Two publications from the Institute of Pharmacology and Toxicology receive awards

Two publications from the Institute of Pharmacology and Toxicology at Vetmeduni Vienna were awarded prizes. The article “STAT5 is a key regulator in NK cells and acts as molecular switch from tumor surveillance to tumor promotion”, published in Cancer Discovery, received the research award from the City of Vienna Fund for innovative cancer research. The renowned Theodor Billroth Prize […]

The Janus Kinase JAK1 impacts on Natural Killer (NK) cell functions

The Janus kinase-signal transducers and activators of transcription (JAK-STAT) signaling pathway is critical in tuning immune responses and its dysregulation is tightly associated with cancer and immune disorders. Disruption of interleukin (IL)-15/STAT5 signaling pathway due to the loss of IL-15 receptor chains, JAK3 or STAT5 leads to immune deficiencies with natural killer (NK) cell abnormalities. […]

The best scientific posters at the Vetmeduni Vienna and the winners of the new VetIdeas Poster Challenge were announced as part of the ‘That’s Vet’ show. The Poster Award was decided in two categories by a jury of science journalists and also by the University Council. The winners of the VetIdeas Poster Challenge were determined in advance by a jury […]

STAT1’s shorter beta isoform recruits gene-specifically different components of the transcription machinery

STAT1 exists as two alternatively spliced isoforms, STAT1α and STAT1β; the latter lacks the C-terminal transactivation domain (TAD). Our previous study with gene-modified mice expressing only the STAT1β isoform (Stat1β/β) demonstrated that STAT1β is capable of inducing a subset of IFNγ-responsive genes but the reason for the gene-selectivity remained unclear. In this study we used […]

DDX3X – a determinant of gender differences in innate immunity?

RNA helicase DDX3X is important for many aspects of RNA metabolism and RNA translation. In addition, several publications have highlighted a role for DDX3X in immunity, as it contributes to the induction of type I IFNs. However, the in vivo relevance of DDX3X in cells of hematopoietic origin remains unexplored. Using mouse genetics, we demonstrate […]

Andrea Hölbl-Kovacic receives Heribert Konzett Prize

The Austrian Pharmacological Society has awarded the renowned Heribert Konzett Prize 2018 to Andrea Hölbl-Kovacic from the Institute of Pharmacology and Toxicology (in Veronika Sexl’s group). The award recognizes outstanding achievements in experimental and clinical pharmacology. This is the first time this prize is awarded to a member of the Vetmeduni Vienna. Andrea Hölbl-Kovacic convinced the selection with […]

Survival signalling mediated by Tyk2 is the Achilles’ heel of Anaplastic Large Cell Lymphomas

Anaplastic Large Cell Lymphomas (ALCL) is a rare type of lymphoma comprising approximately 16 percent of all T cell lymphomas. The molecular analysis of human tumour samples to find new, personalised therapeutic targets and their validation in tumour models has become a attractive approach in cancer research, which can advance clinical management of cancer patients. […]

The perfect balance in the blood

Hematopoietic stem cells (HSCs) sustain blood and immune cells in the body and are therefore crucial for our survival. HSCs are at rest, but as soon as blood needs to be formed – like after blood loss or chemotherapy – they are quickly activated to compensate for this loss. After completing their mission, they must return a […]

Natural killer (NK) cells are an innate weapon against cancer and virus-infected cells. The higher the NK cell activity, the higher its effect against a tumour. Researchers at Vetmeduni Vienna have now shown that the NK cell cytotoxic activity can be increased even further if the cdk8 gene is removed in these cells. This translates into an improved NK […]

From Receptors and Kinases towards Transcriptional Regulators: Cancer Genome Landscapes and their Therapeutic Targets

The invitation only meeting on May 6-9, 2018 boasts an outstanding scientific programme and will take place in a beautiful location and inspiring atmosphere. We have invited international experts to complement the scientific programme of the two SFBs, including: Jacqueline Bromberg, New York; Gerard Evan, Cambridge; Thomas Graf, Barcelona; Nancy Hynes, Basel; Shai Izraeli, Tel […]