Impact of JAK-STAT on chromatin of haematopoietic cells after immune-, inflammatory or stress-related challenges

  • Group Decker - Farlik

Parsing the pre-transcriptonal, transcriptional and posttranscriptional states of interferon-induced genes: chromatin architecture and its regulators

  • Group Knapp

L-MAC: Probing the STAT impact on homeostatic lung macrophage signatures

  • Group Strobl – Müller

TYK2 and STAT1 as multi-layered regulators in splenic immune and stromal cells

In the early 90ies of the last century experiments to the cellular response mechanisms to interferons led to the identification of the JAK-STAT pathway as a paradigm for signaling from the cell surface to chromatin. JAK-STAT controls the development and activity of hematopoietic cells. They provide inflammatory and immune stimuli and thereby regulate inflammation and immunity.

The research area focuses on STATs 1 (incl. isoforms), 2, 3, 5 shaping the chromatin activities of bone marrow derived and tissue resident macrophages under homeostatic and differentiation conditions as well as upon infection with microbes. The impact of the JAK family member Tyrosine Kinase 2 (TYK2) on the gene control layers of the cells in the tumor microenvironment and the crosstalk between immune cells in tumor surveillance is the other focal point.