Infection & Immunity
- Lymphocyte Stat1 and immunity against Listeria monocytogenes
- Gene regulation by Stat1 isoforms in immunity against infection
- Kinase-inactive Tyk2 and IFN-II production-mediated immunity
Hematopoietic Malignancies & Tumor Immune Surveillance
- Oncogenic Jak2 and/or Stat5: cooperation with haplo-insufficient loss of tumour suppressors
- Tumour suppressing activity of Stat1 in leukemogenesis
- NK cell-mediated tumour surveillance: canonical and non-canonical Tyk2 or Stat1 activities
Molecular Mechanisms of Canonical &
Non-canonical Jak-Stat Action
- Stat1 isoform-specific transcriptional activity
- Stat1 / NFκB cooperativity and chromatin remodelling
- Tyk2 and Stat1: non-canonical effects on NK cell biology