Impact of JAK-STAT on chromatin of haematopoietic cells in malignant transformation
- Group Neubauer - Moriggl
Chromatin remodelling through oncogenic STAT5 in Peripheral T-Cell Leukaemia and Lymphoma
- Group Sexl
Oncogenes teaming up – activated STAT3 and STAT5 shaping chromatin in connection with CDK6
Constitutive JAK and/or STAT activation is found in most myeloproliferative neoplasms and in many other hematopoietic malignancies. It is frequently a biomarker of poor prognosis. The underlying molecular aberrations include activating mutations in or overexpression of signaling components (cytokine receptor, JAK, STAT), or rare JAK fusion proteins.
The research area investigates the oncogenic properties of aberrant levels of STATs 3, 5 and of mutants of TYK2 and STATs 3, 5 with respect to hematopoietic lineage-specific tumor initiation and disease progression.