The JAK-STAT signaling pioneers James E Darnell, John J O‘Shea and George R Stark and former or current co-workers in their labs co-author a comprehensive review on the current knowledge on the cellular and systemic activities of JAKs and STATs and possibilities of their therapeutic targeting in disease settings (see https://doi.org/10.1016/j.cell.2022.09.023).
The Viennese JAK-STAT community congratulates this fascinating pathway to its 30ies anniversary!
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