JakStat Monarchies
6. May 2024 2024-09-10 11:01JakStat Monarchies
Understanding the JAK-STAT Pathway
One of the world's leading research groups, studying signal transmission by JAKs and STATs.
Our Mission
Our Research Areas
Infection, Immunity & Inflammation
The research area focuses on JAK-STAT function in haematopoietic and structural cells after immune-, inflammation- or stress-related stimuli. We investigate STATs 1 (incl. isoforms), 2, 3, 5 shaping the chromatin activities of bone marrow derived and tissue resident macrophages under homeostatic and differentiation conditions as well as upon infection with microbes. The impact of the JAK family member Tyrosine Kinase 2 (TYK2) on the gene control layers of naïve immune cells and the crosstalk between immune cells is the other focal point.
Hematopoietic Malignancies
Constitutive JAK and/or STAT activation is found in most myeloproliferative neoplasms and in many other hematopoietic malignancies. It is frequently a biomarker of poor prognosis. The underlying molecular aberrations include activating mutations in or overexpression of signaling components (cytokine receptor, JAK, STAT), or rare JAK fusion proteins.
Homeostatic Cell Type – Specific Regulation
Cellular and tissue homeostasis is the result of variables being regulated on chromatin level such that the internal environment remains stable and fairly constant even though the external environment varies. Cell type-specific homeostatic chromatin landscapes are maintained by tonic (constitutive) signals
provided by auto- and paracrine acting cytokines and growth factors as well as by cell-cell contacts. All SFB members contribute to the generation of a map of the JAK-STAT-shaped chromatin landscape of various hematopoietic and structural cell types under homeostatic in comparison to stressed or diseased conditions.