251-07 |
| Zwaferink, H., Stockinger, S., Hazemi, P., Lemmens-Gruber, R. and Decker, T. (2008). IFN? increases Listeriolysin O-induced membrane permeabilisation and death of macrophages. J Immunol 180:4116-23. doi: 10.4049/jimmunol.180.6.4116 |
| Soulat, D., Bürckstümmer, T., Westermayer, S., Goncalves, A., Bauch, A., Preradovic, A., Hantschel, O., Bennett, K.L., Decker*, T. and Superti-Furga*, G. (2008). *corresponding authors The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response. EMBO J 27:2135-46. doi: 10.1038/emboj.2008.126 |
| Huber, M., Steinwald, V., Guralnik, A., Brüstle, A., Kleemann, P., Rosenplänter, C., Decker, T. and Lohoff, M. (2008). IL-27 inhibits the development of regulatory T cells via STAT3. Int Immunol 20:223-34. doi: 10.1093/intimm/dxm139 |
| Gal, A., Sjöblom, T., Fedorova, L., Imreh, S., Beug, H., and Moustakas, A. (2008). Sustained TGFbeta exposure suppresses Smad and non-Smad signalling in mammary epithelial cells, leading to EMT and inhibition of growth arrest and apoptosis. Oncogene 27: 1218-1230. doi: 10.1038/sj.onc.1210741 |
| Kornfeld, J.W., Grebien, F., Kerenyi, M.A., Friedbichler, K., Kovacic, B., Zankl, B., Hoelbl, A., Nivarti, H., Beug, H., Sexl, V., Müller, M., Kenner, L., Müllner, E.W., Gouilleux, F. and Moriggl, R. (2008). The different functions of Stat5 and chromatin alteration through Stat5 proteins. Front Biosci 13:6237-54. [review] doi: dx.doi.org/10.2741/3151 |
| Schuster, C., Müller, M., Freissmuth, M., Sexl, V. and Stoiber, D. (2008). Commentary on H.Ide et al: Tyk2 expression and its signaling enhances invasiveness of prostate cancer cells. Biochem Biophys Res Commun 366:869-70. doi: 10.1016/j.bbrc.2007.12.017 |
| Reutterer, B., Stockinger, S., Pilz, A., Soulat, S., Kastner, R., Westermayer, S., Rülicke, T., Müller, M. and Decker, T. (2008). Type I IFN are host modulators of strain-specific Listeria monocytogenes virulence. Cell Microbiol 10:1116-29. doi: 10.1111/j.1462-5822.2007.01114.x |
| Mayerhofer, M., Gleixner, K.V., Hoelbl, A., Florian, S., Hoermann, G., Aichberger, K.J., Bilban, M., Esterbauer, H., Krauth, M.T., Sperr, W.R., Longley, J.B., Kralovic, R., Moriggl, R., Zappulla, J., Liblau, R.S., Schwarzinger, I., Sexl, V., Sillaber, C. and Valent, P. (2008). Unique effects of KIT D816V in BaF3 cells: induction of cluster formation, histamine synthesis, and early mast cell differentiation antigens. J Immunol 180:5466-76. doi: 10.4049/jimmunol.180.8.5466 |
| Kerenyi*, M.A., Grebien*, F., Gehart, H., Schifrer, M., Artaker, M., Kovacic, B., Beug, H., Moriggl, R. and Müllner, E.W. (2008). *equal contribution Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1. Blood 112:3878-88. doi: 10.1182/blood-2008-02-138339 |
| Grech, G., Blazquez-Domingo, M., Kolbus, A., Bakker, W.J., Müllner, E.W., Beug, H. and von Lindern, M. (2008). Igbp1 is part of a positive feedback loop in stem cell factor-dependent, selective mRNA translation initiation inhibiting erythroid differentiation. Blood 112:2750-60. doi: http://dx.doi.org/10.1182/blood-2008-01-133140 |
| Grebien, F., Kerenyi, M.A., Kovacic, B., Kolbe, T., Becker, V., Dolznig, H., Pfeffer, K., Klingmuller, U., Müller, M., Beug, H., Müllner*, E.W. and Moriggl*, R. (2008). *equal contribution and equal correspondence Stat5 activation enables erythropoiesis in the absence of EpoR and Jak2. Blood 111:4511-22. doi: http://dx.doi.org/10.1182/blood-2007-07-102848 |
2007 Publications
| Staber, P.B., Vesely, P., Haq, N., Ott, R.G., Funato, K., Bambach, I., Fuchs, C., Schauer, S., Linkesch, W., Hrzenjak, A., Dirks, W.G., Sexl, V., Bergler, H., Kadin, M.E., Sternberg, D.W., Kenner, L. and Hoefler, G. (2007). The oncoprotein NPM-ALK of anaplastic large cell lymphoma induces JUNB transcription via ERK1/2 abd JunB translation via mTOR signaling. Blood 110:3374-83. doi: http://dx.doi.org/10.1182/blood-2007-02-071258 |
| Ott, R.G., Simma, O., Kollmann, K., Weisz, E., Zebedin, E.M., Schorpp-Kistner, M., Heller, G., Zochbauer, S., Wagner, E.F., Freissmuth, M. and Sexl, V. (2007). Jun B is a gatekeeper for B-lymphoid leukemia. Oncogene 26:4863-71. doi: 10.1038/sj.onc.1210285 |
| Infante, A.A., Infante, D., Chan, M.C., How, P.C., Kutschera, W., Linhartova, I., Müllner, E.W., Wiche, G. and Propst, F. (2007). Ferritin associates with marginal band microtubules. Exp Cell Res 313:1602-14. doi: 10.1016/j.yexcr.2007.02.021 |
| del Prete, M.J., Vernal, R., Dolznig, H., Mullner, E.W. and Garcia-Sanz, J.A. (2007). Isolation of polysome-bound mRNA from solid tissues amenable for RT-PCR and profiling experiments. RNA 13:414-21. doi: 10.1261/rna.79407 |
| Painz, R., Walter, I., Kolbe, T., Rigler, D., Vogl, C., Steinborn, R., Rülicke, T., Helmreich, M., Karaghiosoff, M. and Müller, M. (2007). Organ-specific and differential requirement of TYK2 and IFNAR1 for LPS-induced iNOS expression in vivo. Immunobiol 212:863-75. doi: 10.1016/j.imbio.2007.09.017 |
| Gausterer, C., Müller, M., and Strobl§, B. (2007). §SFB member of the 2nd and 3rd funding period In vivo target validation: Methodology and Case Studies on the Janus kinase Tyk2. Anti-Inflammatory & Anti-Allergy Agents in Medical Chemistry 6, 29-45. doi: 10.2174/187152307779939697 |
| Yao, Z., Kanno, Y., Kerenyi, M., Stephens, G., Durant, L., Watford, W.T., Laurence, A., Robinson, G.W., Shevach, E.M., Moriggl, R., Hennighausen, L., Wu, C. and O'Shea, J.J. (2007). Nonredundant roles for Stat5a/b in directly regulating Foxp3. Blood 109:4368-75. doi: 10.1182/blood-2006-11-055756 |
| Tuckermann, J.P., Kleiman, A., Moriggl, R., Spanbroek, R., Neumann, A., Illing, A., Clausen, B.E., Stride, B., Forster, I., Habenicht, A.J., Reichardt, H.M., Tronche, F., Schmid, W. and Schutz, G. (2007). Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest 117:1381-90. doi: 10.1172/JCI28034 |
| Tsareva, S., Moriggl, R., Corvinus, F., Wiederanders, B., Schütz, A., Kovacic, B., Friedrich, K. (2007). STAT3 activation promotes invasive growth of colon carcinomas through matrix metalloproteinase induction. Neoplasia 9:279-91. doi: 10.1593/neo.06820 |
| Li, G., Wang, Z., Zhang, Y., Kang, Z., Haviernikova, E., Cui, Y., Hennighausen, L., Moriggl, R., Wang, D., Tse, W. and Bunting, K.D. (2007). STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output. Exp Hematol 35:1684-94. doi: 10.1016/j.exphem.2007.08.026 |
| Kovarik, P., Sauer, I. and Schaljo, B. (2007). Molecular mechanisms of the anti-inflammatory functions of interferons. Immunobiol 212: 895-901. [review] doi: 10.1016/j.imbio.2007.09.011 |
| Piskacek, S., Gregor, M., Nemethova, M., Grabner, M., Kovarik, P.* and Piskacek, M.* (2007). *corresponding authors Nine-amino-acid transactivation domain: establishment and prediction utilities. Genomics 89:756-68. doi: 10.1016/j.ygeno.2007.02.003 |
| Eferl, R., Zenz, R., Theussl, H.C. and Wagner, E.F. (2007). Simultaneous generation of fra-2 conditional and fra-2 knock-out mice. Genesis 45:447-51. doi: 10.1002/dvg.20311 |
| Bakiri, L., Takada, Y., Radolf, M., Eferl, R., Yaniv, M., Wagner, E.F. and Matsuo, K. (2007). Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation. Bone 40:867-75. doi: http://dx.doi.org/10.1016/j.bone.2006.11.005 |
| Blaas, L., Musteanu, M., Zenz, R., Eferl, R. and Casanova, E. (2007). PhiC31-mediated cassette exchange into a bacterial artificial chromosome. BioTechniques 43:659-64. doi: 10.2144/000112592 |
| Werts, C., Le Bourhis, L., Liu, J., Magalhaes, J.G., Fritz, J.H., Stockinger, S., Decker, T., Philpott, D., Ma, X. and Girardin, S.E. (2007). Nod1 and Nod2 induce CCL5/RANTES through the NF?B pathway. Eur J Immunol 37(9):2499-508. doi: 10.1002/eji.200737069 |
| Schroder, K., Spille, M., Pilz, A., Lattin, J., Bode, K.A., Irvine, K.M., Burrows, A.D., Ravasi, T., Weighardt, H., Stacey, K.J., Decker, T., Hume, D.A., Dalpke, A.H. and Sweet, M.J. (2007). Differential effects of CpG DNA on IFN? induction and STAT1 activation in murine macrophages versus dendritic cells: alternatively activated STAT1 negatively regulates toll-like receptor signalling in macrophages. J Immunol 179(6):3495-503. doi: 10.4049/jimmunol.179.6.3495 |
| Ramsauer, K., Farlik, M., Zupkovitz, G., Seiser, C., Kröger, A., Hauser, H.J. and Decker, T. (2007). Distinct modes of action applied by transcription factors STAT1 and IRF1 to initiate transcription of the IFN-?-inducible gbp2 gene. Proc Natl Acad Sci USA 104:2849-54. doi: 10.1073/pnas.0610944104 |
| Hui, L., Bakiri, L., Mairhorfer, A., Schweifer, N., Haslinger, C., Kenner, L., Komnenovic, V., Scheuch, H., Beug, H., and Wagner, E. F. (2007). p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Genet 39:741-9. doi: 10.1038/ng2033 |
| Mikula, M., Lahsnig, C., Fischer, A.N.M., Proell, V., Huber, H., Fuchs, E., Eger, A., Beug, H. and Mikulits, W. (2007). Epithelial plasticity of hepatocytes during liver tumor progression. (Bilko, N.M., et al., Eds.), Stem Cells and their Potential for Clinical Application, 123135, Springer. [book chapter] doi: 10.1007/978-1-4020-6469-2_9 ISBN 978-1-4020-6468-5 |
| Harir, N., Pecquet, C., Kerenyi, M., Sonneck, K., Kovacic, B., Nyga, R., Brevet, M., Dhennin, I., Gouilleux-Gruart, V., Beug, H., Valent, P., Lassoued, K., Moriggl, R. and Gouilleux, F. (2007). Constitutive activation of Stat5 promotes its cytoplasmic localization and association with PI3-kinase in myeloid leukemias. Blood 109:1678-86. doi: http://dx.doi.org/10.1182/blood-2006-01-029918 |
| Fischer, A.N., Fuchs, E., Mikula, M., Huber, H., Beug, H. and Mikulits, W. (2007). PDGF essentially links TGF-beta signaling to nuclear beta-catenin accumulation in hepatocellular carcinoma progression. Oncogene 26 (23):3395-405. doi: 10.1038/sj.onc.1210121 |
| Engblom, D., Kornfeld, J.W., Schwake, L., Tronche, F., Reimann, A., Beug, H., Hennighausen, L., Moriggl*, R. and Schütz*, G. (2007). *equal contribution and equal correspondence Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression. Genes Dev 21:1157-62. doi: 10.1101/gad.426007 |
| Aigner, K, Dampier, B, Descovich, L, Mikula, M, Sultan, A, Schreiber, M, Mikulits, W, Brabletz, T, Strand, D, Obrist, P, Sommergruber, W, Schweifer, N, Wernitznig, A, Beug, H, Foisner, R, and Eger, A (2007). The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 26: 3395-3405. doi: 10.1038/sj.onc.1210508 |
| Aigner, K, Descovich, L, Mikula, M, Sultan, A, Dampier, B, Bonne, S, van Roy, F, Mikulits, W, Schreiber, M, Brabletz, T, Sommergruber, W, Schweifer, N, Wernitznig, A, Beug, H, Foisner, R, and Eger, A (2007). The transcription factor ZEB1 (deltaEF1) represses Plakophilin 3 during human cancer progression. FEBS Lett 581: 1617-1624. doi: 10.1016/j.febslet.2007.03.026 |
2006 Publications
| Mikhael, M., Kim, S.F., Schranzhofer, M., Soe-Lin, S., Sheftel, A.D., Müllner, E.W. and Ponka, P. (2006). Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide. FEBS J 273:3828-36. doi: 10.1111/j.1742-4658.2006.05390.x |
| Leitner, N.R., Strobl§, B., Bokor, M., Painz, R., Kolbe, T., Rülicke, T., Müller, M. and Karaghiosoff, M. (2006). §SFB member of the 2nd and 3rd funding period A time- and dose-dependent STAT1 expression system. BMC Biotechnol 6:48. doi: 10.1186/1472-6750-6-48 |
| Mikula, M., Proell, V., Fischer, A.N.M. and Mikulits, W. (2006). Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-? dependent fashion. J Cell Physiol 209:560-7. doi: 10.1002/jcp.20772 |
| Stepniak*, E., Ricci*, R., Eferl*, R., Sumara, G., Sumara, I., Rath, M., Hui, L. and Wagner, E. F. (2006). *equal contribution c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev 20: 2306-14. doi: 10.1101/gad.390506 |
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