A tailored mouse model for unravelling the development of NK cell malignancy

A consortium supported by the SFB and led by Dagmar Gotthard, Pharmacology and Toxicology Vetmeduni Vienna, developed a NK cell-specific mouse strain carrying a STAT5B gain-of-function mutation.  The genetically engineered mice develop a NK cell leukemia closely resembling the respective disease in human patients. The study will allow to develop prophylactic and treatment options for NK cell malignancies.

Published in Blood

Klara Klein, Sebastian Kollmann, Angela Hiesinger, Julia List, Jonatan Kendler, Thorsten Klampfl, Mehak Rhandawa, Jana Trifinopoulos, Barbara Maurer, Reinhard Grausenburger, Christof A. Betram, Richard Moriggl, Thomas Rülicke, Charles G. Mullighan, Agnieszka Witalisz-Siepracka, Wencke Walter, Gregor Hoermann, Veronika Sexl, Dagmar Gotthardt

A lineage-specific STAT5B^N642H mouse model to study NK-cell leukemia – https://doi.org/10.1182/blood.2023022655

(see Comment by Olli Difva, Wellcome Sanger Institute UK in Blood)

Unlocking a genetic model of NK-cell transformation – https://doi.org/10.1182/blood.2024024550